A risk estimation method for depression based on the dysbiosis of intestinal microbiota in Japanese patients.

Early detection of depression is important for preventing depression-related suicides and reducing the risk of recurrence. This study explored the association between depression and intestinal microbiota and developed a depression risk-estimation method based on this. The intestinal microbiota of Japanese patients with depression (33 males and 35 females) and disease-free controls (246 males and 384 females) in their 20's to 60's were compared by sex using 16S rRNA gene amplicon sequencing. A depression-risk estimation method was developed using structural equation modeling. Intestinal bacteria taxa that differed between depression and control groups were identified based on effect size (absolute value greater than 0.2). This study provides insights into depression etiology and aids in its early detection and treatment.

Informations de copyright

Copyright © 2024 Okuma, Hatayama, Tokuno, Ebara, Odachi, Masuyama, Hoshiko and Tanaka.

Déclaration de conflit d'intérêts

HM is the President of Symbiosis Solutions Inc. Tokyo, Japan. KO, KH, HT, AE, and AO are employees of Symbiosis Solutions Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from Japan Tobacco Inc. The funder had the following involvement in the study: study design.