Tongue coating metabolic profiles of intra-oral halitosis patients.
differentially abundant metabolite
halitosis
intra‐oral
liquid chromatography–mass spectrometry
tongue coating
untargeted metabolomics
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
09 Jun 2024
09 Jun 2024
Historique:
revised:
01
05
2024
received:
23
01
2024
accepted:
23
05
2024
medline:
9
6
2024
pubmed:
9
6
2024
entrez:
9
6
2024
Statut:
aheadofprint
Résumé
This study focused on the metabolic characteristics of tongue coating in patients with intra-oral halitosis (IOH) to investigate potential diagnostic biomarkers for IOH. Oral healthy participants were enrolled in this study. Halitosis was evaluated with an organoleptic assessment, a Halimeter®, and an OralChroma™. Tongue coating samples were collected from 18 halitosis patients and 18 healthy controls. Liquid chromatography-mass spectrometry was conducted to reveal the IOH-related metabolic variations in tongue coating. A total of 2214 metabolites were obtained. Most metabolites were shared between the two groups. A total of 274 upregulated metabolites, such as paramethasone acetate and indole-3-acetic acid, and 43 downregulated metabolites, including deoxyadenosine and valyl-arginine, were detected in the halitosis group. Functional analysis indicated that several metabolic pathways, including arginine biosynthesis, arginine and proline metabolism, histidine metabolism, and lysine degradation were significantly enriched in the IOH group. The least absolute shrinkage and selection operator logistic regression analysis revealed that paramethasone acetate, {1-[2-(4-carbamimidoyl-benzoylamino)-propionyl]-piperidin-4-yloxy}-acetic acid, indole-3-acetic acid, and valyl-arginine were remarkably associated with IOH. This study revealed the metabolites present in tongue coating and identified effective biomarkers, providing essential insights into the prediction, pathogenesis, and diagnosis of IOH.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Shanghai Municipal Health Commission
ID : 20234Y0103
Organisme : Shanghai Ninth People's Hospital Physicians in Clinical Research Training Program
ID : 2022hbyjxys-zy
Informations de copyright
© 2024 Wiley Periodicals LLC.
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