Natural compound Alternol exerts a broad anti-cancer spectrum and a superior therapeutic safety index

Alternol is a natural compound isolated from the fermentation of a mutated fungus. We have demonstrated its potent anti-cancer effect We first tested its anti-cancer spectrum using the National Cancer Institute-60 (NCI-60) screening, a protein quantitation-based assay. CellTiter-Glo screening was utilized for ovarian cancer cell lines. Cell cycle distribution was analyzed using flow cytometry. Xenograft models in nude mice were used to assess anti-cancer effect. Healthy mice were tested for the acuate systemic toxicity. Our results showed that Alternol exerted a potent anti-cancer effect on 50 (83%) cancer cell lines with a GI Taken together, Alternol has a broad anti-cancer spectrum with a safe therapeutic index

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Copyright © 2024 He, Ma, Hirst, Li, Wu, Liu, Zhao, Xu, Godwin, Wang and Li.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.