Resting state neurophysiology of agonist-antagonist myoneural interface in persons with transtibial amputation.

Humans Amputation, Surgical Magnetic Resonance Imaging Male Female Adult Middle Aged Rest / physiology Tibia / surgery Brain / physiopathology Neurophysiology / methods Amputees / rehabilitation Brain Mapping / methods

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
12 Jun 2024
Historique:
received: 06 04 2024
accepted: 24 05 2024
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 11 6 2024
Statut: epublish

Résumé

The agonist-antagonist myoneural interface (AMI) is an amputation surgery that preserves sensorimotor signaling mechanisms of the central-peripheral nervous systems. Our first neuroimaging study investigating AMI subjects conducted by Srinivasan et al. (2020) focused on task-based neural signatures, and showed evidence of proprioceptive feedback to the central nervous system. The study of resting state neural activity helps non-invasively characterize the neural patterns that prime task response. In this study on resting state functional magnetic resonance imaging in AMI subjects, we compared functional connectivity in patients with transtibial AMI (n = 12) and traditional (n = 7) amputations (TA). To test our hypothesis that we would find significant neurophysiological differences between AMI and TA subjects, we performed a whole-brain exploratory analysis to identify a seed region; namely, we conducted ANOVA, followed by t-test statistics to locate a seed in the salience network. Then, we implemented a seed-based connectivity analysis to gather cluster-level inferences contrasting our subject groups. We show evidence supporting our hypothesis that the AMI surgery induces functional network reorganization resulting in a neural configuration that significantly differs from the neural configuration after TA surgery. AMI subjects show significantly less coupling with regions functionally dedicated to selecting where to focus attention when it comes to salient stimuli. Our findings provide researchers and clinicians with a critical mechanistic understanding of the effect of AMI amputation on brain networks at rest, which has promising implications for improved neurorehabilitation and prosthetic control.

Identifiants

DOI: 10.1038/s41598-024-63134-4 PMID: 38862558
pubmed: 38862558
doi: 10.1038/s41598-024-63134-4
pii: 10.1038/s41598-024-63134-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

13456

Subventions

Organisme : Center for Functional Neuroimaging Technologies
ID : P41EB015896
Organisme : Center for Mesoscale Mapping
ID : P41EB030006
Organisme : NIH HHS
ID : R00EB016689
Pays : United States

Informations de copyright

© 2024. The Author(s).

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Auteurs

Laura A Chicos (LA)

Biomechatronics Group, Massachusetts Institute of Technology, Media Lab, Cambridge, MA, 02139, USA. laurachi@media.mit.edu.
K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. laurachi@media.mit.edu.

D Rangaprakash (D)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Department of Radiology, Harvard Medical School, Boston, MA, 02115, USA.

Shriya S Srinivasan (SS)

Harvard-MA Institute of Technology Division of Health Sciences and Technology, Cambridge, MA, 02139, USA.
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Allston, MA, 02134, USA.

Samantha Gutierrez-Arango (S)

Biomechatronics Group, Massachusetts Institute of Technology, Media Lab, Cambridge, MA, 02139, USA.
K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Hyungeun Song (H)

Biomechatronics Group, Massachusetts Institute of Technology, Media Lab, Cambridge, MA, 02139, USA.
K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Harvard-MA Institute of Technology Division of Health Sciences and Technology, Cambridge, MA, 02139, USA.

Robert L Barry (RL)

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Department of Radiology, Harvard Medical School, Boston, MA, 02115, USA.
Harvard-MA Institute of Technology Division of Health Sciences and Technology, Cambridge, MA, 02139, USA.

Hugh M Herr (HM)

Biomechatronics Group, Massachusetts Institute of Technology, Media Lab, Cambridge, MA, 02139, USA.
K. Lisa Yang Center for Bionics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures orthopédiques › Amputation chirurgicale › Resting state neurophysiology of...
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