Journal

Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951

Informations de publication

Date de publication:
05 Jun 2024
Historique:
received: 22 11 2023
accepted: 14 03 2024
medline: 7 6 2024
pubmed: 7 6 2024
entrez: 7 6 2024
Statut: epublish

Résumé

Insoluble amyloids rich in cross-β fibrils are observed in a number of neurodegenerative diseases. Depending on the clinicopathology, the amyloids can adopt distinct supramolecular assemblies, termed conformational strains. However, rapid methods to study amyloids in a conformationally specific manner are lacking. We introduce a novel computational method for

Identifiants

DOI: 10.1039/d3sc06245g PMID: 38846390 PMC: PMC11151861
pubmed: 38846390
doi: 10.1039/d3sc06245g
pii: d3sc06245g
pmc: PMC11151861
doi:

Types de publication

Journal Article

Langues

eng

Pagination

8414-8421

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Auteurs

Hailey M Wallace (HM)

Department of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco CA 94158 USA Bill.DeGrado@ucsf.edu Hailey.Wallace@ucsf.edu Hyunjun.Yang@ucsf.edu Sophia.Tan@ucsf.edu Henry.Pan@ucsf.edu Rose.Yang@ucsf.edu Junyixu@berkeley.edu Hyunil.Jo@ucsf.edu Carlo.Condello@ucsf.edu NicholasF_Polizzi@DFCI.harvard.edu.
ORCID: 0000-0002-9208-3063

Hyunjun Yang (H)

Department of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco CA 94158 USA Bill.DeGrado@ucsf.edu Hailey.Wallace@ucsf.edu Hyunjun.Yang@ucsf.edu Sophia.Tan@ucsf.edu Henry.Pan@ucsf.edu Rose.Yang@ucsf.edu Junyixu@berkeley.edu Hyunil.Jo@ucsf.edu Carlo.Condello@ucsf.edu NicholasF_Polizzi@DFCI.harvard.edu.
Institute for Neurodegenerative Diseases, University of California San Francisco CA 94143 USA.
ORCID: 0000-0003-2524-2201

Sophia Tan (S)

Department of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco CA 94158 USA Bill.DeGrado@ucsf.edu Hailey.Wallace@ucsf.edu Hyunjun.Yang@ucsf.edu Sophia.Tan@ucsf.edu Henry.Pan@ucsf.edu Rose.Yang@ucsf.edu Junyixu@berkeley.edu Hyunil.Jo@ucsf.edu Carlo.Condello@ucsf.edu NicholasF_Polizzi@DFCI.harvard.edu.
ORCID: 0000-0002-6181-7810

Henry S Pan (HS)

Department of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco CA 94158 USA Bill.DeGrado@ucsf.edu Hailey.Wallace@ucsf.edu Hyunjun.Yang@ucsf.edu Sophia.Tan@ucsf.edu Henry.Pan@ucsf.edu Rose.Yang@ucsf.edu Junyixu@berkeley.edu Hyunil.Jo@ucsf.edu Carlo.Condello@ucsf.edu NicholasF_Polizzi@DFCI.harvard.edu.
ORCID: 0000-0002-1323-037X

Rose Yang (R)

Department of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco CA 94158 USA Bill.DeGrado@ucsf.edu Hailey.Wallace@ucsf.edu Hyunjun.Yang@ucsf.edu Sophia.Tan@ucsf.edu Henry.Pan@ucsf.edu Rose.Yang@ucsf.edu Junyixu@berkeley.edu Hyunil.Jo@ucsf.edu Carlo.Condello@ucsf.edu NicholasF_Polizzi@DFCI.harvard.edu.
ORCID: 0000-0002-2534-0242

Junyi Xu (J)

Department of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco CA 94158 USA Bill.DeGrado@ucsf.edu Hailey.Wallace@ucsf.edu Hyunjun.Yang@ucsf.edu Sophia.Tan@ucsf.edu Henry.Pan@ucsf.edu Rose.Yang@ucsf.edu Junyixu@berkeley.edu Hyunil.Jo@ucsf.edu Carlo.Condello@ucsf.edu NicholasF_Polizzi@DFCI.harvard.edu.
ORCID: 0009-0006-0535-6892

Hyunil Jo (H)

Department of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco CA 94158 USA Bill.DeGrado@ucsf.edu Hailey.Wallace@ucsf.edu Hyunjun.Yang@ucsf.edu Sophia.Tan@ucsf.edu Henry.Pan@ucsf.edu Rose.Yang@ucsf.edu Junyixu@berkeley.edu Hyunil.Jo@ucsf.edu Carlo.Condello@ucsf.edu NicholasF_Polizzi@DFCI.harvard.edu.
ORCID: 0000-0002-4863-0779

Carlo Condello (C)

Institute for Neurodegenerative Diseases, University of California San Francisco CA 94143 USA.
Department of Neurology, University of California San Francisco CA 94143 USA.
ORCID: 0000-0002-8454-5360

Nicholas F Polizzi (NF)

Dana Farber Cancer Institute, Harvard Medical School Boston MA 02215 USA.
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School Boston MA 02215 USA.
ORCID: 0000-0002-1779-8907

William F DeGrado (WF)

Department of Pharmaceutical Chemistry, The Cardiovascular Research Institution, University of California San Francisco CA 94158 USA Bill.DeGrado@ucsf.edu Hailey.Wallace@ucsf.edu Hyunjun.Yang@ucsf.edu Sophia.Tan@ucsf.edu Henry.Pan@ucsf.edu Rose.Yang@ucsf.edu Junyixu@berkeley.edu Hyunil.Jo@ucsf.edu Carlo.Condello@ucsf.edu NicholasF_Polizzi@DFCI.harvard.edu.
Institute for Neurodegenerative Diseases, University of California San Francisco CA 94143 USA.
ORCID: 0000-0003-4745-263X

Classifications MeSH