Surrogate gradient learning in spiking networks trained on event-based cytometry dataset.

Spiking neural networks (SNNs) are bio-inspired neural networks that - to an extent - mimic the workings of our brains. In a similar fashion, event-based vision sensors try to replicate a biological eye as closely as possible. In this work, we integrate both technologies for the purpose of classifying micro-particles in the context of label-free flow cytometry. We follow up on our previous work in which we used simple logistic regression with binary labels. Although this model was able to achieve an accuracy of over 98%, our goal is to utilize the system for a wider variety of cells, some of which may have less noticeable morphological variations. Therefore, a more advanced machine learning model like the SNNs discussed here would be required. This comes with the challenge of training such networks, since they typically suffer from vanishing gradients. We effectively apply the surrogate gradient method to overcome this issue achieving over 99% classification accuracy on test data for a four-class problem. Finally, rather than treating the neural network as a black box, we explore the dynamics inside the network and make use of that to enhance its accuracy and sparsity.