Multivariate Analysis of Solubility Parameters for Drug-Polymer Miscibility Assessment in Preparing Raloxifene Hydrochloride Amorphous Solid Dispersions.
Solubility
Polymers
/ chemistry
Excipients
/ chemistry
Raloxifene Hydrochloride
/ chemistry
Multivariate Analysis
X-Ray Diffraction
/ methods
Chemistry, Pharmaceutical
/ methods
Drug Carriers
/ chemistry
Drug Compounding
/ methods
Microscopy, Electron, Scanning
/ methods
Hydrogen Bonding
Crystallization
/ methods
amorphous solid dispersion
hansen solubility parameter
hierarchical clustering analysis
miscibility
principal component regression
Journal
AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111
Informations de publication
Date de publication:
06 Jun 2024
06 Jun 2024
Historique:
received:
26
03
2024
accepted:
21
05
2024
medline:
7
6
2024
pubmed:
7
6
2024
entrez:
6
6
2024
Statut:
epublish
Résumé
The success of obtaining solid dispersions for solubility improvement invariably depends on the miscibility of the drug and polymeric carriers. This study aimed to categorize and select polymeric carriers via the classical group contribution method using the multivariate analysis of the calculated solubility parameter of RX-HCl. The total, partial, and derivate parameters for RX-HCl were calculated. The data were compared with the results of excipients (N = 36), and a hierarchical clustering analysis was further performed. Solid dispersions of selected polymers in different drug loads were produced using solvent casting and characterized via X-ray diffraction, infrared spectroscopy and scanning electron microscopy. RX-HCl presented a Hansen solubility parameter (HSP) of 23.52 MPa
Identifiants
pubmed: 38844724
doi: 10.1208/s12249-024-02844-4
pii: 10.1208/s12249-024-02844-4
doi:
Substances chimiques
Polymers
0
Excipients
0
Raloxifene Hydrochloride
4F86W47BR6
Drug Carriers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
127Informations de copyright
© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.
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