Insights into the voltage-gated sodium channel, Na

Nav1.8 abdominal pain visceral voltage-gated sodium channel

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2024
Historique:
received: 12 03 2024
accepted: 29 04 2024
medline: 10 6 2024
pubmed: 10 6 2024
entrez: 10 6 2024
Statut: epublish

Résumé

Pain is a major issue in healthcare throughout the world. It remains one of the major clinical issues of our time because it is a common sequela of numerous conditions, has a tremendous impact on individual quality of life, and is one of the top drivers of cost in medicine, due to its influence on healthcare expenditures and lost productivity in those affected by it. Patients and healthcare providers remain desperate to find new, safer and more effective analgesics. Growing evidence indicates that the voltage-gated sodium channel Na

Identifiants

pubmed: 38855747
doi: 10.3389/fphar.2024.1398409
pii: 1398409
pmc: PMC11158627
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1398409

Informations de copyright

Copyright © 2024 Heinle, Dalessio, Janicki, Ouyang, Vrana, Ruiz-Velasco and Coates.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

J Westley Heinle (JW)

Division of Gastroenterology and Hepatology, Penn State College of Medicine, Hershey, PA, United States.

Shannon Dalessio (S)

Division of Gastroenterology and Hepatology, Penn State College of Medicine, Hershey, PA, United States.

Piotr Janicki (P)

Department of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, PA, United States.

Ann Ouyang (A)

Division of Gastroenterology and Hepatology, Penn State College of Medicine, Hershey, PA, United States.

Kent E Vrana (KE)

Department of Pharmacology, Penn State College of Medicine, Hershey, PA, United States.

Victor Ruiz-Velasco (V)

Department of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, PA, United States.

Matthew D Coates (MD)

Division of Gastroenterology and Hepatology, Penn State College of Medicine, Hershey, PA, United States.
Department of Pharmacology, Penn State College of Medicine, Hershey, PA, United States.

Classifications MeSH