Developmental origin of oligodendrocytes determines their function in the adult brain.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
07 Jun 2024
07 Jun 2024
Historique:
received:
13
12
2022
accepted:
25
04
2024
medline:
8
6
2024
pubmed:
8
6
2024
entrez:
7
6
2024
Statut:
aheadofprint
Résumé
In the mouse embryonic forebrain, developmentally distinct oligodendrocyte progenitor cell populations and their progeny, oligodendrocytes, emerge from three distinct regions in a spatiotemporal gradient from ventral to dorsal. However, the functional importance of this oligodendrocyte developmental heterogeneity is unknown. Using a genetic strategy to ablate dorsally derived oligodendrocyte lineage cells (OLCs), we show here that the areas in which dorsally derived OLCs normally reside in the adult central nervous system become populated and myelinated by OLCs of ventral origin. These ectopic oligodendrocytes (eOLs) have a distinctive gene expression profile as well as subtle myelination abnormalities. The failure of eOLs to fully assume the role of the original dorsally derived cells results in locomotor and cognitive deficits in the adult animal. This study reveals the importance of developmental heterogeneity within the oligodendrocyte lineage and its importance for homeostatic brain function.
Identifiants
pubmed: 38849524
doi: 10.1038/s41593-024-01666-8
pii: 10.1038/s41593-024-01666-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Multiple Sclerosis Society (MS Society)
ID : n/a
Organisme : Multiple Sclerosis Society (MS Society)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Dr. Miriam & Sheldon G. Adelson Medical Research Foundation)
ID : n/a
Organisme : Wellcome Trust (Wellcome)
ID : 100269-Z/12/Z; 108726-Z/15/Z
Organisme : Wellcome Trust (Wellcome)
ID : n/a
Organisme : Wellcome Trust (Wellcome)
ID : 011269/Z/12/Z
Organisme : RCUK | Medical Research Council (MRC)
ID : n/a
Organisme : RCUK | Medical Research Council (MRC)
ID : G0800575
Organisme : RCUK | Medical Research Council (MRC)
ID : G0800575
Organisme : National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs)
ID : NC-N001451-1
Organisme : National Centre for the Replacement Refinement and Reduction of Animals in Research (NC3Rs)
ID : NC-N001451-1
Organisme : Vetenskapsrådet (Swedish Research Council)
ID : 2015-03558; 2019-01360
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 681893
Organisme : Hjärnfonden (Swedish Brain Foundation)
ID : F02017-0075
Organisme : Svenska Läkaresällskapet (Swedish Society of Medicine)
ID : JUB 2019
Organisme : DH | National Institute for Health Research (NIHR)
ID : AG072305
Informations de copyright
© 2024. The Author(s).
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