Connecting the dots: the role of fatigue in female infertility.
Fatigue
Female infertility
HPA axis
Inflammation
Stress
Journal
Reproductive biology and endocrinology : RB&E
ISSN: 1477-7827
Titre abrégé: Reprod Biol Endocrinol
Pays: England
ID NLM: 101153627
Informations de publication
Date de publication:
07 Jun 2024
07 Jun 2024
Historique:
received:
30
01
2024
accepted:
21
05
2024
medline:
8
6
2024
pubmed:
8
6
2024
entrez:
7
6
2024
Statut:
epublish
Résumé
Fatigue, an increasingly acknowledged symptom in various chronic diseases, has garnered heightened attention, during the medical era of bio-psycho-social model. Its persistence not only significantly compromises an individual's quality of life but also correlates with chronic organ damage. Surprisingly, the intricate relationship between fatigue and female reproductive health, specifically infertility, remains largely unexplored. Our exploration into the existing body of evidence establishes a compelling link between fatigue with uterine and ovarian diseases, as well as conditions associated with infertility, such as rheumatism. This observation suggests a potentially pivotal role of fatigue in influencing overall female fertility. Furthermore, we propose a hypothetical mechanism elucidating the impact of fatigue on infertility from multiple perspectives, postulating that neuroendocrine, neurotransmitter, inflammatory immune, and mitochondrial dysfunction resulting from fatigue and its co-factors may further contribute to endocrine disorders, menstrual irregularities, and sexual dysfunction, ultimately leading to infertility. In addition to providing this comprehensive theoretical framework, we summarize anti-fatigue strategies and accentuate current knowledge gaps. By doing so, our aim is to offer novel insights, stimulate further research, and advance our understanding of the crucial interplay between fatigue and female reproductive health.
Identifiants
pubmed: 38849828
doi: 10.1186/s12958-024-01235-5
pii: 10.1186/s12958-024-01235-5
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
66Subventions
Organisme : General Program of the National Natural Science Foundation of China
ID : 82371684, 82271672
Organisme : General Program of the National Natural Science Foundation of China
ID : 82371684, 82271672
Organisme : General Program of the National Natural Science Foundation of China
ID : 82371684, 82271672
Organisme : General Program of the National Natural Science Foundation of China
ID : 82371684, 82271672
Organisme : General Program of the National Natural Science Foundation of China
ID : 82371684, 82271672
Organisme : the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University
ID : JCRCWL-2022-001
Organisme : the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University
ID : JCRCWL-2022-001
Organisme : the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University
ID : JCRCWL-2022-001
Organisme : the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University
ID : JCRCWL-2022-001
Organisme : the Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University
ID : JCRCWL-2022-001
Organisme : the General Program of the Natural Science Foundation of Guangdong Province
ID : 2022A1515010650, 2023A1515011675
Organisme : the General Program of the Natural Science Foundation of Guangdong Province
ID : 2022A1515010650, 2023A1515011675
Organisme : the General Program of the Natural Science Foundation of Guangdong Province
ID : 2022A1515010650, 2023A1515011675
Organisme : the General Program of the Natural Science Foundation of Guangdong Province
ID : 2022A1515010650, 2023A1515011675
Organisme : the General Program of the Natural Science Foundation of Guangdong Province
ID : 2022A1515010650, 2023A1515011675
Informations de copyright
© 2024. The Author(s).
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