Plasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells.

Animals Phagocytosis / immunology Cell Membrane / metabolism Mice Mice, Knockout Myeloid Cells / immunology Mice, Inbred C57BL Neutrophils / immunology Macrophages / immunology

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
07 Jun 2024
Historique:
medline: 7 6 2024
pubmed: 7 6 2024
entrez: 7 6 2024
Statut: ppublish

Résumé

Professional phagocytes like neutrophils and macrophages tightly control what they consume, how much they consume, and when they move after cargo uptake. We show that plasma membrane abundance is a key arbiter of these cellular behaviors. Neutrophils and macrophages lacking the G protein subunit Gβ

Identifiants

DOI: 10.1126/sciimmunol.adl2388 PMID: 38848343
pubmed: 38848343
doi: 10.1126/sciimmunol.adl2388
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadl2388

Auteurs

Benjamin Y Winer (BY)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
ORCID: 0000-0001-7895-2544

Alexander H Settle (AH)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-5924-6994

Alexandrina M Yakimov (AM)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Carlos Jeronimo (C)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Tomi Lazarov (T)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-6312-0080

Murray Tipping (M)

Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-5262-2723

Michelle Saoi (M)

Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Anjelique Sawh (A)

New York Structural Biology Center, New York, NY, USA.
ORCID: 0000-0001-8649-7246

Anna-Liisa L Sepp (AL)

Department of Biomedical Engineering, Columbia University, New York, NY, USA.

Michael Galiano (M)

Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0003-4414-0358

Justin S A Perry (JSA)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0003-4063-6524

Yung Yu Wong (YY)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Frederic Geissmann (F)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-5029-2468

Justin Cross (J)

Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-6356-057X

Ting Zhou (T)

Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
SKI Stem Cell Research Facility, Center for Stem Cell Biology and Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY, USA.
ORCID: 0000-0003-1423-1507

Lance C Kam (LC)

Department of Biomedical Engineering, Columbia University, New York, NY, USA.
ORCID: 0000-0001-6812-4956

H Amalia Pasolli (HA)

Electron Microscopy Resource Center, Rockefeller University, New York, NY, USA.
ORCID: 0000-0003-3899-3530

Tobias Hohl (T)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-9097-5412

Jason G Cyster (JG)

Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA.
Howard Hughes Medical Institute, Chevy Chase, MD, USA.
ORCID: 0000-0002-4735-9745

Orion D Weiner (OD)

Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.
ORCID: 0000-0002-1778-6543

Morgan Huse (M)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-9941-7719

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Plasma membrane abundance dictates phagocytic...
questionsmedicales.fr › Phénomènes du système immunitaire › Phagocytose › Plasma membrane abundance dictates phagocytic...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Plasma membrane abundance dictates phagocytic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Plasma membrane abundance dictates phagocytic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Plasma membrane abundance dictates phagocytic...
questionsmedicales.fr › Cellules › Cellules myéloïdes › Plasma membrane abundance dictates phagocytic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Plasma membrane abundance dictates phagocytic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Plasma membrane abundance dictates phagocytic...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Plasma membrane abundance dictates phagocytic...