3-Position Biaryl Endochin-like Quinolones with Enhanced Antimalarial Performance.

antimalarial drug next-generation ELQs oral prophylaxis structure−activity relationships

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
11 Jun 2024
Historique:
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 11 6 2024
Statut: aheadofprint

Résumé

ELQ-300 is a potent antimalarial drug with activity against blood, liver, and vector stages of the disease. A prodrug,

Identifiants

DOI: 10.1021/acsinfecdis.4c00140 PMID: 38862127
pubmed: 38862127
doi: 10.1021/acsinfecdis.4c00140
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Sovitj Pou (S)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.

Rolf W Winter (RW)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.

Rozalia A Dodean (RA)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
ORCID: 0000-0001-5002-4607

Katherine Liebman (K)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.

Yuexin Li (Y)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.

Michael W Mather (MW)

Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States.

Binod Nepal (B)

Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States.

Aaron Nilsen (A)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.
ORCID: 0000-0002-3827-8222

Mason J Handford (MJ)

Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.

Teresa M Riscoe (TM)

Department of Microbiology and Molecular Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.

Sydney Laxson (S)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.

Payton J Kirtley (PJ)

Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States.

Maya Aleshnick (M)

Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States.

Lev N Zakharov (LN)

Center for Advanced Materials Characterization in Oregon (CAMCOR), 1443 E. 13th Avenue, Eugene, Oregon 97403, United States.

Jane X Kelly (JX)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
ORCID: 0000-0001-8871-0207

Martin J Smilkstein (MJ)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.

Brandon K Wilder (BK)

Vaccine & Gene Therapy Institute (VGTI), Oregon Health and Science University (West Campus), 505 NW 185th Avenue, #1, Beaverton, Oregon 97006, United States.

Sandhya Kortagere (S)

Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States.

Akhil B Vaidya (AB)

Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, United States.
ORCID: 0000-0003-1063-5571

P Holland Alday (PH)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
School of Medicine Division of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.
ORCID: 0000-0002-0142-2438

J Stone Doggett (JS)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
School of Medicine Division of Infectious Diseases, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.
ORCID: 0000-0002-6098-1520

Michael K Riscoe (MK)

VA Portland Healthcare System, 3710 SW US Veterans Hospital Road, Portland, Oregon 97239, United States.
Department of Microbiology and Molecular Immunology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, United States.
ORCID: 0000-0002-1343-5279

Classifications MeSH