Looping forward: exploring R-loop processing and therapeutic potential.
DNA damage
DNA repair
R‐loops
genome instability
transcription
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
06 Jun 2024
06 Jun 2024
Historique:
revised:
13
05
2024
received:
07
02
2024
accepted:
20
05
2024
medline:
7
6
2024
pubmed:
7
6
2024
entrez:
6
6
2024
Statut:
aheadofprint
Résumé
Recently, there has been increasing interest in the complex relationship between transcription and genome stability, with specific attention directed toward the physiological significance of molecular structures known as R-loops. These structures arise when an RNA strand invades into the DNA duplex, and their formation is involved in a wide range of regulatory functions affecting gene expression, DNA repair processes or cell homeostasis. The persistent presence of R-loops, if not effectively removed, contributes to genome instability, underscoring the significance of the factors responsible for their resolution and modification. In this review, we provide a comprehensive overview of how R-loop processing can drive either a beneficial or a harmful outcome. Additionally, we explore the potential for manipulating such structures to devise rationalized therapeutic strategies targeting the aberrant accumulation of R-loops.
Identifiants
pubmed: 38844597
doi: 10.1002/1873-3468.14947
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the European Union- Next Generation EU, Greece 2.0 National Recovery and Resilience plan, National Flagship Initiative "Health and Pharmaceuticals"
ID : TAEDR-0535850
Organisme : The Horizon 2020 Marie Curie ITN
ID : GA 812829
Organisme : The Horizon 2020 Marie Curie ITN
ID : GA 812830
Organisme : ELIDEK
ID : 15546
Organisme : Fondation Sante
Organisme : The "Research-Create-Innovate" actions (MIA-RTDI) "Panther"
ID : 00852
Organisme : Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.
ID : PAR00838
Organisme : Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A.
ID : PAR00863
Informations de copyright
© 2024 The Author(s). FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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