Transient brain activity dynamics discriminate levels of consciousness during anesthesia.

Consciousness / drug effects Animals Brain / physiology Magnetic Resonance Imaging Humans Anesthesia Male Macaca mulatta Adult Nerve Net / physiology Female Brain Mapping / methods

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
10 Jun 2024
Historique:
received: 20 10 2023
accepted: 15 05 2024
medline: 11 6 2024
pubmed: 11 6 2024
entrez: 10 6 2024
Statut: epublish

Résumé

The awake mammalian brain is functionally organized in terms of large-scale distributed networks that are constantly interacting. Loss of consciousness might disrupt this temporal organization leaving patients unresponsive. We hypothesize that characterizing brain activity in terms of transient events may provide a signature of consciousness. For this, we analyze temporal dynamics of spatiotemporally overlapping functional networks obtained from fMRI transient activity across different anesthetics and levels of anesthesia. We first show a striking homology in spatial organization of networks between monkeys and humans, indicating cross-species similarities in resting-state fMRI structure. We then track how network organization shifts under different anesthesia conditions in macaque monkeys. While the spatial aspect of the networks is preserved, their temporal dynamics are highly affected by anesthesia. Networks express for longer durations and co-activate in an anesthetic-specific configuration. Additionally, hierarchical brain organization is disrupted with a consciousness-level-signature role of the default mode network. In conclusion, large-scale brain network temporal dynamics capture differences in anesthetic-specific consciousness-level, paving the way towards a clinical translation of these cortical signature.

Identifiants

DOI: 10.1038/s42003-024-06335-x PMID: 38858589
pubmed: 38858589
doi: 10.1038/s42003-024-06335-x
pii: 10.1038/s42003-024-06335-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

716

Informations de copyright

© 2024. The Author(s).

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Auteurs

Scott Ensel (S)

Rehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.
Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.

Lynn Uhrig (L)

NeuroSpin Center, Institute of BioImaging Commissariat à l'Energie Atomique, Gif/Yvette, France.
Cognitive Neuroimaging Unit, INSERM, U992, Gif/Yvette, France.
Department of Anesthesiology and Critical Care, Necker Hospital, AP-HP, Université Paris Cité, Paris, France.

Ayberk Ozkirli (A)

Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
ORCID: 0000-0002-0882-4683

Guylaine Hoffner (G)

NeuroSpin Center, Institute of BioImaging Commissariat à l'Energie Atomique, Gif/Yvette, France.
Cognitive Neuroimaging Unit, INSERM, U992, Gif/Yvette, France.

Jordy Tasserie (J)

Harvard Medical School, Boston, MA, USA.
Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.

Stanislas Dehaene (S)

Cognitive Neuroimaging Unit, INSERM, U992, Gif/Yvette, France.
Collège de France, Paris, France.

Dimitri Van De Ville (D)

Neuro-X Institute, Ecole Polytechnique Fédérale de Lausanne, Geneva, Switzerland.
Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-2879-3861

Béchir Jarraya (B)

NeuroSpin Center, Institute of BioImaging Commissariat à l'Energie Atomique, Gif/Yvette, France.
Cognitive Neuroimaging Unit, INSERM, U992, Gif/Yvette, France.
Université Paris-Saclay (UVSQ), Saclay, France.
Neuroscience Pole, Foch Hospital, Suresnes, France.
ORCID: 0000-0003-0878-763X

Elvira Pirondini (E)

Rehab and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA. elvirap@pitt.edu.
Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA. elvirap@pitt.edu.
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. elvirap@pitt.edu.
Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland. elvirap@pitt.edu.
Department of Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA. elvirap@pitt.edu.
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA. elvirap@pitt.edu.
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. elvirap@pitt.edu.
ORCID: 0000-0002-8078-3951

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questionsmedicales.fr › Phénomènes psychologiques › Conscience › Transient brain activity dynamics discriminate...
questionsmedicales.fr › Eucaryotes › Animaux › Transient brain activity dynamics discriminate...
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