A visual circuit related to the parabrachial nucleus for the antipruritic effects of bright light treatment.

CP: Neuroscience itch light treatment parabrachial nucleus visual thamalus

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
11 Jun 2024
Historique:
received: 08 01 2024
revised: 11 05 2024
accepted: 29 05 2024
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 12 6 2024
Statut: aheadofprint

Résumé

In addition to its role in vision, light also serves non-image-forming visual functions. Despite clinical evidence suggesting the antipruritic effects of bright light treatment, the circuit mechanisms underlying the effects of light on itch-related behaviors remain poorly understood. In this study, we demonstrate that bright light treatment reduces itch-related behaviors in mice through a visual circuit related to the lateral parabrachial nucleus (LPBN). Specifically, a subset of retinal ganglion cells (RGCs) innervates GABAergic neurons in the ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL), which subsequently inhibit CaMKIIα

Identifiants

DOI: 10.1016/j.celrep.2024.114356 PMID: 38865246
pubmed: 38865246
pii: S2211-1247(24)00684-3
doi: 10.1016/j.celrep.2024.114356
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114356

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Zhengfang Hu (Z)

Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.

Xiaodan Huang (X)

Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.

Jianyu Liu (J)

Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.

Ziyang Wang (Z)

Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.

Yue Xi (Y)

Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, China.

Yan Yang (Y)

Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.

Song Lin (S)

Physiology Department, School of Medicine, Jinan University, Guangzhou 510632, China.

Kwok-Fai So (KF)

Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China; Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China; Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou 510515, China; Key Laboratory of Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Lu Huang (L)

Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China. Electronic address: huanglu@jnu.edu.cn.

Qian Tao (Q)

Department of Rehabilitation Medicine, First Affiliated Hospital of Jinan University, Department of Public Health and Preventive Medicine Psychology, School of Medicine, Jinan University, Guangzhou 510632, China. Electronic address: taoqian16@jnu.edu.cn.

Chaoran Ren (C)

Department of Neurology and Stroke Center, First Affiliated Hospital of Jinan University, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China; Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China; Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou 510515, China. Electronic address: tchaoran@jnu.edu.cn.

Classifications MeSH