DLco and echocardiographic parameters in identifying mild pulmonary hypertension in the EUSTAR cohort of systemic sclerosis patients.
TAPSE/sPAP
diffusing capacity of the lungs for carbon monoxide
pulmonary hypertension
screening
systemic sclerosis
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
05 Jun 2024
05 Jun 2024
Historique:
received:
31
01
2024
revised:
09
05
2024
accepted:
21
05
2024
medline:
8
6
2024
pubmed:
8
6
2024
entrez:
7
6
2024
Statut:
aheadofprint
Résumé
The 2022 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines define pulmonary hypertension (PH) as a resting mean pulmonary artery pressure (mPAP) > 20 mmHg at right heart catheterization (RHC). Previously, patients with a mPAP between 21 and 24 mmHg were classified in a "grey zone" of unclear clinical significance. What is the diagnostic performance of the main parameters used for PH screening in detecting systemic sclerosis (SSc) patients with mPAP 21-24 mmHg at RHC? SSc patients from the European Scleroderma Trials and Research (EUSTAR) database with available tricuspid annular plane systolic excursion (TAPSE), systolic PAP (sPAP) and mPAP data were included. Patients with mPAP 21-24 mmHg and patients with mPAP ≤ 20 mmHg were considered for the analysis. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were calculated. TAPSE/sPAP was lower in the group of SSc patients with mPAP 21-24 mmHg than in non-PH group [0.58 (0.46-0.72) mm/mmHg vs 0.69 (0.57-0.81) mm/mmHg, p < 0.01]. No difference was found in other parameters between the two groups. Diffusing capacity of the lungs for carbon monoxide (DL DL
Sections du résumé
BACKGROUND
BACKGROUND
The 2022 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines define pulmonary hypertension (PH) as a resting mean pulmonary artery pressure (mPAP) > 20 mmHg at right heart catheterization (RHC). Previously, patients with a mPAP between 21 and 24 mmHg were classified in a "grey zone" of unclear clinical significance.
RESEARCH QUESTION
OBJECTIVE
What is the diagnostic performance of the main parameters used for PH screening in detecting systemic sclerosis (SSc) patients with mPAP 21-24 mmHg at RHC?
STUDY DESIGN AND METHODS
METHODS
SSc patients from the European Scleroderma Trials and Research (EUSTAR) database with available tricuspid annular plane systolic excursion (TAPSE), systolic PAP (sPAP) and mPAP data were included. Patients with mPAP 21-24 mmHg and patients with mPAP ≤ 20 mmHg were considered for the analysis. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were calculated.
RESULTS
RESULTS
TAPSE/sPAP was lower in the group of SSc patients with mPAP 21-24 mmHg than in non-PH group [0.58 (0.46-0.72) mm/mmHg vs 0.69 (0.57-0.81) mm/mmHg, p < 0.01]. No difference was found in other parameters between the two groups. Diffusing capacity of the lungs for carbon monoxide (DL
INTERPRETATION
CONCLUSIONS
DL
Identifiants
pubmed: 38849072
pii: S0012-3692(24)00683-4
doi: 10.1016/j.chest.2024.05.010
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Oliver Distler
(O)
Mike Becker
(M)
Melissa De Decker
(M)
Danilo Alunni Fegatelli
(DA)
Elise Siegert
(E)
Ivan Castellví
(I)
Alberto Cauli
(A)
Kamal Solanki
(K)
Lorenzo Dagna
(L)
Mickaël Martin
(M)
Gianluca Moroncini
(G)
Hadi Poormoghim
(H)
Masataka Kuwana
(M)
Patricia E Carreira
(PE)
Paolo Airò
(P)
Julia Spierings
(J)
Yoshiya Tanaka
(Y)
Enrico Selvi
(E)
Tomas Soukup
(T)
Informations de copyright
Copyright © 2024. Published by Elsevier Inc.