The Space Omics and Medical Atlas (SOMA) and international astronaut biobank.

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
11 Jun 2024
Historique:
received: 30 12 2022
accepted: 31 05 2024
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 11 6 2024
Statut: aheadofprint

Résumé

Spaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space

Identifiants

DOI: 10.1038/s41586-024-07639-y PMID: 38862028
pubmed: 38862028
doi: 10.1038/s41586-024-07639-y
pii: 10.1038/s41586-024-07639-y
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

Auteurs

Eliah G Overbey (EG)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. elo4004@med.cornell.edu.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. elo4004@med.cornell.edu.
BioAstra, Inc, New York, NY, USA. elo4004@med.cornell.edu.
Center for STEM, University of Austin, Austin, TX, USA. elo4004@med.cornell.edu.
ORCID: 0000-0002-2866-8294

JangKeun Kim (J)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-8733-9925

Braden T Tierney (BT)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-7533-8802

Jiwoon Park (J)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-0045-1429

Nadia Houerbi (N)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

Alexander G Lucaci (AG)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

Sebastian Garcia Medina (SG)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

Namita Damle (N)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Deena Najjar (D)

Albert Einstein College of Medicine, Bronx, NY, USA.
ORCID: 0009-0009-7950-2866

Kirill Grigorev (K)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

Evan E Afshin (EE)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

Krista A Ryon (KA)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Karolina Sienkiewicz (K)

The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Tri-Institutional Biology and Medicine program, Weill Cornell Medicine, New York, NY, USA.

Laura Patras (L)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Department of Molecular Biology and Biotechnology, Center of Systems Biology, Biodiversity and Bioresources, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania.

Remi Klotz (R)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
ORCID: 0000-0003-2100-0635

Veronica Ortiz (V)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Matthew MacKay (M)

Tri-Institutional Biology and Medicine program, Weill Cornell Medicine, New York, NY, USA.

Annalise Schweickart (A)

The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Tri-Institutional Biology and Medicine program, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0001-9691-3741

Christopher R Chin (CR)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-2140-3197

Maria A Sierra (MA)

Tri-Institutional Biology and Medicine program, Weill Cornell Medicine, New York, NY, USA.

Matias F Valenzuela (MF)

Buck Institute for Research on Aging, Novato, CA, USA.

Ezequiel Dantas (E)

Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-4934-4632

Theodore M Nelson (TM)

Department of Microbiology & Immunology, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
ORCID: 0000-0002-8600-0444

Egle Cekanaviciute (E)

Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
ORCID: 0000-0003-3306-1806

Gabriel Deards (G)

Tri-Institutional Biology and Medicine program, Weill Cornell Medicine, New York, NY, USA.

Jonathan Foox (J)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

S Anand Narayanan (SA)

Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.

Caleb M Schmidt (CM)

Sovaris Aerospace, Boulder, Colorado, USA.
Advanced Pattern Analysis and Human Performance Group, Boulder, Colorado, USA.
Department of Systems Engineering, Colorado State University, Fort Collins, Colorado, USA.

Michael A Schmidt (MA)

Sovaris Aerospace, Boulder, Colorado, USA.
Advanced Pattern Analysis and Human Performance Group, Boulder, Colorado, USA.

Julian C Schmidt (JC)

Sovaris Aerospace, Boulder, Colorado, USA.
Advanced Pattern Analysis and Human Performance Group, Boulder, Colorado, USA.

Sean Mullane (S)

Space Exploration Technologies Corporation (SpaceX), Hawthorne, CA, USA.

Seth Stravers Tigchelaar (SS)

Space Exploration Technologies Corporation (SpaceX), Hawthorne, CA, USA.

Steven Levitte (S)

Space Exploration Technologies Corporation (SpaceX), Hawthorne, CA, USA.
Division of Pediatric Gastroenterology, Stanford University, Palo Alto, CA, USA.

Craig Westover (C)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Chandrima Bhattacharya (C)

Tri-Institutional Biology and Medicine program, Weill Cornell Medicine, New York, NY, USA.

Serena Lucotti (S)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.

Jeremy Wain Hirschberg (JW)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Jacqueline Proszynski (J)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Marissa Burke (M)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0001-5647-3358

Ashley Kleinman (A)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Daniel J Butler (DJ)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Conor Loy (C)

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

Omary Mzava (O)

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

Joan Lenz (J)

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

Doru Paul (D)

Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.

Christopher Mozsary (C)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.

Lauren M Sanders (LM)

Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.

Lynn E Taylor (LE)

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.

Chintan O Patel (CO)

TrialX Inc., New York, NY, USA.

Sharib A Khan (SA)

TrialX Inc., New York, NY, USA.

Mir Suhail (M)

TrialX Inc., New York, NY, USA.

Syed G Byhaqui (SG)

TrialX Inc., New York, NY, USA.

Burhan Aslam (B)

TrialX Inc., New York, NY, USA.

Aaron S Gajadhar (AS)

Seer, Inc., Redwood City, CA, USA.

Lucy Williamson (L)

Seer, Inc., Redwood City, CA, USA.

Purvi Tandel (P)

Seer, Inc., Redwood City, CA, USA.

Qiu Yang (Q)

Seer, Inc., Redwood City, CA, USA.

Jessica Chu (J)

Seer, Inc., Redwood City, CA, USA.

Ryan W Benz (RW)

Seer, Inc., Redwood City, CA, USA.

Asim Siddiqui (A)

Seer, Inc., Redwood City, CA, USA.

Daniel Hornburg (D)

Seer, Inc., Redwood City, CA, USA.
ORCID: 0000-0002-6618-7774

Kelly Blease (K)

Element Biosciences, San Diego, CA, USA.

Juan Moreno (J)

Element Biosciences, San Diego, CA, USA.

Andrew Boddicker (A)

Element Biosciences, San Diego, CA, USA.
ORCID: 0000-0001-7957-8283

Junhua Zhao (J)

Element Biosciences, San Diego, CA, USA.
ORCID: 0009-0006-7672-1084

Bryan Lajoie (B)

Element Biosciences, San Diego, CA, USA.

Ryan T Scott (RT)

KBR; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
ORCID: 0000-0003-0654-5661

Rachel R Gilbert (RR)

KBR; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.

San-Huei Lai Polo (SL)

KBR; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.

Andrew Altomare (A)

Element Biosciences, San Diego, CA, USA.

Semyon Kruglyak (S)

Element Biosciences, San Diego, CA, USA.

Shawn Levy (S)

Element Biosciences, San Diego, CA, USA.

Ishara Ariyapala (I)

Alamar Biosciences, Inc, 47071 Bayside Parkway, Fremont, CA, USA.

Joanne Beer (J)

Alamar Biosciences, Inc, 47071 Bayside Parkway, Fremont, CA, USA.
ORCID: 0000-0001-8583-8467

Bingqing Zhang (B)

Alamar Biosciences, Inc, 47071 Bayside Parkway, Fremont, CA, USA.

Briana M Hudson (BM)

NanoString Technologies, Seattle, WA, USA.

Aric Rininger (A)

NanoString Technologies, Seattle, WA, USA.

Sarah E Church (SE)

NanoString Technologies, Seattle, WA, USA.
ORCID: 0000-0002-7194-4282

Afshin Beheshti (A)

Blue Marble Space Institute of Science; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0003-4643-531X

George M Church (GM)

Harvard Medical School and the Wyss Institute, Boston, MA, USA.
ORCID: 0000-0001-6232-9969

Scott M Smith (SM)

National Aeronautics and Space Administration, Johnson Space Center, Human Health and Performance Directorate, Biomedical Research and Environmental Sciences Division, Houston, TX, USA.
ORCID: 0000-0001-9313-7900

Brian E Crucian (BE)

National Aeronautics and Space Administration, Johnson Space Center, Human Health and Performance Directorate, Biomedical Research and Environmental Sciences Division, Houston, TX, USA.

Sara R Zwart (SR)

University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0001-8694-0180

Irina Matei (I)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-5712-8430

David C Lyden (DC)

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.
Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-0193-4131

Francine Garrett-Bakelman (F)

Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA.
Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA, USA.

Jan Krumsiek (J)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Tri-Institutional Biology and Medicine program, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0003-4734-3791

Qiuying Chen (Q)

Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.

Dawson Miller (D)

Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.

Joe Shuga (J)

10x Genomics, Pleasanton, CA, USA.

Stephen Williams (S)

10x Genomics, Pleasanton, CA, USA.

Corey Nemec (C)

10x Genomics, Pleasanton, CA, USA.
ORCID: 0000-0002-6566-1753

Guy Trudel (G)

Bone and Joint Research Laboratory, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.
Department of Medicine, Division of Physiatry, The Ottawa Hospital, Room 2505G, 505 Smyth Road, Ottawa, Ontario, Canada.
Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Room 1321, Ottawa, Ontario, Canada.
ORCID: 0000-0001-5254-4294

Martin Pelchat (M)

Department of Biochemistry, Microbiology, and Immunology, Roger Guindon Hall, Room 4111A, University of Ottawa, Ottawa, Canada.

Odette Laneuville (O)

Department of Biology, Gendron Hall Room 3-372, University of Ottawa, Ottawa, Canada.
ORCID: 0000-0003-3124-3892

Iwijn De Vlaminck (I)

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
ORCID: 0000-0001-6085-7311

Steven Gross (S)

Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.

Kelly L Bolton (KL)

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

Susan M Bailey (SM)

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO, USA.
ORCID: 0000-0001-5595-9364

Richard Granstein (R)

Department of Dermatology, Weill Cornell Medicine, New York, NY, USA.

David Furman (D)

Buck Institute for Research on Aging, Novato, CA, USA.
Cosmica Biosciences Inc., San Francisco, CA, USA.
Stanford 1000 Immunomes Project, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
Institute for Research in Translational Medicine, Universidad Austral, CONICET, Pilar, Buenos Aires, Argentina.
ORCID: 0000-0002-3654-9519

Ari M Melnick (AM)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
ORCID: 0000-0002-8074-2287

Sylvain V Costes (SV)

Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
ORCID: 0000-0002-8542-2389

Bader Shirah (B)

Department of Neuroscience, King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia.
ORCID: 0000-0001-6493-2155

Min Yu (M)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Anil S Menon (AS)

University of Texas Medical Branch, Galveston, TX, USA.
ORCID: 0000-0002-6886-3553

Jaime Mateus (J)

Space Exploration Technologies Corporation (SpaceX), Hawthorne, CA, USA.

Cem Meydan (C)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. cem2009@med.cornell.edu.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. cem2009@med.cornell.edu.
Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. cem2009@med.cornell.edu.
ORCID: 0000-0002-0663-6216

Christopher E Mason (CE)

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.
The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.
BioAstra, Inc, New York, NY, USA. chm2042@med.cornell.edu.
The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, NY, USA. chm2042@med.cornell.edu.
WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.
ORCID: 0000-0002-1850-1642

Classifications MeSH