Psychological intervention improves quality of life in patients with early-stage cancer: a systematic review and meta-analysis of randomized clinical trials.

Humans Quality of Life Randomized Controlled Trials as Topic Neoplasms / psychology Psychosocial Intervention / methods Neoplasm Staging Female
Neoplasm Psychosocial intervention Quality of life Survival

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
09 Jun 2024
Historique:
received: 03 10 2023
accepted: 29 05 2024
medline: 10 6 2024
pubmed: 10 6 2024
entrez: 9 6 2024
Statut: epublish

Résumé

The effectiveness of psychological interventions (PI) for malignant diseases is controversial. We aimed to investigate the effect of PI on survival and quality of life (QoL) in patients with cancer. We performed a systematic search of MEDLINE, Cochrane, and Embase databases to identify randomized controlled trials comparing PI to standard care (PROSPERO registration number CRD42021282327). Outcomes were overall survival (OS), recurrence-free survival (RFS), and different domains of QoL. Subgroup analysis was performed based on the provider-, type-, environment-, duration of intervention; cancer stage, and type. Pooled hazard ratios (HR) and standardized mean difference (SMD) with 95% confidence intervals (CI) were calculated using a random-effects model. The OS and RFS did not differ significantly between the two groups (OS:HR = 0.97; CI 0.87-1.08; RFS:HR = 0.99; CI 0.84-1.16). However, there was significant improvement in the intervention group in all the analyzed domains of QoL; in the global (SMD = 0.65; CI 0.35-0.94), emotional (SMD = 0.64; CI 0.33-0.95), social (SMD = 0.32; CI 0.13-0.51) and physical (SMD = 0.33; CI 0.05-0.60) domains. The effect of PI on QoL was generally positive immediately, 12 and 24 weeks after intervention, but the effect decreased over time and was no longer found significant at 48 weeks. The results were better in the breast cancer group and early stages of cancer. PIs do not prolong survival, but they significantly improve the QoL of cancer patients. PI should be added as standard of care 3-4 times a year, at least for patients with early-stage cancer.

Identifiants

DOI: 10.1038/s41598-024-63431-y PMID: 38853187
pubmed: 38853187
doi: 10.1038/s41598-024-63431-y
pii: 10.1038/s41598-024-63431-y
doi:

Types de publication

Journal Article Systematic Review Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

13233

Informations de copyright

© 2024. The Author(s).

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Auteurs

Sára Anna Bognár (SA)

Institute of Pancreatic Diseases, Semmelweis University, 1083, Budapest, Hungary.
Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.

Brigitta Teutsch (B)

Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.
Institute for Translational Medicine, Medical School, University of Pécs, 7623, Pecs, Hungary.

Stefania Bunduc (S)

Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.

Dániel Sándor Veres (DS)

Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.
Department of Biophysics and Radiation Biology, Semmelweis University, 1085, Budapest, Hungary.

Bence Szabó (B)

Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.

Beatrix Fogarasi (B)

Institute of Pancreatic Diseases, Semmelweis University, 1083, Budapest, Hungary.

Olga Júlia Zahariev (OJ)

Institute of Pancreatic Diseases, Semmelweis University, 1083, Budapest, Hungary.
Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.

Nóra Vörhendi (N)

Institute for Translational Medicine, Medical School, University of Pécs, 7623, Pecs, Hungary.
Department of Internal Medicine, Siófok City Hospital and Outpatient Clinic, 8601, Siófok, Hungary.

Omer Almog (O)

Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.

Yael Hadani (Y)

Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.

Dorottya Gergő (D)

Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.
Department of Pharmacognosy, Semmelweis University, Üllői út 26, 1085, Budapest, Hungary.

Emese Mihály (E)

Department of Internal Medicine and Hematology, Medical School, Semmelweis University, 1088, Budapest, Hungary.

Bálint Erőss (B)

Institute of Pancreatic Diseases, Semmelweis University, 1083, Budapest, Hungary.
Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.
Institute for Translational Medicine, Medical School, University of Pécs, 7623, Pecs, Hungary.

Stefania Bunduc (S)

Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.
Center for Digestive Diseases and Liver Transplant, Fundeni Clinical Institute, 022328, Bucharest, Romania.

Katalin Márta (K)

Institute of Pancreatic Diseases, Semmelweis University, 1083, Budapest, Hungary.
Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary.
Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged, 6725, Szeged, Hungary.

Péter Hegyi (P)

Institute of Pancreatic Diseases, Semmelweis University, 1083, Budapest, Hungary. hegyi2009@gmail.com.
Centre for Translational Medicine, Semmelweis University, 1085, Budapest, Hungary. hegyi2009@gmail.com.
Institute for Translational Medicine, Medical School, University of Pécs, 7623, Pecs, Hungary. hegyi2009@gmail.com.
Translational Pancreatology Research Group, Interdisciplinary Centre of Excellence for Research Development and Innovation University of Szeged, 6725, Szeged, Hungary. hegyi2009@gmail.com.

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questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Psychological intervention improves quality of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Psychological intervention improves quality of...
questionsmedicales.fr › Tumeurs › Psychological intervention improves quality of...
questionsmedicales.fr › Disciplines et activités comportementales › Psychothérapie › Intervention psychosociale › Psychological intervention improves quality of...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Psychological intervention improves quality of...