Naturalistic comparison of clomethiazole and Diazepam treatment in alcohol withdrawal: effects on oxidative stress, inflammatory cytokines and hepatic biomarkers.

Alcohol detoxification Alcohol withdrawal treatment Carbohydrate-deficient transferrin Clomethiazole Diazepam Dityrosine Ethyl glucuronide Inflammation Malondialdehyde Phosphatidylethanol Transaminases

Journal

European archives of psychiatry and clinical neuroscience
ISSN: 1433-8491
Titre abrégé: Eur Arch Psychiatry Clin Neurosci
Pays: Germany
ID NLM: 9103030

Informations de publication

Date de publication:
08 Jun 2024
Historique:
received: 28 03 2024
accepted: 27 05 2024
medline: 9 6 2024
pubmed: 9 6 2024
entrez: 8 6 2024
Statut: aheadofprint

Résumé

Ethanol is metabolized by alcohol dehydrogenase to acetaldehyde and induces cytochrome P450 2E1 (CYP2E1), which generates reactive oxygen species that cause inflammatory liver damage. Clomethiazole, a drug approved for alcohol withdrawal treatment (AWT) in some European countries, inhibits CYP2E1. We hypothesized that clomethiazole would lead to a faster reduction in oxidative stress, inflammatory cytokines, and liver enzymes compared to diazepam treatment. We analysed respective biomarkers in 50 patients undergoing AWT and 25 healthy individuals but found no statistical difference between the two medication groups over 3-5 days. Hence, our hypothesis was not confirmed during this observation period.

Identifiants

pubmed: 38851655
doi: 10.1007/s00406-024-01835-7
pii: 10.1007/s00406-024-01835-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Cheplapharm Arzeimittel (DE)
ID : CMZ study

Informations de copyright

© 2024. The Author(s).

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Auteurs

David Strischewski (D)

Department of Psychiatry, Otto-Von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Laboratory of Translational Psychiatry, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.
Department of Anaesthesiology and Intensive Care Medicine, Klinikum Chemnitz, Chemnitz, Germany.

Amira Kalmar (A)

Department of Psychiatry, Otto-Von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Laboratory of Translational Psychiatry, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.

Paul C Guest (PC)

Department of Psychiatry, Otto-Von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Laboratory of Translational Psychiatry, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.
Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.

Henrik Dobrowolny (H)

Department of Psychiatry, Otto-Von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Laboratory of Translational Psychiatry, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.

Gabriela Meyer-Lotz (G)

Department of Psychiatry, Otto-Von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Laboratory of Translational Psychiatry, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.

Conrad J Schiffner (CJ)

Department of Psychiatry, Otto-Von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Laboratory of Translational Psychiatry, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.
Department of Anesthesiology and Intensive Care Medicine, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.

Wolfgang Jordan (W)

Department of Psychiatry and Psychotherapy, Magdeburg Hospital GmbH, Magdeburg, Germany.
Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany.

Ulf J Müller (UJ)

Department of Psychiatry, Otto-Von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Laboratory of Translational Psychiatry, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.
Forensic Psychiatric State Hospital of Saxony-Anhalt, Stendal-Uchtspringe, Germany.

Katrin Borucki (K)

Institute of Clinical Chemistry and Pathobiochemistry, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.

Michael Böttcher (M)

MVZ Medizinische Labore Dessau Kassel GmbH, Dessau-Rosslau, Germany.

Borna Relja (B)

Department of Trauma, Hand, Plastic and Reconstructive Surgery, Translational and Experimental Trauma Research, University Hospital Ulm, University Ulm, Ulm, Germany.

Johann Steiner (J)

Department of Psychiatry, Otto-Von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany. johann.steiner@med.ovgu.de.
Laboratory of Translational Psychiatry, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany. johann.steiner@med.ovgu.de.
Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany. johann.steiner@med.ovgu.de.
Center for Health and Medical Prevention (CHaMP), Magdeburg, Germany. johann.steiner@med.ovgu.de.
German Center for Mental Health (DZPG), Partner Site Halle-Jena-Magdeburg, Magdeburg, Germany. johann.steiner@med.ovgu.de.

Classifications MeSH