The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy.

Journal

Research (Washington, D.C.)
ISSN: 2639-5274
Titre abrégé: Research (Wash D C)
Pays: United States
ID NLM: 101747148

Informations de publication

Date de publication:
2024
Historique:
received: 10 12 2023
accepted: 18 03 2024
medline: 13 6 2024
pubmed: 13 6 2024
entrez: 13 6 2024
Statut: epublish

Résumé

The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions. Although tumor metabolic reprogramming places aerobic glycolysis in a dominant position, the TCA cycle remains indispensable for tumor cells as a hub for the metabolic linkage and interconversion of glucose, lipids, and certain amino acids. TCA intermediates such as citrate, α-ketoglutarate, succinate, and fumarate are altered in tumors, and they regulate the tumor metabolism, signal transduction, and immune environment to affect tumorigenesis and tumor progression. This article provides a comprehensive review of the modifications occurring in tumor cells in relation to the intermediates of the TCA cycle, which affects tumor pathogenesis and current therapeutic strategy for therapy through targeting TCA cycle in cancer cells.

Identifiants

DOI: 10.34133/research.0351 PMID: 38867720 PMC: PMC11168306
pubmed: 38867720
doi: 10.34133/research.0351
pii: 0351
pmc: PMC11168306
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

0351

Informations de copyright

Copyright © 2024 Jie Wu et al.

Déclaration de conflit d'intérêts

Competing interests: The authors declare that they have no competing interests.

Auteurs

Jie Wu (J)

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Furong Labratory, Changsha, Hunan, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Nian Liu (N)

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Furong Labratory, Changsha, Hunan, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Jing Chen (J)

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Furong Labratory, Changsha, Hunan, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Qian Tao (Q)

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Furong Labratory, Changsha, Hunan, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Qiuqiu Li (Q)

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Furong Labratory, Changsha, Hunan, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Jie Li (J)

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Furong Labratory, Changsha, Hunan, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Xiang Chen (X)

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Furong Labratory, Changsha, Hunan, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Cong Peng (C)

The Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Furong Labratory, Changsha, Hunan, China.
Hunan Key Laboratory of Skin Cancer and Psoriasis, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China.
ORCID: 0000-0001-7104-5490

Classifications MeSH