Traditional Korean diet high in one-carbon nutrients increases global DNA methylation: implication for epigenetic diet.

DNA methylation Epigenetics One-carbon metabolism Traditional Korean diet

Journal

European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704

Informations de publication

Date de publication:
12 Jun 2024
Historique:
received: 06 08 2023
accepted: 30 05 2024
medline: 13 6 2024
pubmed: 13 6 2024
entrez: 12 6 2024
Statut: aheadofprint

Résumé

DNA methylation is a major epigenetic phenomenon through which diet affects health and disease. This study aimed to determine the epigenetic influence of the traditional Korean diet (K-diet) on global DNA methylation via one-carbon metabolism. A crossover study was conducted on 52 women. Two diets, a K-diet, high in plant foods and low in calories and animal fat, and a control diet, similar to the diet currently consumed in Korea, were provided to all subjects alternately for 4 weeks with a 4-week washout period. Clinical parameters were measured before and after each dietary intervention. Nutrient intake was calculated by using a computer-aided nutritional analysis program. One-carbon metabolites in the serum and global DNA methylation in peripheral mononuclear cells were determined using ultra-performance liquid chromatography-tandem mass spectrometry. The K-diet group consumed more folate (669.9 ± 6.7 µg vs. 502.7 ± 3.0, p < 0.001), B6, B12, serine, and choline, and less methionine (992.6 ± 63 vs. 1048.3 mg ± 34.1, p < 0.0001) than the control group did. In the K-diet group, the increment of plasma 5-methyltetrahydrofolate (0.08 µg/mL ± 0.11 vs 0.02 ± 0.10, p < 0.009) and decrement of L-homocysteine (- 70.7 ± 85.0 vs - 39.3 ± 69.4, p < 0.0168) were greater than those of the control group. Global DNA methylation was significantly increased in the K-diet group (6.70 ± 3.02% to 9.45 ± 3.69, p < 0.0001) but not in the control group. A K-diet high in one-carbon nutrients can enhance the global DNA methylation status, suggesting an epigenetic mechanism by which the K-diet conveys health effects. Trial registration Korean Clinical Trial Registry (trial number: KCT0005340, 24/08/2020, retrospectively registered).

Identifiants

DOI: 10.1007/s00394-024-03442-7 PMID: 38867083
pubmed: 38867083
doi: 10.1007/s00394-024-03442-7
pii: 10.1007/s00394-024-03442-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Ministry of Science and ICT, South Korea
ID : E0150302-06
Organisme : Ministry of Science and ICT, South Korea
ID : E0220602-04

Informations de copyright

© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Sukyung Chun (S)

Department of Gastroenterology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, 13496, South Korea.
ORCID: 0000-0001-8331-8521

Min Jung Kim (MJ)

Research Group of Personalized Diet, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, 55365, South Korea.
ORCID: 0000-0002-8894-8538

Phil-Kyung Shin (PK)

CHA Bio Complex, CHA University, Seongnam, 13488, South Korea.

Seon-Joo Park (SJ)

Department of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam, 13120, South Korea.
Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam, 13120, South Korea.

Hye Jeong Yang (HJ)

Research Group of Personalized Diet, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, 55365, South Korea.

Jin Hee Kim (JH)

Research Group of Personalized Diet, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, 55365, South Korea.

Kyun-Hee Lee (KH)

Research Group of Personalized Diet, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, 55365, South Korea.
Department of Food Biotechnology, Korea University of Science and Technology, Wanju, 55365, South Korea.

Moonju Hong (M)

Research Group of Personalized Diet, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, 55365, South Korea.
Department of Food Biotechnology, Korea University of Science and Technology, Wanju, 55365, South Korea.

Dae Young Kwon (DY)

Department of Food and Nutrition, Hoseo University, Asan, 31499, South Korea.

Simonetta Friso (S)

Unit of Internal Medicine B and 'Epigenomics and Gene-Nutrient Interactions' Laboratory, Department of Medicine, University of Verona School of Medicine, Policlinico "G.B. Rossi," P. le L.A. Scuro 10, 37134, Verona, Italy.

Hae-Jeung Lee (HJ)

Department of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam, 13120, South Korea.
Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam, 13120, South Korea.
Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, South Korea.

Myung-Sunny Kim (MS)

Research Group of Personalized Diet, Korea Food Research Institute, 245 Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do, 55365, South Korea. truka@kfri.re.kr.
Department of Food Biotechnology, Korea University of Science and Technology, Wanju, 55365, South Korea. truka@kfri.re.kr.
ORCID: 0000-0002-5020-3397

Sang-Woon Choi (SW)

Chaum Life Center, CHA University School of Medicine, 442 Dosan-daero, Gangnam-gu, Seoul, 06062, South Korea. sangwoon.choi@gmail.com.
Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, 01003, USA. sangwoon.choi@gmail.com.
ORCID: 0000-0003-0713-379X

Classifications MeSH