Unraveling the relationship between serum parathyroid hormone levels and trabecular bone score: a cross-sectional study.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 06 2024
06 06 2024
Historique:
received:
26
10
2023
accepted:
04
06
2024
medline:
7
6
2024
pubmed:
7
6
2024
entrez:
6
6
2024
Statut:
epublish
Résumé
The TBS is a new method for clinicians to assess the bone quality. It is directly related to the mechanical strength of bone and helps predict fracture risk. The present analysis aimed to investigate the associations between serum PTH levels and TBS by analyzing data from the National Health and Nutrition Examination Survey (NHANES). A total of 3516 participants from the NHANES 2005-2006 were included in this cross-sectional study. The independent variable was serum PTH, and the outcome variable was TBS. The associations of serum PTH levels with TBS were examined using multivariable linear regression models. After adjusting for covariates, there was a negative association between serum PTH level and TBS (β = - 0.0034; 95% confidence interval, - 0.0050 to - 0.0017). However, in the subgroup analysis stratified by gender, race, and age, this association became negative only in Non-Hispanic White (β = - 0.0047, 95% CI: - 0.0071 to - 0.0048) and young people (age < 60) (β = - 0.0036, 95% CI: - 0.0057, - 0.0016), regardless of gender. In addition, the association of serum PTH with TBS was an U-shaped curve, with a point of inflection at 6.71 pmol/L. This study showed that serum PTH level was negatively associated with TBS. Maintaining PTH levels in a lower reasonable clinical range may be beneficial to bone health, especially for young non-Hispanic white.
Identifiants
pubmed: 38844829
doi: 10.1038/s41598-024-63979-9
pii: 10.1038/s41598-024-63979-9
doi:
Substances chimiques
Parathyroid Hormone
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13065Subventions
Organisme : Department of Health of Zhejiang Province
ID : 2022KY608
Organisme : Department of Health of Zhejiang Province
ID : 2022KY548, 2023KY494
Organisme : Department of Health of Zhejiang Province
ID : 2020KY408
Organisme : Hangzhou Medical and Health Technology Project
ID : B20200282
Organisme : Natural Science Foundation of Zhejiang Province
ID : LGD22H060004
Informations de copyright
© 2024. The Author(s).
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