Real-world data on tezepelumab in patients with severe asthma in Germany.
Tezepelumab
antibody
biologic
real-world
severe asthma
switching
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
10 Jun 2024
10 Jun 2024
Historique:
received:
09
04
2024
revised:
21
05
2024
accepted:
31
05
2024
medline:
13
6
2024
pubmed:
13
6
2024
entrez:
12
6
2024
Statut:
aheadofprint
Résumé
Tezepelumab is a novel biologic blocking thymic stromal lymphopoetin (TSLP), approved for severe asthma irrespective of biomarker levels or phenotype. To characterize a real-world tezepelumab patient cohort and the efficacy among various asthma phenotypes. We performed a retrospective, multi-center study on patients with severe asthma initiating tezepelumab. Clinical response was evaluated at 3 and 6 months. We included 129 patients with an average age of 52.5 ± 13.1 years, 59.7% were female. The majority (86.0%) had increased T2 biomarkers, 68.2% an allergic and 31.8% an eosinophilic phenotype. 23.3% of patients were biologic-naïve. 22 (18.2%) patients discontinued tezepelumab therapy due to suspected side-effects or insufficient efficacy. At 6 months follow-up, median reduction in annualized exacerbation rate (AE) was -1 [-2.9;0.0], the reduction of oral corticosteroid (OCS) dose among patients with long term OCS therapy was -5 mg [-10;0] and asthma control test (ACT) improved by 2 [0;5] points. 80.8% demonstrated a treatment response according to Biologic Asthma Response Score. There were no significant differences in treatment response between T2-high vs. T2 low, early vs. adult onset and eosinophilic vs. non-eosinophilic asthma. Prior treatment with other biologics was associated with inferior treatment response. In this real-life cohort, including a large proportion of patients with history of previous biologic use and encompassing various subgroups, the majority responded to tezepelumab. Our data further suggest a steroid-sparing effect of tezepelumab.
Sections du résumé
BACKGROUND
BACKGROUND
Tezepelumab is a novel biologic blocking thymic stromal lymphopoetin (TSLP), approved for severe asthma irrespective of biomarker levels or phenotype.
OBJECTIVE
OBJECTIVE
To characterize a real-world tezepelumab patient cohort and the efficacy among various asthma phenotypes.
METHODS
METHODS
We performed a retrospective, multi-center study on patients with severe asthma initiating tezepelumab. Clinical response was evaluated at 3 and 6 months.
RESULTS
RESULTS
We included 129 patients with an average age of 52.5 ± 13.1 years, 59.7% were female. The majority (86.0%) had increased T2 biomarkers, 68.2% an allergic and 31.8% an eosinophilic phenotype. 23.3% of patients were biologic-naïve. 22 (18.2%) patients discontinued tezepelumab therapy due to suspected side-effects or insufficient efficacy. At 6 months follow-up, median reduction in annualized exacerbation rate (AE) was -1 [-2.9;0.0], the reduction of oral corticosteroid (OCS) dose among patients with long term OCS therapy was -5 mg [-10;0] and asthma control test (ACT) improved by 2 [0;5] points. 80.8% demonstrated a treatment response according to Biologic Asthma Response Score. There were no significant differences in treatment response between T2-high vs. T2 low, early vs. adult onset and eosinophilic vs. non-eosinophilic asthma. Prior treatment with other biologics was associated with inferior treatment response.
CONCLUSION
CONCLUSIONS
In this real-life cohort, including a large proportion of patients with history of previous biologic use and encompassing various subgroups, the majority responded to tezepelumab. Our data further suggest a steroid-sparing effect of tezepelumab.
Identifiants
pubmed: 38866104
pii: S2213-2198(24)00625-1
doi: 10.1016/j.jaip.2024.05.052
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024. Published by Elsevier Inc.