Differential radiological features of patients infected or colonised with slow-growing non-tuberculous mycobacteria.
Humans
Male
Female
Mycobacterium Infections, Nontuberculous
/ diagnostic imaging
Tomography, X-Ray Computed
/ methods
Aged
Middle Aged
Nontuberculous Mycobacteria
/ isolation & purification
Mycobacterium avium Complex
/ isolation & purification
Lung
/ microbiology
Retrospective Studies
Adult
Mycobacterium avium-intracellulare Infection
/ diagnostic imaging
Mycobacterium avium complex
Mycobacterium kansasii
Mycobacterium simiae
Mycobacterium xenopi
MAC
NTM
Non-tuberculous mycobacteria
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 06 2024
10 06 2024
Historique:
received:
19
01
2024
accepted:
04
06
2024
medline:
11
6
2024
pubmed:
11
6
2024
entrez:
10
6
2024
Statut:
epublish
Résumé
Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is considered a growing health concern. The majority of NTM-PD cases in Europe are caused by slow-growing mycobacteria (SGM). However, distinct radiological features of different SGM remain largely uninvestigated. We applied a previously described radiological score to a patient cohort consisting of individuals with isolation of different SGM. Correlations between clinical data, species and computed tomography (CT) features were examined by logistic and linear regression analyses, as well as over the course of time. Overall, 135 pulmonary CT scans from 84 patients were included. The isolated NTM-species were mainly Mycobacterium avium complex (MAC, n = 49), as well as 35 patients with non-MAC-species. Patients with isolation of M. intracellulare had more extensive CT findings compared to all other SGM species (coefficient 3.53, 95% Cl - 0.37 to 7.52, p = 0.075) while patients meeting the ATS criteria and not undergoing therapy exhibited an increase in CT scores over time. This study provides insights into differential radiological features of slow-growing NTM. While M. intracellulare exhibited a tendency towards higher overall CT scores, the radiological features were similar across different SGM. The applied CT score might be a useful instrument for monitoring patients and could help to guide antimycobacterial therapy.
Identifiants
pubmed: 38858499
doi: 10.1038/s41598-024-64029-0
pii: 10.1038/s41598-024-64029-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13295Informations de copyright
© 2024. The Author(s).
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