An obituary: Dr. Helmut Cölfen 1965-2023.
Journal
European biophysics journal : EBJ
ISSN: 1432-1017
Titre abrégé: Eur Biophys J
Pays: Germany
ID NLM: 8409413
Informations de publication
Date de publication:
07 Jun 2024
07 Jun 2024
Historique:
received:
18
02
2024
accepted:
26
05
2024
revised:
14
04
2024
medline:
7
6
2024
pubmed:
7
6
2024
entrez:
7
6
2024
Statut:
aheadofprint
Résumé
Dr. Helmut Cölfen, an exceptional interdisciplinary scientist, mentor, colleague, and dear friend, passed away in November 2023 at the age of 58. His untimely departure is a profound loss for the fields of analytical ultracentrifugation, colloid, crystallization, and polymer research. This obituary pays tribute to Helmut, honoring his remarkable academic career and contributions to the study of nanochemistry, biophysics, and life sciences. Helmut was renowned for his pioneering research contributions in several key research areas: (1) Development of advanced analytical techniques: Helmut made major contributions to techniques such as analytical ultracentrifugation and field flow fractionation, which are widely utilized to characterize the structure of biomolecules and the growth of nanostructured crystalline materials; (2) Study of nucleation and crystallization processes: Helmut explored the early stages of crystallization which led to the discovery of pre-nucleation clusters and mesocrystal intermediates, in the presence of additives and templates; and (3) Investigation of structure and morphogenesis of mesocrystals, examining their molecular properties.
Identifiants
pubmed: 38847812
doi: 10.1007/s00249-024-01712-0
pii: 10.1007/s00249-024-01712-0
doi:
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. European Biophysical Societies' Association.
Références
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doi: 10.1002/chem.202002873
pubmed: 32569441
Chen Z, Schmid R, Wang X, Fu M, Han Z, Fan Q, Scheer E, Huang M, Nielaba P, Cölfen H (2023) Growth strategy for solution-phase growth of two-dimensional nanomaterials via a unified model. Nat Synth 2:670–677
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Cölfen H (2023) Analytical ultracentrifugation in colloid and polymer science: new possibilities and perspectives after 100 years. Colloid Polym Sci 301:821–849
doi: 10.1007/s00396-023-05130-0
Cölfen H, Antonietti M (2005) Mesocrystals: inorganic superstructures made by highly parallel crystallization and controlled alignment. Angew Chem Int Ed 44:5576–5591
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doi: 10.1002/9780470994603
Cölfen H, Harding SE (1997) MSTARA and MSTARI: interactive PC algorithms for simple, model independent evaluation of sedimentation equilibrium data. Eur Biophys J 25:333–346
doi: 10.1007/s002490050047
Cölfen H, Harding SE, Wilson EK, Scrutton NS, Winzor DJ (1997) Low temperature solution behaviour of Methylophilus methylotrophus electron transferring flavoprotein: a study by analytical ultracentrifugation. Eur Biophys J 25:411–416
doi: 10.1007/s002490050054
Cölfen H, Rosenberg R, Haffke D, Stemplinger S, Zemb T, Horinek D (2023) Two types of liquid phase separation induced by soft centrifugation in aqueous ethyl acetate using ethanol as cosolvent. Research 6:0026
doi: 10.34133/research.0026
pubmed: 37040494
pmcid: 10076002
De Yoreo JJ, Gilbert PUPA, Sommerdijk NAJM, Penn RL, Whitelam S, Joester D, Zhang H, Rimer JD, Navrotsky A, Banfield JF, Wallace AF, Michel FM, Meldrum FC, Cölfen H, Dove PM (2015) Crystallization by particle attachment in synthetic, biogenic, and geologic environments. Science 349:6760
doi: 10.1126/science.aaa6760
Gebauer D, Völkel A, Cölfen H (2008) Stable prenucleation calcium carbonate clusters. Science 322:1819–1822
doi: 10.1126/science.1164271
pubmed: 19095936
Gebauer D, Kellermeier M, Gale JD, Bergström L, Cölfen H (2014) Pre-nucleation clusters as solute precursors in crystallisation. Chem Soc Rev 43:2348–2371
doi: 10.1039/C3CS60451A
pubmed: 24457316
Gebauer D, Gale JD, Cölfen H (2022) Crystal nucleation and growth of inorganic ionic materials from aqueous solution: Selected recent developments, and implications. Small 18:2107735
doi: 10.1002/smll.202107735
Gorbet GE, Pearson JZ, Demeler AK, Colfen H, Demeler B (2015) Next-generation AUC: analysis of multiwavelength analytical ultracentrifugation data. Methods Enzymol 562:27–47
doi: 10.1016/bs.mie.2015.04.013
pubmed: 26412646
Harding SE, Cölfen H (1995) Inversion formulae for ellipsoid of revolution macromolecular shape functions. Anal Biochem 228:131–142
doi: 10.1006/abio.1995.1324
pubmed: 8572269
Hernández-Cifre JG, Rodríguez-Schmidt R, Almagro-Gómez CM, García de la Torre J (2022) Calculation of the friction, diffusion and sedimentation coefficients of nanoplatelets of arbitrary shape. Polymer 262:125467
doi: 10.1016/j.polymer.2022.125467
Jehannin M, Rao A, Cölfen H (2019) New horizons of nonclassical crystallization. J Am Chem Soc 141:10120–10136
doi: 10.1021/jacs.9b01883
pubmed: 31173682
Karabudak E, Cölfen H (2016) The multiwavelength UV/vis detector: new possibilities with an added spectral dimension. In: Uchiyama S, Arisaka F, Stafford WF, Laue T (eds) Analytical ultracentrifugation: instrumentation, software, and applications. Tokyo, Japan, Springer, pp 63–80
doi: 10.1007/978-4-431-55985-6_5
Karabudak E, Brookes E, Lesnyak V, Gaponik N, Eychmüller A, Walter J, Segets D, Peukert W, Wohlleben W, Demeler B, Cölfen H (2016) Simultaneous identification of spectral properties and sizes of multiple particles in solution with subnanometer resolution. Angew Chem Int Ed 55:11770–11774
doi: 10.1002/anie.201603844
Madeja B, Gebauer D, Marsiske MR, Ott A, Rückel M, Rosenberg R, Baken A, Stawski TM, Fernandez-Martinez A, Van Driessche AES, Cölfen H, Kellermeier M (2023) New insights into the nucleation of portlandite and the effects of polymeric additives. Cem Concr Res 173:107258
doi: 10.1016/j.cemconres.2023.107258
Mao L-B, Gao H-L, Yao H-B, Liu L, Cölfen H, Liu G, Chen S-M, Li S-K, Yan Y-X, Liu Y-Y, Yu S-H (2016) Synthetic nacre by predesigned matrix-directed mineralization. Science 354:107–110
doi: 10.1126/science.aaf8991
pubmed: 27540008
Meldrum FC, Cölfen H (2008) Controlling mineral morphologies and structures in biological and synthetic systems. Chem Rev 108:4332–4432
doi: 10.1021/cr8002856
pubmed: 19006397
Meldrum F, Cölfen H (2010) Crystallization and formation mechanisms of nanostructures. Nanoscale 2:2326–2327
doi: 10.1039/c0nr90029j
pubmed: 20949148
Pearson JZ, Krause F, Haffke D, Demeler B, Schilling K, Colfen H (2015) Next-generation AUC adds a spectral dimension: development of multiwavelength detectors for the analytical ultracentrifuge. Methods Enzymol 562:1–26
doi: 10.1016/bs.mie.2015.06.033
pubmed: 26412645
Peters E, Rosenberg R, Cölfen H, Boldt K (2022) Analysis of magic-size clusters in crude reaction mixtures using multiwavelength analytical ultracentrifugation. J Phys Chem C 126:2642–2655
doi: 10.1021/acs.jpcc.1c09327
Picker A, Nicoleau L, Burghard Z, Bill J, Zlotnikov I, Labbez C, Nonat A, Cölfen H (2017) Mesocrystalline calcium silicate hydrate: a bioinspired route toward elastic concrete materials. Sci Adv 3:e1701216
doi: 10.1126/sciadv.1701216
pubmed: 29209660
pmcid: 5710188
Rao A, Roncal-Herrero T, Schmid E, Drechsler M, Scheffner M, Gebauer D, Kröger R, Cölfen H (2019) On biomineralization: enzymes switch on mesocrystal assembly. ACS Cent Sci 5:357–364
doi: 10.1021/acscentsci.8b00853
pubmed: 30834324
pmcid: 6396387
Schneider CM, Cölfen H (2018) Analytical band centrifugation revisited. Eur Biophys J 47:799–807
doi: 10.1007/s00249-018-1315-1
pubmed: 29931388
Schneider CM, Cölfen H (2019) High-resolution analysis of small silver clusters by analytical ultracentrifugation. J Phys Chem Lett 10:6558–6564
doi: 10.1021/acs.jpclett.9b02755
pubmed: 31592670
Schneider CM, Haffke D, Cölfen H (2018) Band sedimentation experiment in analytical ultracentrifugation revisited. Anal Chem 90:10659–10663
doi: 10.1021/acs.analchem.8b02768
pubmed: 30160111
Seto J, Ma Y, Davis SA, Meldrum F, Gourrier A, Kim Y-Y, Schilde U, Sztucki M, Burghammer M, Maltsev S, Jäger C, Cölfen H (2012) Structure-property relationships of a biological mesocrystal in the adult sea urchin spine. Proc Natl Acad Sci 109:3699–3704
doi: 10.1073/pnas.1109243109
pubmed: 22343283
pmcid: 3309731
Song R-Q, Cölfen H (2011) Additive controlled crystallization. CrystEngComm 13:1249–1276
doi: 10.1039/c0ce00419g
Sturm EV, Cölfen H (2016) Mesocrystals: structural and morphogenetic aspects. Chem Soc Rev 45:5821–5833
doi: 10.1039/C6CS00208K
Sun S, Mao L-B, Lei Z, Yu S-H, Cölfen H (2016) Hydrogels from amorphous calcium carbonate and polyacrylic acid: bio-inspired materials for “mineral plastics.” Angew Chem Int Ed 55:11765–11769
doi: 10.1002/anie.201602849
Urban MJ, Holder IT, Schmid M, Fernandez Espin V, Garcia de la Torre J, Hartig JS, Cölfen H (2016) Shape analysis of DNA-Au hybrid particles by analytical ultracentrifugation. ACS Nano 10:7418–7427
doi: 10.1021/acsnano.6b01377
pubmed: 27459174
Völkle CM, Gebauer D, Cölfen H (2015) High-resolution insights into the early stages of silver nucleation and growth. Faraday Discuss 179:59–77
doi: 10.1039/C4FD00269E
pubmed: 25871922
Walter J, Löhr K, Karabudak E, Reis W, Mikhael J, Peukert W, Wohlleben W, Cölfen H (2014) Multidimensional analysis of nanoparticles with highly disperse properties using multiwavelength analytical ultracentrifugation. ACS Nano 8:8871–8886
doi: 10.1021/nn503205k
pubmed: 25130765
Wang T, Cölfen H, Antonietti M (2005) Nonclassical crystallization: mesocrystals and morphology change of CaCO3 crystals in the presence of a polyelectrolyte additive. J Am Chem Soc 127:3246–3247
doi: 10.1021/ja045331g
pubmed: 15755119
Zhang J, Pearson JZ, Gorbet GE, Colfen H, Germann MW, Brinton MA, Demeler B (2017) Spectral and hydrodynamic analysis of West Nile virus RNA-protein interactions by multiwavelength sedimentation velocity in the analytical ultracentrifuge. Anal Chem 89:862–870
doi: 10.1021/acs.analchem.6b03926
pubmed: 27977168