Zolbetuximab plus chemotherapy for locally advanced unresectable or metastatic stomach or gastroesophageal junction cancers: a plain language summary.

CLDN18.2+ HER2– lay summary locally advanced unresectable or metastatic stomach or gastroesophageal junction cancer plain language summary zolbetuximab

Journal

Future oncology (London, England)
ISSN: 1744-8301
Titre abrégé: Future Oncol
Pays: England
ID NLM: 101256629

Informations de publication

Date de publication:
24 May 2024
Historique:
medline: 11 6 2024
pubmed: 11 6 2024
entrez: 11 6 2024
Statut: aheadofprint

Résumé

This is a summary of two articles. The first article is about a clinical trial called SPOTLIGHT and it was published in the medical journal Until recently, In SPOTLIGHT and GLOW, on average, participants assigned to zolbetuximab plus chemotherapy lived 1.4 to 1.9 months longer before their tumors grew bigger or new tumors grew, after starting the trial, than participants assigned to a The clinical trials SPOTLIGHT and GLOW showed that, on average, participants with stomach or GEJ cancer assigned to zolbetuximab plus chemotherapy lived 2.2 to 2.7 months longer than participants assigned to a placebo plus chemotherapy.

Autres résumés

Type: plain-language-summary (eng)
The clinical trials SPOTLIGHT and GLOW showed that, on average, participants with stomach or GEJ cancer assigned to zolbetuximab plus chemotherapy lived 2.2 to 2.7 months longer than participants assigned to a placebo plus chemotherapy.

Identifiants

pubmed: 38861294
doi: 10.1080/14796694.2024.2342107
doi:

Banques de données

ClinicalTrials.gov
['NCT03504397', 'NCT03653507']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-17

Auteurs

Kohei Shitara (K)

Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa City, Chiba, Japan.

Manish A Shah (MA)

Weill Cornell Medical College, New York City, NY, USA.

Florian Lordick (F)

Department of Medicine & University Cancer Center Leipzig, University of Leipzig Medical Center, Leipzig, Germany.

Yung-Jue Bang (YJ)

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

David Ilson (D)

Memorial Sloan Kettering Cancer Center, New York City, NY, USA.

Eric Van Cutsem (EV)

Digestive Oncology, University Hospitals Gasthuisberg, Leuven, & KULeuven, Leuven, Belgium.

Peter Enzinger (P)

Center for Esophageal & Gastric Cancer, Dana-Farber Cancer Institute, Boston, MA, USA.

Sunnie S Kim (SS)

Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Samuel J Klempner (SJ)

Department of Medicine, Division of Hematology-Oncology, Massachusetts General Cancer Center, Boston, MA, USA.

Diarmuid Moran (D)

Astellas Pharma Global Development, Inc., Northbrook, IL, USA.

Jung Wook Park (JW)

Astellas Pharma Global Development, Inc., Northbrook, IL, USA.

Pranob Bhattacharya (P)

Astellas Pharma Global Development, Inc., Northbrook, IL, USA.

Jaffer A Ajani (JA)

The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

Rui-Hua Xu (RH)

Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Classifications MeSH