Developmental origin of oligodendrocytes determines their function in the adult brain.


Journal

Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671

Informations de publication

Date de publication:
07 Jun 2024
Historique:
received: 13 12 2022
accepted: 25 04 2024
medline: 8 6 2024
pubmed: 8 6 2024
entrez: 7 6 2024
Statut: aheadofprint

Résumé

In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell populations and their progeny, oligodendrocytes, emerge from three distinct regions in a spatiotemporal gradient from ventral to dorsal. However, the functional importance of this oligodendrocyte developmental heterogeneity is unknown. Using a genetic strategy to ablate dorsally derived oligodendrocyte lineage cells (OLCs), we show here that the areas in which dorsally derived OLCs normally reside in the adult central nervous system become populated and myelinated by OLCs of ventral origin. These ectopic oligodendrocytes (eOLs) have a distinctive gene expression profile as well as subtle myelination abnormalities. The failure of eOLs to fully assume the role of the original dorsally derived cells results in locomotor and cognitive deficits in the adult animal. This study reveals the importance of developmental heterogeneity within the oligodendrocyte lineage and its importance for homeostatic brain function.

Identifiants

pubmed: 38849524
doi: 10.1038/s41593-024-01666-8
pii: 10.1038/s41593-024-01666-8
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Multiple Sclerosis Society (MS Society)
ID : n/a
Organisme : Multiple Sclerosis Society (MS Society)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Wellcome Trust (Wellcome)
ID : 100269-Z/12/Z; 108726-Z/15/Z
Organisme : Wellcome Trust (Wellcome)
ID : n/a
Organisme : Wellcome Trust (Wellcome)
ID : 011269/Z/12/Z
Organisme : RCUK | Medical Research Council (MRC)
ID : n/a
Organisme : RCUK | Medical Research Council (MRC)
ID : G0800575
Organisme : RCUK | Medical Research Council (MRC)
ID : G0800575
Organisme : National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs)
ID : NC-N001451-1
Organisme : National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs)
ID : NC-N001451-1
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2015-03558; 2019-01360
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 681893
Organisme : Hjärnfonden (Swedish Brain Foundation)
ID : F02017-0075
Organisme : Svenska Läkaresällskapet (Swedish Society of Medicine)
ID : JUB 2019
Organisme : DH | National Institute for Health Research (NIHR)
ID : AG072305

Informations de copyright

© 2024. The Author(s).

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Auteurs

Sarah Foerster (S)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Altos Labs, Cambridge Institute of Science, Cambridge, UK.

Elisa M Floriddia (EM)

Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden.

David van Bruggen (D)

Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden.

Petra Kukanja (P)

Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden.

Bastien Hervé (B)

Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden.

Shangli Cheng (S)

Ming Wai Lau Centre for Reparative Medicine, Stockholm and Hong Kong nodes, Karolinska Institutet, Stockholm, Sweden.

Eosu Kim (E)

Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Benjamin U Phillips (BU)

Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Christopher J Heath (CJ)

School of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK.

Richa B Tripathi (RB)

Wolfson Institute for Biomedical Research, University College London, London, UK.

Cody Call (C)

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Theresa Bartels (T)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Paediatrics, University of Cambridge, Cambridge, UK.

Katherine Ridley (K)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Paediatrics, University of Cambridge, Cambridge, UK.

Björn Neumann (B)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Altos Labs, Cambridge Institute of Science, Cambridge, UK.

Laura López-Cruz (L)

Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.

Abbe H Crawford (AH)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.

Cian J Lynch (CJ)

Altos Labs, Cambridge Institute of Science, Cambridge, UK.

Manuel Serrano (M)

Altos Labs, Cambridge Institute of Science, Cambridge, UK.

Lisa Saksida (L)

Department of Physiology and Pharmacology and Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

David H Rowitch (DH)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Paediatrics, University of Cambridge, Cambridge, UK.

Wiebke Möbius (W)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Klaus-Armin Nave (KA)

Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Matthew N Rasband (MN)

Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.

Dwight E Bergles (DE)

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Nicoletta Kessaris (N)

Wolfson Institute for Biomedical Research, University College London, London, UK.

William D Richardson (WD)

Wolfson Institute for Biomedical Research, University College London, London, UK.

Timothy J Bussey (TJ)

Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Department of Physiology and Pharmacology and Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, Canada.

Chao Zhao (C)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. czhao@altoslabs.com.
Altos Labs, Cambridge Institute of Science, Cambridge, UK. czhao@altoslabs.com.

Gonçalo Castelo-Branco (G)

Laboratory of Molecular Neurobiology, Karolinska Institutet, Stockholm, Sweden. goncalo.castelo-branco@ki.se.
Ming Wai Lau Centre for Reparative Medicine, Stockholm and Hong Kong nodes, Karolinska Institutet, Stockholm, Sweden. goncalo.castelo-branco@ki.se.

Robin J M Franklin (RJM)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. rfranklin@altoslabs.com.
Altos Labs, Cambridge Institute of Science, Cambridge, UK. rfranklin@altoslabs.com.

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