Stochastic Sensing of Chloride Anions Using an α-Hemolysin Pore with semiaza-Bambusuril Adapter.
Molecular Adapters, α-Hemolysin Nanopore, Bambusurils, Chloride Anions
Stochastic Sensing
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
08 Jun 2024
08 Jun 2024
Historique:
revised:
07
06
2024
received:
09
04
2024
accepted:
07
06
2024
medline:
8
6
2024
pubmed:
8
6
2024
entrez:
8
6
2024
Statut:
aheadofprint
Résumé
Pores containing molecular adapters provide internal selective binding sites, thereby allowing the stochastic sensing of analytes. Herein, we demonstrate that semiaza-bambusuril (BU) acts as a non-covalent molecular adapter when lodged within the lumen of the wild-type α-hemolysin (WT-αHL) protein pore. Because the bambusurils are recognized as anion receptors, the anion binding site within the adapter-nanopore complex allows the detection of chloride anions, thus converting a non-selective pore into an anion sensor.
Identifiants
pubmed: 38850111
doi: 10.1002/anie.202406719
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202406719Informations de copyright
© 2024 Wiley‐VCH GmbH.