Shifts in structural connectome organization in the limbic and sensory systems of patients with episodic migraine.
Episodic migraine
Limbic system
Manifold eccentricity
Structural connectivity
Tractography
Journal
The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562
Informations de publication
Date de publication:
11 Jun 2024
11 Jun 2024
Historique:
received:
29
03
2024
accepted:
06
06
2024
medline:
12
6
2024
pubmed:
12
6
2024
entrez:
11
6
2024
Statut:
epublish
Résumé
Migraine is a complex neurological condition characterized by recurrent headaches, which is often accompanied by various neurological symptoms. Magnetic resonance imaging (MRI) is a powerful tool for investigating whole-brain connectivity patterns; however, systematic assessment of structural connectome organization has rarely been performed. In the present study, we aimed to examine the changes in structural connectivity in patients with episodic migraines using diffusion MRI. First, we computed structural connectivity using diffusion MRI tractography, after which we applied dimensionality reduction techniques to the structural connectivity and generated three low-dimensional eigenvectors. We subsequently calculated the manifold eccentricity, defined as the Euclidean distance between each data point and the center of the data in the manifold space. We then compared the manifold eccentricity between patients with migraines and healthy controls, revealing significant between-group differences in the orbitofrontal cortex, temporal pole, and sensory/motor regions. Between-group differences in subcortico-cortical connectivity further revealed significant changes in the amygdala, accumbens, and caudate nuclei. Finally, supervised machine learning effectively classified patients with migraines and healthy controls using cortical and subcortical structural connectivity features, highlighting the importance of the orbitofrontal and sensory cortices, in addition to the caudate, in distinguishing between the groups. Our findings confirmed that episodic migraine is related to the structural connectome changes in the limbic and sensory systems, suggesting its potential utility as a diagnostic marker for migraine.
Identifiants
pubmed: 38862883
doi: 10.1186/s10194-024-01806-2
pii: 10.1186/s10194-024-01806-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
99Subventions
Organisme : National Research Foundation of Korea
ID : NRF2020R1A2B5B01001826
Organisme : National Research Foundation of Korea
ID : NRF2022R1A5A7033499
Organisme : Korea Medical Device Development Fund
ID : Project number: RS-2023-00229484
Organisme : Institute for Information and Communications Technology Promotion
ID : No. 2022-0-00448, Deep Total Recall: Continuous Learning for Human-Like Recall of Artificial Neural Networks
Organisme : Institute for Basic Science
ID : IBS-R015-D1
Informations de copyright
© 2024. The Author(s).
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