Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew.

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
11 Jun 2024
Historique:
received: 03 02 2023
accepted: 03 06 2024
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 11 6 2024
Statut: aheadofprint

Résumé

Human spaceflight has historically been managed by government agencies, such as the NASA Twins Study

Identifiants

DOI: 10.1038/s41586-024-07648-x PMID: 38862026
pubmed: 38862026
doi: 10.1038/s41586-024-07648-x
pii: 10.1038/s41586-024-07648-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

Auteurs

C W Jones (CW)

Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0002-8173-721X

E G Overbey (EG)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
Center for STEM, University of Austin, Austin, TX, USA.
ORCID: 0000-0002-2866-8294

J Lacombe (J)

Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
Department of Basic Medical Sciences; College of Medicine Phoenix, University of Arizona, Phoenix, AZ, USA.

A J Ecker (AJ)

Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

C Meydan (C)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-0663-6216

K Ryon (K)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.

B Tierney (B)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-7533-8802

N Damle (N)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.

M MacKay (M)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.

E E Afshin (EE)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.

J Foox (J)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA.

J Park (J)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-0045-1429

T Nelson (T)

Department of Microbiology & Immunology, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
ORCID: 0000-0002-8600-0444

M Suhail (M)

TrialX Inc., New York, NY, USA.

S G Byhaqui (SG)

TrialX Inc., New York, NY, USA.

B Aslam (B)

TrialX Inc., New York, NY, USA.

U A Tali (UA)

TrialX Inc., New York, NY, USA.

L Nisa (L)

TrialX Inc., New York, NY, USA.

P Menon (P)

TrialX Inc., New York, NY, USA.

C O Patel (CO)

TrialX Inc., New York, NY, USA.

S A Khan (SA)

TrialX Inc., New York, NY, USA.

D J Ebert (DJ)

KBR, Science & Space, Houston, TX, USA.

A Everson (A)

KBR, Science & Space, Houston, TX, USA.

M C Schubert (MC)

Department of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

N N Ali (NN)

Department of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

M S Sarma (MS)

Department of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0002-6693-9382

J Kim (J)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-8733-9925

N Houerbi (N)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

K Grigorev (K)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-3628-0123

S Garcia Medina (S)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

A J Summers (AJ)

Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
ORCID: 0000-0002-7372-0610

J Gu (J)

Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
Department of Basic Medical Sciences; College of Medicine Phoenix, University of Arizona, Phoenix, AZ, USA.

J A Altin (JA)

The Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.

A Fattahi (A)

Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
ORCID: 0000-0001-8226-5835

M I Hirzallah (MI)

Departments of Neurology and Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
ORCID: 0000-0003-0542-8025

J H Wu (JH)

Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
Translational Research Institute for Space Health, Houston, TX, USA.

A C Stahn (AC)

Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
ORCID: 0000-0002-4030-4944

A Beheshti (A)

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Blue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
ORCID: 0000-0003-4643-531X

R Klotz (R)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

V Ortiz (V)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

M Yu (M)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

L Patras (L)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania.

I Matei (I)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-5712-8430

D Lyden (D)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-0193-4131

A Melnick (A)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-8074-2287

N Banerjee (N)

SpaceX, Hawthorne, CA, USA.
ORCID: 0000-0002-6825-917X

S Mullane (S)

SpaceX, Hawthorne, CA, USA.

A Kleinman (A)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

M Loesche (M)

SpaceX, Hawthorne, CA, USA.

A S Menon (AS)

University of Texas, Department of Emergency Medicine, Houston, TX, USA.
ORCID: 0000-0002-6886-3553

D B Donoviel (DB)

Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
Translational Research Institute for Space Health, Houston, TX, USA.

E Urquieta (E)

Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.
Translational Research Institute for Space Health, Houston, TX, USA.

J Mateus (J)

SpaceX, Hawthorne, CA, USA.

A E Sargsyan (AE)

KBR, Science & Space, Houston, TX, USA.

M Shelhamer (M)

Department of Otolaryngology - Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

F Zenhausern (F)

Center for Applied Nanobioscience and Medicine, College of Medicine-Phoenix, University of Arizona, Phoenix, AZ, USA.
Department of Basic Medical Sciences; College of Medicine Phoenix, University of Arizona, Phoenix, AZ, USA.
The Translational Genomics Research Institute (TGen), Phoenix and Flagstaff, AZ, USA.
Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.

E M Bershad (EM)

Departments of Neurology and Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA.

M Basner (M)

Unit for Experimental Psychiatry, Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. basner@pennmediicne.upenn.edu.
ORCID: 0000-0002-8453-0812

C E Mason (CE)

Department of Physiology, Biophysics and Medicine, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.
The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.
ORCID: 0000-0002-1850-1642

Classifications MeSH