Distribution of Inflammatory Infiltrate in Feline Mammary Lesions: Relationship With Clinicopathological Features.

feline mammary tumours inflammation mammary gland microenvironment tertiary lymphoid structures

Journal

Veterinary and comparative oncology
ISSN: 1476-5829
Titre abrégé: Vet Comp Oncol
Pays: England
ID NLM: 101185242

Informations de publication

Date de publication:
11 Jun 2024
Historique:
revised: 25 03 2024
received: 30 01 2024
accepted: 21 05 2024
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 12 6 2024
Statut: aheadofprint

Résumé

Inflammation is a frequent finding in feline mammary neoplasms. Recent research suggests that the presence and location of tumour-associated immune cells might play a significant role in the clinical outcome of feline mammary carcinomas. The present study aimed to characterise the overall inflammatory infiltrates in healthy, hyperplastic/dysplastic, benign and malignant lesions of the feline mammary gland, and to evaluate its association with clinicopathological features. Perilesional and intralesional inflammatory foci were evaluated in 307 lesions from 185 queens, and categorised according to its distribution and intensity. The presence, location and density of tertiary lymphoid structures were also assessed. A control group included 24 queens without mammary changes. The presence of intralesional and perilesional inflammatory infiltrate was observed in a majority of the lesions (80.8% and 90.2%, respectively), but differed according to the type of mammary lesion, being more remarkable in malignant neoplasms. Only scarce individual cells were observed in 28.1% of the normal mammary glands. Data analysis revealed statistically significant associations (p < 0.05) between the presence of a more prominent intralesional and perilesional inflammatory reaction and several clinicopathological features associated with worse prognosis, including clinical stage, tumour size, mitotic count, lymphovascular invasion and lymph node metastasis. Furthermore, tertiary lymphoid structures were significantly more frequent in tumours with an infiltrative growth and lymph node metastasis. According to our results, the inflammatory reaction present in different types of feline mammary lesions is associated with the development of more aggressive tumours.

Identifiants

pubmed: 38863270
doi: 10.1111/vco.12987
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Fundação para a Ciência e a Tecnologia (FCT)
ID : 2022.09644.BD
Organisme : Fundação para a Ciência e a Tecnologia (FCT)
ID : UIDB/00772/2020

Informations de copyright

© 2024 John Wiley & Sons Ltd.

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Auteurs

Joana Rodrigues-Jesus (J)

Department of Pathology and Molecular Immunology, School of Medicine and Biomedical Sciences, ICBAS-UP, University of Porto, Porto, Portugal.

Ana Canadas-Sousa (A)

Department of Pathology and Molecular Immunology, School of Medicine and Biomedical Sciences, ICBAS-UP, University of Porto, Porto, Portugal.

Pedro Oliveira (P)

Department of Populations Studies, School of Medicine and Biomedical Sciences, ICBAS-UP, University of Porto, Porto, Portugal.

Ana Catarina Figueira (AC)

OneVet Veterinary University Hospital of Coimbra (HVUC), Coimbra, Portugal.
Centre for Investigation Vasco da Gama (CIVG), Department of Veterinary Sciences, Vasco da Gama University School, Coimbra, Portugal.

Carla Marrinhas (C)

Centre for Investigation Vasco da Gama (CIVG), Department of Veterinary Sciences, Vasco da Gama University School, Coimbra, Portugal.
OneVet Veterinary Hospital of Baixo Vouga (HVBV), Águeda, Portugal.

Gonçalo N Petrucci (GN)

Centre for Investigation Vasco da Gama (CIVG), Department of Veterinary Sciences, Vasco da Gama University School, Coimbra, Portugal.
OneVet Veterinary Hospital of Porto (HVP), Porto, Portugal.
Department of Animal and Veterinary Sciences, University Institute for Health Sciences, CESPU, CRL, Gandra, Portugal.

Hugo Gregório (H)

Department of Animal and Veterinary Sciences, University Institute for Health Sciences, CESPU, CRL, Gandra, Portugal.
AniCura Veterinary Hospital Centre (CHV), Porto, Portugal.

Flora Tinoco (F)

Dra. Flora Tinoco Veterinary Clinic, Maia, Portugal.

Andrea Goulart (A)

Oeste Veterinary Centre, Leiria, Portugal.

Helena Felga (H)

Clínica dos Gatos Veterinary Clinic, Porto, Portugal.

Hugo Vilhena (H)

OneVet Veterinary University Hospital of Coimbra (HVUC), Coimbra, Portugal.
Centre for Investigation Vasco da Gama (CIVG), Department of Veterinary Sciences, Vasco da Gama University School, Coimbra, Portugal.
Animal and Veterinary Research Centre (CECAV), University of Trás-os-Montes e Alto Douro, Vila Real, Portugal.
Associate Laboratory of Animal and Veterinary Sciences AL4AnimaLS, Lisbon, Portugal.

Patrícia Dias-Pereira (P)

Department of Pathology and Molecular Immunology, School of Medicine and Biomedical Sciences, ICBAS-UP, University of Porto, Porto, Portugal.

Classifications MeSH