Ethical considerations for the age of non-governmental space exploration.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 Jun 2024
11 Jun 2024
Historique:
received:
11
12
2022
accepted:
05
12
2023
medline:
12
6
2024
pubmed:
12
6
2024
entrez:
11
6
2024
Statut:
epublish
Résumé
Mounting ambitions and capabilities for public and private, non-government sector crewed space exploration bring with them an increasingly diverse set of space travelers, raising new and nontrivial ethical, legal, and medical policy and practice concerns which are still relatively underexplored. In this piece, we lay out several pressing issues related to ethical considerations for selecting space travelers and conducting human subject research on them, especially in the context of non-governmental and commercial/private space operations.
Identifiants
pubmed: 38862473
doi: 10.1038/s41467-023-44357-x
pii: 10.1038/s41467-023-44357-x
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4774Subventions
Organisme : National Aeronautics and Space Administration (NASA)
ID : 80NSSC19K0883
Informations de copyright
© 2024. The Author(s).
Références
Inspiration4 - Home. Inspiration4 https://inspiration4.com , https://inspiration4.com .
NASA Selects First Commercial Destination Module for International Space Station - NASA. https://www.nasa.gov/news-release/nasa-selects-first-commercial-destination-module-for-international-space-station/ .
Available Flight Platforms - NASA. https://www.nasa.gov/stmd-flight-opportunities/available-flight-platforms/ .
Falcon 9: First Orbital Class Rocket Capable of Reflight. SpaceX https://www.spacex.com/vehicles/falcon-9/ .
Rep. Akaka, D. K. [D-H.−2. H.R.3942 − 98th Congress (1983-1984): Commercial Space Launch Act. https://www.congress.gov/bill/98th-congress/house-bill/3942 (1984).
United Nations Office for Outer Space Affairs. United Nations Treaties and Principles on Outer Space. Doc. Outer Space Law (2008).
Meet the dearMoon Crew! Meet the dearMoon Crew! https://dearmoon.earth/ .
Polaris Program. Polaris Program https://polarisprogram.com/ .
Kluge, G. et al. Commercial suborbital space tourism-proposal on passenger’s medical selection. Acta Astronaut. 92, 187–192 (2013).
doi: 10.1016/j.actaastro.2012.08.005
Arnould, J. Icarus’ Second Chance: The Basis and Perspectives of Space Ethics. vol. 6 (Springer, 2011).
Coleman, D. S. & Miller, C. D. L. Military Space Ethics. (Howgate Publishing Limited, 2022).
Galliott, J. Commercial Space Exploration: Ethics, Policy and Governance. (Routledge, 2016). https://doi.org/10.4324/9781315572857 .
Green, B. Space Ethics. (Rowman & Littlefield, 2021).
Schwartz, J. S. J. & Milligan, T. The Ethics of Space Exploration. (Springer, 2016).
Steer, C. & Hersch, M. War and Peace in Outer Space: Law, Policy, and Ethics. (Oxford University Press, 2021).
Lawton, A., Wal, Z. van der & Huberts, L. Ethics in Public Policy and Management: A global research companion. (Routledge, 2015).
Rycroft, M. J. Beyond the International Space Station: The Future of Human Spaceflight: Proceedings of an International Symposium, 4–7 June 2002, Strasbourg, France. (Springer, 2013).
Gibson, T. M. The bioethics of enhancing human performance for spaceflight. J. Med. Ethics 32, 129–132 (2006).
pubmed: 16507654
pmcid: 2564462
doi: 10.1136/jme.2005.012534
Milligan, T. Nobody Owns the Moon: The Ethics of Space Exploitation. (McFarland & Company, 2015).
Cucinotta, F. A., Cacao, E., Kim, M.-H. Y. & Saganti, P. B. Cancer and circulatory disease risks for a human mission to Mars: Private mission considerations. Acta Astronaut 166, 529–536 (2020).
doi: 10.1016/j.actaastro.2018.08.022
NASA Spaceflight Human-System Standard Volume 1, Crew Health | Standards. https://standards.nasa.gov/standard/NASA/NASA-STD-3001-VOL-1 .
Langston, S. M. Space Travel: Risk, Ethics, and Governance in Commercial Human Spaceflight. N. Space 4, 83–97 (2016).
doi: 10.1089/space.2015.0015
Langston, S. M. Commercial space travel understanding the legal, ethical and medical implications for commercial spaceflight participants and crew. in 2017 8th International Conference on Recent Advances in Space Technologies (RAST) 489–494 https://doi.org/10.1109/RAST.2017.8002956 (2017).
14 C. F. R. Part 460 -- Human Space Flight Requirements. https://www.ecfr.gov/current/title-14/part-460 .
Nelson, G. A. Space radiation and human exposures, a primer. Radiat. Res. 185, 349–358 (2016).
pubmed: 27018778
doi: 10.1667/RR14311.1
Demontis, G. C. et al. Human pathophysiological adaptations to the space environment. Front. Physiol. 8, 547 (2017).
pubmed: 28824446
pmcid: 5539130
doi: 10.3389/fphys.2017.00547
Pagel, J. I. & Choukèr, A. Effects of isolation and confinement on humans-implications for manned space explorations. J. Appl. Physiol. 120, 1449–1457 (2016).
pubmed: 26846554
doi: 10.1152/japplphysiol.00928.2015
Afshinnekoo, E. et al. Fundamental biological features of spaceflight: advancing the field to enable deep-space exploration. Cell 183, 1162–1184 (2020).
pubmed: 33242416
pmcid: 8441988
doi: 10.1016/j.cell.2020.10.050
Space Radiation and Astronaut Health: Managing and Communicating Cancer Risks. (National Academies Press, 2021). https://doi.org/10.17226/26155 .
Garrett-Bakelman, F. E. et al. The NASA twins study: a multidimensional analysis of a year-long human spaceflight. Science 364, eaau8650 (2019).
pubmed: 30975860
pmcid: 7580864
doi: 10.1126/science.aau8650
Voorhies, A. A. et al. Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome. Sci. Rep. 9, 9911 (2019).
pubmed: 31289321
pmcid: 6616552
doi: 10.1038/s41598-019-46303-8
da Silveira, W. A. et al. Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact. Cell 183, 1185–1201 e20 (2020).
pubmed: 33242417
pmcid: 7870178
doi: 10.1016/j.cell.2020.11.002
Goodwin, T. J. & Christofidou-Solomidou, M. Oxidative stress and space biology: an organ-based approach. Int. J. Mol. Sci. 19, 959 (2018).
pubmed: 29570635
pmcid: 5979446
doi: 10.3390/ijms19040959
Gertz, M. L. et al. Multi-omic, single-cell, and biochemical profiles of astronauts guide pharmacological strategies for returning to gravity. Cell Rep. 33, 108429 (2020).
pubmed: 33242408
pmcid: 9444344
doi: 10.1016/j.celrep.2020.108429
Patel, S. The effects of microgravity and space radiation on cardiovascular health: From low-Earth orbit and beyond. Int. J. Cardiol. Heart Vasc. 30, 100595 (2020).
pubmed: 32775602
pmcid: 7399104
Ricci, F., De Caterina, R. & Fedorowski, A. Orthostatic Hypotension: Epidemiology, Prognosis, and Treatment. J. Am. Coll. Cardiol. 66, 848–860 (2015).
van Loon, L. M., Steins, A., Schulte, K.-M., Gruen, R. & Tucker, E. M. Computational modeling of orthostatic intolerance for travel to Mars. Npj Microgravity 8, 1–10 (2022).
Auñón-Chancellor, S. M., Pattarini, J. M., Moll, S. & Sargsyan, A. Venous Thrombosis during Spaceflight. N. Engl. J. Med. 382, 89–90 (2020).
Marshall-Goebel, K. et al. Assessment of jugular venous blood flow stasis and thrombosis during spaceflight. JAMA Netw. Open 2, e1915011 (2019).
pubmed: 31722025
pmcid: 6902784
doi: 10.1001/jamanetworkopen.2019.15011
Prasad, B. et al. Influence of microgravity on apoptosis in cells, tissues, and other systems in vivo and in vitro. Int. J. Mol. Sci. 21, 9373 (2020).
pubmed: 33317046
pmcid: 7764784
doi: 10.3390/ijms21249373
Grimm, D. et al. The impact of microgravity on bone in humans. Bone 87, 44–56 (2016).
pubmed: 27032715
doi: 10.1016/j.bone.2015.12.057
Orwoll, E. S. et al. Skeletal health in long-duration astronauts: nature, assessment, and management recommendations from the NASA Bone. Summit J. Bone Miner. Res. J. Am. Soc. Bone Miner. Res. 28, 1243–1255 (2013).
doi: 10.1002/jbmr.1948
Lee, A. G. et al. Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update. Npj Microgravity 6, 1–10 (2020).
Patel, Z. S. et al. Red risks for a journey to the red planet: the highest priority human health risks for a mission to Mars. Npj Microgravity 6, 1–13 (2020).
doi: 10.1038/s41526-020-00124-6
Guo, Z., Zhou, G. & Hu, W. Carcinogenesis induced by space radiation: a systematic review. Neoplasia N. Y. N. 32, 100828 (2022).
doi: 10.1016/j.neo.2022.100828
Costes, S. V., Chiolo, I., Pluth, J. M., Barcellos-Hoff, M. H. & Jakob, B. Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutat. Res. 704, 78–87 (2010).
pubmed: 20060491
pmcid: 3951968
doi: 10.1016/j.mrrev.2009.12.006
Bogomolov, V. V. et al. International space Station medical standards and certification for space flight participants. Aviat. Space Environ. Med. 78, 1162–1169 (2007).
pubmed: 18064923
Garcia, A. M. Multilateral Coordination Board Joint Statement. https://blogs.nasa.gov/spacestation/2022/08/10/multilateral-coordination-board-joint-statement/ (2022).
Aerospace medical association commercial spaceflight working group. Suborbital commercial spaceflight crewmember medical issues. Aviat. Space Environ. Med. 82, 475–484 (2011).
Zheng, M. et al. Time-resolved molecular measurements reveal changes in astronauts during spaceflight. Front. Physiol. 14, 1219221 (2023).
pubmed: 37520819
pmcid: 10376710
doi: 10.3389/fphys.2023.1219221
Brooks, A. et al. Report No. 167 – Potential Impact of Individual Genetic Susceptibility and Previous Radiation Exposure on Radiation Risk for Astronauts (2010) - NCRP | Bethesda, MD. https://ncrponline.org/shop/reports/report-no-167-potential-impact-of-individual-genetic-susceptibility-and-previous-radiation-exposure-on-radiation-risk-for-astronauts/ (2018).
WMA - The world medical association-declaration of helsinki. https://www.wma.net/what-we-do/medical-ethics/declaration-of-helsinki/ .
Schücklenk, U. & Ashcroft, R. International research ethics. Bioethics 14, 158–172 (2000).
doi: 10.1111/1467-8519.00187
Lie, R. K., Emanuel, E., Grady, C. & Wendler, D. The standard of care debate: the Declaration of Helsinki versus the international consensus opinion. J. Med. Ethics 30, 190–193 (2004).
pubmed: 15082816
pmcid: 1733825
doi: 10.1136/jme.2003.006031
Schüklenk, U. The standard of care debate: against the myth of an “international consensus opinion”. J. Med. Ethics 30, 194–197 (2004).
pubmed: 15082817
pmcid: 1733846
doi: 10.1136/jme.2003.006981
Macklin, R. After Helsinki: unresolved issues in international research. Kennedy Inst. Ethics J. 11, 17–36 (2001).
pubmed: 12166444
doi: 10.1353/ken.2001.0005
Wolinsky, H. The battle of Helsinki: Two troublesome paragraphs in the Declaration of Helsinki are causing a furore over medical research ethics. EMBO Rep. 7, 670–672 (2006).
pubmed: 16819460
pmcid: 1500825
doi: 10.1038/sj.embor.7400743
Outer Space Treaty. https://www.unoosa.org/oosa/en/ourwork/spacelaw/treaties/outerspacetreaty.html .
Pace, S. Alternative futures for crewed space cooperation after the international space station. J. Space Saf. Eng. 10, 88–94 (2023).
doi: 10.1016/j.jsse.2022.11.002
Crowther, R. The regulatory challenges of ensuring commercial human spaceflight safety. Space Policy 27, 74–76 (2011).
doi: 10.1016/j.spacepol.2011.04.011
Federal aviation administration. Recommended Practices for Human Space Flight Occupant Safety - Version 2.0. 102 https://www.faa.gov/media/71481 (2023).
Grenon, S. M., Saary, J., Gray, G., Vanderploeg, J. M. & Hughes-Fulford, M. Can I take a space flight? Considerations for doctors. BMJ 345, e8124 (2012).
pubmed: 23241271
pmcid: 4688424
doi: 10.1136/bmj.e8124
Langston, S. Reimagining Icarus: Ethics, law and policy considerations for commercial human spaceflight. Space Journey Hum. Adapt Live Microgravity https://doi.org/10.5772/intechopen.74716 (2018).
49 CFR 391.47 -- Resolution of conflicts of medical evaluation. https://www.ecfr.gov/current/title-49/part-391/section-391.47 .
Dworkin, G. Paternalism. in The Stanford Encyclopedia of Philosophy (2002).
Locke, P. A. & Weil, M. M. Personalized cancer risk assessments for space radiation exposures. Front. Oncol. 6, 38 (2016).
pubmed: 26942127
pmcid: 4762001
doi: 10.3389/fonc.2016.00038
Rosenfeld, J. A., Mason, C. E. & Smith, T. M. Limitations of the human reference genome for personalized genomics. PLOS ONE 7, e40294 (2012).
pubmed: 22811759
pmcid: 3394790
doi: 10.1371/journal.pone.0040294
Putcha, L., Berens, K. L., Marshburn, T. H., Ortega, H. J. & Billica, R. D. Pharmaceutical use by U.S. astronauts on space shuttle missions. Aviat. Space Environ. Med. 70, 705–708 (1999).
pubmed: 10417009
Barger, L. K. et al. Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study. Lancet Neurol. 13, 904–912 (2014).
pubmed: 25127232
pmcid: 4188436
doi: 10.1016/S1474-4422(14)70122-X
Blue, R. S. et al. Supplying a pharmacy for NASA exploration spaceflight: challenges and current understanding. Npj Microgravity 5, 1–12 (2019).
doi: 10.1038/s41526-019-0075-2
Langston, S. M. Suborbital Flights: a comparative analysis of national and international law. J. Space Law 37, 299 (2011).
Kluger, J. Apollo 8: The Thrilling Story of the First Mission to the Moon. (Henry Holt and Co., 2017).
Nangle, S. N. et al. The case for biotech on Mars. Nat. Biotechnol. 38, 401–407 (2020).
pubmed: 32265561
doi: 10.1038/s41587-020-0485-4
The Genetic Information Nondiscrimination Act of 2008. US EEOC https://www.eeoc.gov/statutes/genetic-information-nondiscrimination-act-2008 .
NASA Policy Directive - Use of Human Research Genetic Testing. https://nodis3.gsfc.nasa.gov/displayDir.cfm?t=NPD&c=7170&s=1 (2017).
Pagnini, F. et al. Human behavior and performance in deep space exploration: next challenges and research gaps. NPJ Microgravity 9, 27 (2023).
Sishc, B. J. et al. The need for biological countermeasures to mitigate the risk of space radiation-induced carcinogenesis, cardiovascular disease, and central nervous system deficiencies. Life Sci. Space Res 35, 4–8 (2022).
doi: 10.1016/j.lssr.2022.06.003
Blue, R. S., Jennings, R. T., Antunano, M. J. & Mathers, C. H. Commercial spaceflight: progress and challenges in expanding human access to space. REACH 7–8, 6–13 (2017).
doi: 10.1016/j.reach.2018.08.001
Jennings, R. T. et al. Medical qualification of a commercial spaceflight participant: not your average astronaut. Aviat. Space Environ. Med. 77, 475–484 (2006).
pubmed: 16708526
Barratt, M. R. Comments on medical qualification of space tourists. Aviat. Space Environ. Med. 77, 485 (2006).
pubmed: 16708527
Bokhari, R. S. et al. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci. Space Res 35, 105–112 (2022).
doi: 10.1016/j.lssr.2022.08.003
Federal policy for the protection of human subjects. Federal Register https://www.federalregister.gov/documents/2017/01/19/2017-01058/federal-policy-for-the-protection-of-human-subjects (2017).
Marsh, M. Ethical and medical dilemmas of space tourism. Adv. Space Res. 37, 1823–1827 (2006).
doi: 10.1016/j.asr.2006.03.001
Pavez Loriè, E. et al. The future of personalized medicine in space: from observations to countermeasures. Front. Bioeng. Biotechnol. 9, 739747 (2021).
Health Standards for Long Duration and Exploration Spaceflight: Ethics Principles, Responsibilities, and Decision Framework. (National Academies Press, 2014). https://doi.org/10.17226/18576 .
Ritsher, J., Kanas, N. & Saylor, S. Maintaining Privacy During Psychosocial Research on the International Space Station. J. Hum. Perform. Extreme Environ. 8, Article 3 (2005).
Reed, R. D. & Antonsen, E. L. Should NASA Collect Astronauts’ Genetic Information for Occupational Surveillance and Research? AMA J. Ethics 20, 849–856 (2018).
doi: 10.1001/amajethics.2018.849
NASA Guidelines for Promoting Scientific and Research Integrity. https://www.nasa.gov/sites/default/files/atoms/files/nasa_guidelines_for_promoting_scientific_and_research_integrity-july_2018.pdf (2018).
Council for International Organizations of Medical Sciences (CIOMS). 2016 International ethical guidelines for health-related research involving humans. (Geneva, 2016).