Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity.

Animals Uncoupling Protein 1 / metabolism Mice Adipose Tissue, Brown / metabolism Cholesterol / metabolism Mitochondria / metabolism Lipidomics / methods Organ Specificity Mice, Inbred C57BL Adipose Tissue, White / metabolism Glycerophospholipids / metabolism Male Lipid Metabolism

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
Aug 2024
Historique:
received: 17 05 2024
revised: 24 05 2024
accepted: 27 05 2024
medline: 7 6 2024
pubmed: 7 6 2024
entrez: 6 6 2024
Statut: epublish

Résumé

Lipid composition is conserved within sub-cellular compartments to maintain cell function. Lipidomic analyses of liver, muscle, white and brown adipose tissue (BAT) mitochondria revealed substantial differences in their glycerophospholipid (GPL) and free cholesterol (FC) contents. The GPL to FC ratio was 50-fold higher in brown than white adipose tissue mitochondria. Their purity was verified by comparison of proteomes with ER and mitochondria-associated membranes. A lipid signature containing PC and FC, calculated from the lipidomic profiles, allowed differentiation of mitochondria from BAT of mice housed at different temperatures. Elevating FC in BAT mitochondria prevented uncoupling protein (UCP) 1 function, whereas increasing GPL boosted it. Similarly,

Identifiants

DOI: 10.26508/lsa.202402828 PMID: 38843936
pubmed: 38843936
pii: 7/8/e202402828
doi: 10.26508/lsa.202402828
pii:
doi:

Substances chimiques

Uncoupling Protein 1 0
Cholesterol 97C5T2UQ7J
Ucp1 protein, mouse 0
Glycerophospholipids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 Brunner et al.

Auteurs

Sarah Brunner (S)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
https://ror.org/02kkvpp62 ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany.

Marcus Höring (M)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

Gerhard Liebisch (G)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.

Sabine Schweizer (S)

https://ror.org/02kkvpp62 ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany.
ORCID: 0009-0000-7406-5294

Josef Scheiber (J)

BioVariance GmbH, Waldsassen, Germany.

Piero Giansanti (P)

https://ror.org/02kkvpp62 Bavarian Center for Biomolecular Mass Spectrometry at the University Hospital rechts der Isar, Technical University of Munich, Munich, Germany.
ORCID: 0000-0003-2857-0841

Maria Hidrobo (M)

https://ror.org/02kkvpp62 ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany.
ORCID: 0000-0002-6608-0088

Sven Hermeling (S)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
https://ror.org/02kkvpp62 ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany.
ORCID: 0009-0004-8323-3228

Josef Oeckl (J)

https://ror.org/02kkvpp62 Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.

Natalia Prudente de Mello (N)

Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD), Neuherberg, Germany.
Graduate School of Systemic Neurosciences (GSN), Ludwig-Maximilians University, Munich, Germany.

Fabiana Perocchi (F)

Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München and German National Diabetes Center (DZD), Neuherberg, Germany.
https://ror.org/02kkvpp62 Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany.
Munich Cluster of Systems Neurology, Munich, Germany.
ORCID: 0000-0002-1102-6500

Claudine Seeliger (C)

https://ror.org/02kkvpp62 ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany.

Akim Strohmeyer (A)

https://ror.org/02kkvpp62 Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
ORCID: 0000-0003-3650-9661

Martin Klingenspor (M)

https://ror.org/02kkvpp62 Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.
ORCID: 0000-0002-4502-6664

Johannes Plagge (J)

https://ror.org/02kkvpp62 ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany.

Bernhard Küster (B)

https://ror.org/02kkvpp62 Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
https://ror.org/02kkvpp62 Bavarian Biomolecular Mass Spectrometry Center, Technical University of Munich, Freising, Germany.

Ralph Burkhardt (R)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
ORCID: 0000-0003-1924-1202

Klaus-Peter Janssen (KP)

https://ror.org/02kkvpp62 Department of Surgery, School of Medicine, University Hospital rechts der Isar, Technical University of Munich, Munich Germany.

Josef Ecker (J)

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany josef.ecker@ukr.de.
https://ror.org/02kkvpp62 ZIEL Institute for Food & Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany.
ORCID: 0000-0003-4799-0788

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › Protéines de découplage mitochondrial › Protéine-1 de découplage › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux brun › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Lipidomique › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Phénomènes physiologiques › Spécificité d'organe › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux blanc › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Mitochondrial lipidomes are tissue specific -...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Mitochondrial lipidomes are tissue specific -...