Cysteinyl leukotriene-like metabolites are generated in retinal pigment epithelial cells through glutathionylation/reduction of an oxidatively truncated fragment of arachidonate.
Free radical-induced lipid oxidation
Hypoxia-inducible factor
Pseudo leukotrienes
Retinal Pigment Epithelial Cells
Journal
Results in chemistry
ISSN: 2211-7156
Titre abrégé: Results Chem
Pays: Netherlands
ID NLM: 101758472
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
10
6
2024
pubmed:
10
6
2024
entrez:
10
6
2024
Statut:
ppublish
Résumé
γ-Hydroxyalkenals, 4-hydroxynonenal (HNE) and phospholipid esters of 4-hydroxy-8-oxooctenoic acid (HOOA-PL), are produced from the alkyl and carboxyl termini of arachidonyl phospholipids by radical-induced oxidative cleavage. Metabolism of HNE by Michael addition of glutathione (GSH) followed by reduction of the aldehyde carbonyl produces a GSH derivative of 1,4-dihydroxynonane (DHN)-GSH. Analogous biochemistry was anticipated to produce a GSH derivative of 5,8-dihydroxyoctanoic acid (DHOA-GSH) that has structural and functional similarity to the cysteinyl leukotriene (LT)C
Identifiants
pubmed: 38855016
doi: 10.1016/j.rechem.2023.100995
pmc: PMC11160973
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.