A cost-effectiveness analysis of early detection and bundled treatment of postpartum hemorrhage alongside the E-MOTIVE trial.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
06 Jun 2024
06 Jun 2024
Historique:
received:
18
03
2024
accepted:
16
05
2024
medline:
7
6
2024
pubmed:
7
6
2024
entrez:
6
6
2024
Statut:
aheadofprint
Résumé
Timely detection and treatment of postpartum hemorrhage (PPH) are crucial to prevent complications or death. A calibrated blood-collection drape can help provide objective, accurate and early diagnosis of PPH, and a treatment bundle can address delays or inconsistencies in the use of effective interventions. Here we conducted an economic evaluation alongside the E-MOTIVE trial, an international, parallel cluster-randomized trial with a baseline control phase involving 210,132 women undergoing vaginal delivery across 78 secondary-level hospitals in Kenya, Nigeria, South Africa and Tanzania. We aimed to assess the cost-effectiveness of the E-MOTIVE intervention, which included a calibrated blood-collection drape for early detection of PPH and a bundle of first-response treatments (uterine massage, oxytocic drugs, tranexamic acid, intravenous fluids, examination and escalation), compared with usual care. We used multilevel modeling to estimate incremental cost-effectiveness ratios from the perspective of the public healthcare system for outcomes of cost per severe PPH (blood loss ≥1,000 ml) avoided and cost per disability-adjusted life-year averted. Our findings suggest that the use of a calibrated blood-collection drape for early detection of PPH and bundled first-response treatment is cost-effective and should be perceived by decision-makers as a worthwhile use of healthcare budgets. ClinicalTrials.gov identifier: NCT04341662 .
Identifiants
pubmed: 38844798
doi: 10.1038/s41591-024-03069-5
pii: 10.1038/s41591-024-03069-5
doi:
Banques de données
ClinicalTrials.gov
['NCT04341662']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001393
Pays : United States
Informations de copyright
© 2024. The Author(s).
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