Chemoproteomic Identification of Spermidine-Binding Proteins and Antitumor-Immunity Activators.

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
07 Jun 2024
Historique:
medline: 7 6 2024
pubmed: 7 6 2024
entrez: 7 6 2024
Statut: aheadofprint

Résumé

Cancer immune therapies, particularly programmed cell death protein 1 (PD-1) blockade immunotherapy, falter in aged individuals due to compromised T-cell immunity. Spermidine, a biogenic polyamine that declines along with aging, shows promise in restoring antitumor immunity by enhancing mitochondrial fatty acid oxidation (FAO). Herein, we report a spermidine-based chemoproteomic probe (probe

Identifiants

DOI: 10.1021/jacs.3c14615 PMID: 38848460
pubmed: 38848460
doi: 10.1021/jacs.3c14615
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Vaibhav Pal Singh (VP)

Division of Biochemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Graduate School of Medicine, Kyoto University, Kyoto, Kyoto 606-8501, Japan.

Shuhei Hirose (S)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto 606-8501, Japan.

Misao Takemoto (M)

Division of Biochemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.

Asmaa M A S Farrag (AMAS)

Division of Biochemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Graduate School of Medicine, Kyoto University, Kyoto, Kyoto 606-8501, Japan.

Shin-Ichi Sato (SI)

Division of Biochemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
ORCID: 0000-0003-3085-419X

Tasuku Honjo (T)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto 606-8501, Japan.

Kenji Chamoto (K)

Division of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto 606-8501, Japan.
Department of Immuno-Oncology PDT, Graduate School of Medicine, Kyoto University, Kyoto, Kyoto 606-8501, Japan.

Motonari Uesugi (M)

Division of Biochemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan.
Graduate School of Medicine, Kyoto University, Kyoto, Kyoto 606-8501, Japan.
Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Kyoto, Kyoto 606-8372, Japan.
ORCID: 0000-0002-8515-445X

Classifications MeSH