[A case of hypereosinophilia with diffuse pulmonary nodules].

We reported a case of a 36-year-old woman who presented with cough, dyspnea, hypereosinophilia, multiple pulmonary nodules and mediastinal lymphadenopathy. The percentage of eosinophils in bronchoalveolar lavage fluid (BALF) was as high as 65%. Pathogenic tests and cytologic examination of BALF were negative. Transbronchial lung biopsy and endobronchial ultrasound-guided transbronchial needle aspiration revealed only eosinophil infiltration. As the patient responded poorly to high-dose corticosteroids, a surgical lung biopsy was performed. The pathological diagnosis was angioimmunoblastic T-cell lymphoma. The patient received chemotherapy and achieved a partial response. Her eosinophil count returned to the normal range, and the pulmonary nodules on chest CT partially resolved. 本文报道1例36岁女性患者，主要表现为咳嗽、气短、外周血嗜酸性粒细胞显著升高，胸部CT显示双肺多发结节、纵隔淋巴结肿大。先后两次支气管镜检查，镜下表现正常，肺泡灌洗液嗜酸性粒细胞比例升高，经支气管镜肺活检及纵隔淋巴结针吸活检提示肺组织及淋巴结内嗜酸性粒细胞浸润。因足量糖皮质激素治疗效果欠佳，行外科肺活检明确诊断为血管免疫母细胞性T细胞淋巴瘤。患者接受化疗后病情部分缓解，外周嗜酸性粒细胞降至正常，肺内结节明显减少。.