Subclinical hypothyroidism predicts outcome in heart failure: insights from the T.O.S.CA. registry.

Heart failure Hormones Mortality Subclinical hypothyroidism

Journal

Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418

Informations de publication

Date de publication:
08 Jun 2024
Historique:
received: 04 04 2024
accepted: 28 05 2024
medline: 8 6 2024
pubmed: 8 6 2024
entrez: 8 6 2024
Statut: aheadofprint

Résumé

Subclinical hypothyroidism (SH), defined as increased serum thyroid-stimulating hormone (TSH) with normal free T4 (fT4) levels, is frequently observed in the general population. Prevalence ranges from 0.6% to 1.8% in the adult population, depending on age, sex, and iodine intake. Several studies reported a worse prognosis in patients with heart failure with reduced ejection fraction (HFrEF) and SH, but they considered heterogeneous populations suffering mainly from severe SH. Aim of this study was to evaluate if SH was independently associated with the occurrence of cardiovascular death considering 30 months of follow-up. 277 HFrEF patients enrolled in the prospective, multicenter, observational T.O.S.CA. (Terapia Ormonale Scompenso CArdiaco) registry, were included in this analysis. Patients were divided into two groups according to the presence of SH (serum TSH levels > 4.5 mIU/L with normal fT4 levels). Data regarding clinical status, echocardiography, and survival were analyzed. Twenty-three patients displayed SH (87% mild vs 13% severe), while 254 were euthyroid. No differences were found in terms of age, sex, HF etiology, and left ventricular ejection fraction. When compared with the euthyroid group, SH patients showed higher TSH levels (7.7 ± 4.1 vs 1.6 ± 0.9, p < 0.001), as expected, with comparable levels of fT4 (1.3 ± 0.3 vs 1.3 ± 0.3, p = NS). When corrected for established predictors of poor outcome in HF, the presence of SH resulted to be an independent predictor of cardiovascular mortality (HR: 2.96; 5-95% CI:1.13-7.74; p = 0.03). Since thyroid tests are widely available and inexpensive, they should be performed in HF patients to detect subclinical disorders, evaluate replacement therapy, and improve prognosis.

Identifiants

pubmed: 38850355
doi: 10.1007/s11739-024-03665-w
pii: 10.1007/s11739-024-03665-w
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Mariarosaria De Luca (M)

Department of Translational Medical Sciences, Federico II University, Naples, Italy.

Roberta D'Assante (R)

Department of Translational Medical Sciences, Federico II University, Naples, Italy.

Massimo Iacoviello (M)

Cardiology Unit, Department of Medical and Surgical Sciences, University of Foggia, 71122, Foggia, Italy.

Vincenzo Triggiani (V)

Interdisciplinary Department of Medicine-Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, University of Bari 'A Moro', Bari, Italy.

Giuseppe Rengo (G)

Department of Translational Medical Sciences, Federico II University, Naples, Italy.
Istituti Clinici Scientifici ICS Maugeri-S.P.A.-Istituti Di Ricovero E Cura a Carattere Scientifico (IRCCS) Istituto Scientifico Di Telese Terme, Telese, Italy.

Alfredo De Giorgi (A)

Clinical Medicine Unit, Department of Medicine, Azienda Ospedaliero-Universitaria S. Anna, Ferrara, Italy.

Giuseppe Limongelli (G)

Division of Cardiology, Monaldi Hospital, Azienda Ospedaliera Dei Colli, University of Campania Luigi Vanvitelli, Caserta, Italy.

Daniele Masarone (D)

Division of Cardiology, Monaldi Hospital, Azienda Ospedaliera Dei Colli, University of Campania Luigi Vanvitelli, Caserta, Italy.

Maurizio Volterrani (M)

Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy.

Antonio Mancini (A)

Operative Unit of Endocrinology, Catholic University of the Sacred Heart, Rome, Italy.

Andrea Passantino (A)

Scientific Clinical Institutes Maugeri, IRCCS, Bari, Italy.

Pasquale Perrone Filardi (P)

Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.

Angela Sciacqua (A)

Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Catanzaro, Italy.

Olga Vriz (O)

Heart Center Department, King Faisal Hospital & Research Center, Riyadh, Saudi Arabia.

Roberto Castello (R)

Division of General Medicine, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Michela Campo (M)

Department of Medical and Surgical Sciences, Unit of Endocrinology and Metabolic Diseases, University of Foggia, Foggia, Italy.

Giuseppe Lisco (G)

Interdisciplinary Department of Medicine-Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, University of Bari 'A Moro', Bari, Italy.

Pietro Amedeo Modesti (PA)

Department of Medical Sciences, School of Medicine, Pharmacy and Prevention, University of Ferrara, Ferrara, Italy.

Stefania Paolillo (S)

Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.

Toru Suzuki (T)

Department of Cardiovascular Sciences, University of Leicester, NIHR Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Andrea Salzano (A)

Cardiology Unit, A.O.R.N. Antonio Cardarelli, Naples, Italy.

Alberto Maria Marra (AM)

Department of Translational Medical Sciences, Federico II University, Naples, Italy.

Eduardo Bossone (E)

Department of Public Health, University "Federico II" of Naples, Naples, Italy.

Antonio Cittadini (A)

Department of Translational Medical Sciences, Federico II University, Naples, Italy. antonio.cittadini@unina.it.
Division of Internal Medicine & Metabolism & Rehabilitation, University Federico II, 80131, Naples, Italy. antonio.cittadini@unina.it.

Classifications MeSH