Brain metabolism after therapeutic hypothermia for murine hypoxia-ischemia using hyperpolarized [1-
anaerobic metabolism
hyperpolarized [1‐13C] pyruvate MR spectroscopy
hypoxic‐ischemic encephalopathy
therapeutic hypothermia
Journal
NMR in biomedicine
ISSN: 1099-1492
Titre abrégé: NMR Biomed
Pays: England
ID NLM: 8915233
Informations de publication
Date de publication:
10 Jun 2024
10 Jun 2024
Historique:
revised:
16
04
2024
received:
22
11
2023
accepted:
12
05
2024
medline:
10
6
2024
pubmed:
10
6
2024
entrez:
10
6
2024
Statut:
aheadofprint
Résumé
Hypoxic-ischemic encephalopathy (HIE) is a common neurological syndrome in newborns with high mortality and morbidity. Therapeutic hypothermia (TH), which is standard of care for HIE, mitigates brain injury by suppressing anaerobic metabolism. However, more than 40% of HIE neonates have a poor outcome, even after TH. This study aims to provide metabolic biomarkers for predicting the outcomes of hypoxia-ischemia (HI) after TH using hyperpolarized [1-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e5196Subventions
Organisme : Research Council of Finland (decision No. 355256)
Organisme : Academy of Finland (decision Nos. 326494, 326495, and 345280)
Organisme : NIH R35
ID : 5R35NS097299
Organisme : Academy of Finland
ID : 326494
Organisme : Academy of Finland
ID : 326495
Organisme : Academy of Finland
ID : 345280
Organisme : NIH HHS
ID : 5P41EB013598
Pays : United States
Informations de copyright
© 2024 The Author(s). NMR in Biomedicine published by John Wiley & Sons Ltd.
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