Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors.
brain stem death
heart transplantation
left ventricular stroke work
speckle‐tracking echocardiography
Journal
European journal of clinical investigation
ISSN: 1365-2362
Titre abrégé: Eur J Clin Invest
Pays: England
ID NLM: 0245331
Informations de publication
Date de publication:
06 Jun 2024
06 Jun 2024
Historique:
revised:
21
05
2024
received:
27
01
2024
accepted:
23
05
2024
medline:
7
6
2024
pubmed:
7
6
2024
entrez:
7
6
2024
Statut:
aheadofprint
Résumé
The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload-independent left ventricular stroke work index (LVSWI) is alternatively recommended by the current guideline; however, pulmonary artery catheters are rarely inserted in organ donors in most jurisdictions. We propose a novel non-invasive echocardiographic parameter, Pressure-Strain Product (PSP), as a potential surrogate of catheter-based LVSWI. This study aimed to investigate if PSP could correlate with catheter-based LVSWI in an ovine model of brain stem death (BSD) donors. The association between PSP and myocardial mitochondrial function in the post-transplant hearts was also evaluated. Thirty-one female sheep (weight 47 ± 5 kg) were divided into two groups; BSD (n = 15), and sham neurologic injury (n = 16). Echocardiographic parameters including global circumferential strain (GCS) and global radial strain (GRS) and pulmonary artery catheter-based LVSWI were simultaneously measured at 8-timepoints during 24-h observation. PSP was calculated as a product of GCS or GRS, and mean arterial pressure for PSP In BSD donor hearts, PSP PSP
Sections du résumé
BACKGROUND
BACKGROUND
The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload-independent left ventricular stroke work index (LVSWI) is alternatively recommended by the current guideline; however, pulmonary artery catheters are rarely inserted in organ donors in most jurisdictions. We propose a novel non-invasive echocardiographic parameter, Pressure-Strain Product (PSP), as a potential surrogate of catheter-based LVSWI. This study aimed to investigate if PSP could correlate with catheter-based LVSWI in an ovine model of brain stem death (BSD) donors. The association between PSP and myocardial mitochondrial function in the post-transplant hearts was also evaluated.
METHODS
METHODS
Thirty-one female sheep (weight 47 ± 5 kg) were divided into two groups; BSD (n = 15), and sham neurologic injury (n = 16). Echocardiographic parameters including global circumferential strain (GCS) and global radial strain (GRS) and pulmonary artery catheter-based LVSWI were simultaneously measured at 8-timepoints during 24-h observation. PSP was calculated as a product of GCS or GRS, and mean arterial pressure for PSP
RESULTS
RESULTS
In BSD donor hearts, PSP
CONCLUSIONS
CONCLUSIONS
PSP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14259Subventions
Organisme : The National Health and Medical Research Council
ID : GNT1145761 - The Dead Heart Project
Organisme : Centre for Research Excellence for Advanced Cardiorespiratory Therapies Improving Organ Support (CRE ACTIONS)
Organisme : The Alfred Foundation
Organisme : The Metro North Hospital and Health Service
Organisme : The Donald and Joan Wilson Foundation
Organisme : The Prince Charles Hospital Foundation
ID : TM2017-02
Organisme : The Prince Charles Hospital Foundation
ID : RF-04
Organisme : University of Queensland
Organisme : Queensland Health
Organisme : Advance Queensland Industry Research Fellowship
Informations de copyright
© 2024 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.
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