Insight into Cardioprotective Effects and Mechanisms of Dexmedetomidine.

Cardioprotective Cell death Dexmedetomidine Myocardial ischemia-reperfusion injury α2 adrenoreceptor agonist

Journal

Cardiovascular drugs and therapy
ISSN: 1573-7241
Titre abrégé: Cardiovasc Drugs Ther
Pays: United States
ID NLM: 8712220

Informations de publication

Date de publication:
13 Jun 2024
Historique:
accepted: 17 05 2024
medline: 13 6 2024
pubmed: 13 6 2024
entrez: 13 6 2024
Statut: aheadofprint

Résumé

Cardiovascular disease remains the leading cause of death worldwide. Dexmedetomidine is a highly selective α2 adrenergic receptor agonist with sedative, analgesic, anxiolytic, and sympatholytic properties, and several studies have shown its possible protective effects in cardiac injury. The aim of this review is to further elucidate the underlying cardioprotective mechanisms of dexmedetomidine, thus suggesting its potential in the clinical management of cardiac injury. Our review summarizes the findings related to the involvement of dexmedetomidine in cardiac injury and discusses the results in the light of different mechanisms. We found that numerous mechanisms may contribute to the cardioprotective effects of dexmedetomidine, including the regulation of programmed cell death, autophagy and fibrosis, alleviation of inflammatory response, endothelial dysfunction and microcirculatory derangements, improvement of mitochondrial dysregulation, hemodynamics, and arrhythmias. Dexmedetomidine may play a promising and beneficial role in the treatment of cardiovascular disease.

Identifiants

pubmed: 38869744
doi: 10.1007/s10557-024-07579-9
pii: 10.1007/s10557-024-07579-9
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : the National Natural Science Foundation of China
ID : 82060060
Organisme : Joint Special Key Fund of Applied Fundamental Research of Kunming Medical University granted by Science and Technology Office of Yunnan
ID : 202201AY070001-040
Organisme : Yunnan Health Training Project of High Levels Talents
ID : L-2018007
Organisme : Yunnan Provincial Ten Thousand-Talent Program-Famous Doctor
ID : YNWR-MY-2018-043

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Leyu Jiang (L)

Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Wei Xiong (W)

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.

Yuqiao Yang (Y)

Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Jinqiao Qian (J)

Department of Anesthesiology, First Affiliated Hospital of Kunming Medical University, Kunming, China. qianjinqiao@126.com.

Classifications MeSH