Electrocontractile remodeling of isolated cardiomyocytes induced during early-stage hypercholesterolemia.
Arrhythmias
Cardiomyocyte
Cholesterol
Electrophysiology
Hypercholesterolemia
Journal
Journal of bioenergetics and biomembranes
ISSN: 1573-6881
Titre abrégé: J Bioenerg Biomembr
Pays: United States
ID NLM: 7701859
Informations de publication
Date de publication:
13 Jun 2024
13 Jun 2024
Historique:
received:
28
06
2023
accepted:
27
05
2024
medline:
13
6
2024
pubmed:
13
6
2024
entrez:
13
6
2024
Statut:
aheadofprint
Résumé
Hypercholesterolemia is one of the most important risk factors for cardiovascular diseases. However, it is mostly associated with vascular dysfunction and atherosclerotic lesions, while evidence of direct effects of hypercholesterolemia on cardiomyocytes and heart function is still incomplete and controversial. In this study, we assessed the direct effects of hypercholesterolemia on heart function and the electro-contractile properties of isolated cardiomyocytes. After 5 weeks, male Swiss mice fed with AIN-93 diet added with 1.25% cholesterol (CHO), developed an increase in total serum cholesterol levels and cardiomyocytes cholesterol content. These changes led to altered electrocardiographic records, with a shortening of the QT interval. Isolated cardiomyocytes displayed a shortening of the action potential duration with increased rate of depolarization, which was explained by increased I
Identifiants
pubmed: 38869808
doi: 10.1007/s10863-024-10026-x
pii: 10.1007/s10863-024-10026-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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