Long-Term Depressive Symptom Trajectories and Midlife Cognition: The CARDIA Study.

Humans Female Male Depression / epidemiology Adult White People Middle Aged Cognition / physiology Neuropsychological Tests Prospective Studies Black or African American Young Adult Longitudinal Studies Cognitive Dysfunction / etiology

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
Jul 2024
Historique:
medline: 12 6 2024
pubmed: 12 6 2024
entrez: 12 6 2024
Statut: ppublish

Résumé

The nature of associations between depressive symptoms and cognition early in the life course remains unclear, and racial differences in these associations are not well characterized. The aim of this study was to examine the relationship between trajectories of depressive symptom over 20 years, beginning in young adulthood, and cognitive functions in middle-age among Black and White adults. We used prospective data from participants of the Coronary Artery Risk Development in Young Adults Study. Depressive symptoms were measured at 5 study visits between 1990 and 2010 using the Center for Epidemiologic Studies Depression scale. We used latent class group-based modeling to identify 4 trajectories: "persistently low," "persistently medium," "medium decreasing," and "high increasing" depressive symptoms. In 2015, cognitive function was measured using the Digit Symbol Substitution Test (DSST), Stroop test (reverse coded), and Rey Auditory-Verbal Learning Test (RAVLT).We excluded participants who missed the cognitive battery or had no depressive symptoms measurements, resulting in a total of 3,117 participants. All cognitive tests were standardized, and linear regression was used to relate depressive trajectories with 2015 cognitive functions. The mean [SD] baseline age was 30.1 [3.6] years, and 57% were female. The associations between depressive symptoms and cognition significantly differed by race ( Prolonged exposure to elevated depressive symptoms beginning in young adulthood may result in worse cognitive function over midlife. This association was stronger among Black adults.

Sections du résumé

BACKGROUND AND OBJECTIVES OBJECTIVE
The nature of associations between depressive symptoms and cognition early in the life course remains unclear, and racial differences in these associations are not well characterized. The aim of this study was to examine the relationship between trajectories of depressive symptom over 20 years, beginning in young adulthood, and cognitive functions in middle-age among Black and White adults.
METHODS METHODS
We used prospective data from participants of the Coronary Artery Risk Development in Young Adults Study. Depressive symptoms were measured at 5 study visits between 1990 and 2010 using the Center for Epidemiologic Studies Depression scale. We used latent class group-based modeling to identify 4 trajectories: "persistently low," "persistently medium," "medium decreasing," and "high increasing" depressive symptoms. In 2015, cognitive function was measured using the Digit Symbol Substitution Test (DSST), Stroop test (reverse coded), and Rey Auditory-Verbal Learning Test (RAVLT).We excluded participants who missed the cognitive battery or had no depressive symptoms measurements, resulting in a total of 3,117 participants. All cognitive tests were standardized, and linear regression was used to relate depressive trajectories with 2015 cognitive functions.
RESULTS RESULTS
The mean [SD] baseline age was 30.1 [3.6] years, and 57% were female. The associations between depressive symptoms and cognition significantly differed by race (
DISCUSSION CONCLUSIONS
Prolonged exposure to elevated depressive symptoms beginning in young adulthood may result in worse cognitive function over midlife. This association was stronger among Black adults.

Identifiants

DOI: 10.1212/WNL.0000000000209510 PMID: 38865677
pubmed: 38865677
doi: 10.1212/WNL.0000000000209510
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e209510

Auteurs

Leslie Grasset (L)

From the Univ. Bordeaux (L.G.), Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219; Inserm, CIC1401-EC, Bordeaux, France; Department of Epidemiology (A.Z.A.H., F.M., P.L.), Mailman School of Public Health, Columbia University, NY; Division of Medicine (T.E.), Miller School of Medicine, University of Miami, FL; Clinical Research Institute (M.E.), Department of Internal Medicine, American University of Beirut, Lebanon; and Departments of Psychiatry (E.V., K.Y.), Neurology, and Epidemiology and Biostatistics, University of California, San Francisco.
ORCID: 0000-0003-2812-0103

Adina Zeki Al Hazzouri (A)

From the Univ. Bordeaux (L.G.), Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219; Inserm, CIC1401-EC, Bordeaux, France; Department of Epidemiology (A.Z.A.H., F.M., P.L.), Mailman School of Public Health, Columbia University, NY; Division of Medicine (T.E.), Miller School of Medicine, University of Miami, FL; Clinical Research Institute (M.E.), Department of Internal Medicine, American University of Beirut, Lebanon; and Departments of Psychiatry (E.V., K.Y.), Neurology, and Epidemiology and Biostatistics, University of California, San Francisco.

Floriana Milazzo (F)

From the Univ. Bordeaux (L.G.), Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219; Inserm, CIC1401-EC, Bordeaux, France; Department of Epidemiology (A.Z.A.H., F.M., P.L.), Mailman School of Public Health, Columbia University, NY; Division of Medicine (T.E.), Miller School of Medicine, University of Miami, FL; Clinical Research Institute (M.E.), Department of Internal Medicine, American University of Beirut, Lebanon; and Departments of Psychiatry (E.V., K.Y.), Neurology, and Epidemiology and Biostatistics, University of California, San Francisco.

Peiyi Lu (P)

From the Univ. Bordeaux (L.G.), Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219; Inserm, CIC1401-EC, Bordeaux, France; Department of Epidemiology (A.Z.A.H., F.M., P.L.), Mailman School of Public Health, Columbia University, NY; Division of Medicine (T.E.), Miller School of Medicine, University of Miami, FL; Clinical Research Institute (M.E.), Department of Internal Medicine, American University of Beirut, Lebanon; and Departments of Psychiatry (E.V., K.Y.), Neurology, and Epidemiology and Biostatistics, University of California, San Francisco.

Tali Elfassy (T)

From the Univ. Bordeaux (L.G.), Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219; Inserm, CIC1401-EC, Bordeaux, France; Department of Epidemiology (A.Z.A.H., F.M., P.L.), Mailman School of Public Health, Columbia University, NY; Division of Medicine (T.E.), Miller School of Medicine, University of Miami, FL; Clinical Research Institute (M.E.), Department of Internal Medicine, American University of Beirut, Lebanon; and Departments of Psychiatry (E.V., K.Y.), Neurology, and Epidemiology and Biostatistics, University of California, San Francisco.
ORCID: 0000-0002-7528-7988

Martine Elbejjani (M)

From the Univ. Bordeaux (L.G.), Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219; Inserm, CIC1401-EC, Bordeaux, France; Department of Epidemiology (A.Z.A.H., F.M., P.L.), Mailman School of Public Health, Columbia University, NY; Division of Medicine (T.E.), Miller School of Medicine, University of Miami, FL; Clinical Research Institute (M.E.), Department of Internal Medicine, American University of Beirut, Lebanon; and Departments of Psychiatry (E.V., K.Y.), Neurology, and Epidemiology and Biostatistics, University of California, San Francisco.

Eric Vittinghoff (E)

From the Univ. Bordeaux (L.G.), Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219; Inserm, CIC1401-EC, Bordeaux, France; Department of Epidemiology (A.Z.A.H., F.M., P.L.), Mailman School of Public Health, Columbia University, NY; Division of Medicine (T.E.), Miller School of Medicine, University of Miami, FL; Clinical Research Institute (M.E.), Department of Internal Medicine, American University of Beirut, Lebanon; and Departments of Psychiatry (E.V., K.Y.), Neurology, and Epidemiology and Biostatistics, University of California, San Francisco.

Kristine Yaffe (K)

From the Univ. Bordeaux (L.G.), Inserm, Bordeaux Population Health Research Center, Team VINTAGE, UMR 1219; Inserm, CIC1401-EC, Bordeaux, France; Department of Epidemiology (A.Z.A.H., F.M., P.L.), Mailman School of Public Health, Columbia University, NY; Division of Medicine (T.E.), Miller School of Medicine, University of Miami, FL; Clinical Research Institute (M.E.), Department of Internal Medicine, American University of Beirut, Lebanon; and Departments of Psychiatry (E.V., K.Y.), Neurology, and Epidemiology and Biostatistics, University of California, San Francisco.
ORCID: 0000-0003-0919-3825

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Personnes › Blancs › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Personnes › Nord-Américains › Groupes de population aux États-Unis › Populations d'origine continentale › Noir ou Africain Américain › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Long-Term Depressive Symptom Trajectories and...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Long-Term Depressive Symptom Trajectories and...