Profound Sexual Dysfunction Among Patients with Hidradenitis Suppurativa: A Cross-sectional Study.

Erectile dysfunction Hidradenitis suppurativa Sexual dysfunction Sexuality

Journal

Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450

Informations de publication

Date de publication:
13 Jun 2024
Historique:
received: 05 05 2024
accepted: 24 05 2024
medline: 13 6 2024
pubmed: 13 6 2024
entrez: 13 6 2024
Statut: aheadofprint

Résumé

Sexual health, a critical aspect of overall well-being, is often compromised in individuals with chronic disorders. Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that mainly affects intertriginous areas, potentially impacting sexual health as a result of its specific symptoms and psychosocial burden. This cross-sectional study utilized data from the EpiCAi project, focusing on 199 patients with HS. Participants completed digital questionnaires assessing sexual health via sex-specific instruments: the Female Sexual Function Index (FSFI) for women and the International Index of Erectile Function (IIEF) for men, alongside different psychosocial scales. The disease severity was assessed using the Hurley stage and the Lesion Identification Scheme for Acne Inversa (LISAI). The majority of the participants reported impaired sexual health, with significant clinical sexual dysfunctions noted in 71.8% of women (FSFI score < 26) and erectile dysfunction in 63.8% of men. Sexual dysfunction was associated with several factors, including age, and marital status. Psychosocial factors, notably depression and quality of life, showed strong correlations with sexual health outcomes. Notably, women over 40 and those treated with biologics reported more severe dysfunction, while among men, employment status significantly influenced sexual health. HS profoundly affects the sexual health of both male and female patients, with significant impacts on their quality of life and psychological well-being. The findings underscore the necessity for healthcare providers to address sexual health proactively in the management of HS, considering both physical symptoms and psychosocial impacts. This holistic approach is essential for improving patient outcomes and overall quality of life. German Register for Clinical Trials, identifier DRKS00025315.

Identifiants

DOI: 10.1007/s13555-024-01196-y PMID: 38869824
pubmed: 38869824
doi: 10.1007/s13555-024-01196-y
pii: 10.1007/s13555-024-01196-y
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : ERA PerMed
ID : Biomolecular Analyses for Tailored Medicine in AcneiNversa (BATMAN) project

Informations de copyright

© 2024. The Author(s).

Références

WHO. Sexual health 2024. https://www.who.int/health-topics/sexual-health#tab=tab_1 . Accessed 18 Mar 2024.
Verschuren JE, Enzlin P, Dijkstra PU, Geertzen JH, Dekker R. Chronic disease and sexuality: a generic conceptual framework. J Sex Res. 2010;47(2):153–70.
pubmed: 20358458 doi: 10.1080/00224491003658227
Anderson RM. Positive sexuality and its impact on overall well-being. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2013;56(2):208–14.
pubmed: 23361205 doi: 10.1007/s00103-012-1607-z
Molina-Leyva A, Jiménez-Moleón JJ, Naranjo-Sintes R, Ruiz-Carrascosa JC. Sexual dysfunction in psoriasis: a systematic review. J Eur Acad Dermatol Venereol. 2015;29(4):649–55.
pubmed: 25424331 doi: 10.1111/jdv.12845
Wojciechowska-Zdrojowy M, Reid A, Szepietowski JC, Wojciechowski A. Analysis of sexual problems in men with psoriasis. J Sex Marital Ther. 2018;44(8):737–45.
pubmed: 29648989 doi: 10.1080/0092623X.2018.1462276
Sukan M, Maner F. The problems in sexual functions of vitiligo and chronic urticaria patients. J Sex Marital Ther. 2007;33(1):55–64.
pubmed: 17162488 doi: 10.1080/00926230600998482
Egeberg A, Hansen PR, Gislason GH, Skov L, Thyssen JP. Erectile dysfunction in male adults with atopic dermatitis and psoriasis. J Sex Med. 2017;14(3):380–6.
pubmed: 28109691 doi: 10.1016/j.jsxm.2016.12.233
Linares-Gonzalez L, Lozano-Lozano I, Gutierrez-Rojas L, Lozano-Lozano M, Rodenas-Herranz T, Ruiz-Villaverde R. Sexual dysfunction and atopic dermatitis: a systematic review. Life (Basel). 2021;11(12):1314.
pubmed: 34947845
Li SJ, Huang KP, Joyce C, Mostaghimi A. The impact of alopecia areata on sexual quality of life. Int J Trichology. 2018;10(6):271–4.
pubmed: 30783334 pmcid: 6369646 doi: 10.4103/ijt.ijt_93_18
Liang X, Guo F, Cai X, et al. Association between vitiligo and sexual dysfunction: current evidence. Ann Med. 2023;55(1):946–53.
pubmed: 36892992 pmcid: 10795651 doi: 10.1080/07853890.2023.2182906
Sampogna F, Abeni D, Gieler U, et al. Impairment of sexual life in 3,485 dermatological outpatients from a multicentre study in 13 European countries. Acta Derm Venereol. 2017;97(4):478–82.
pubmed: 27819713 doi: 10.2340/00015555-2561
Leiblum SR, Pervin LA, Lief HI. Principles and practice of sex therapy. New York: Guilford; 1980.
Sabat R, Jemec GBE, Matusiak Ł, Kimball AB, Prens E, Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers. 2020;6(1):18.
pubmed: 32165620 doi: 10.1038/s41572-020-0149-1
Schultheis M, Staubach P, Grabbe S, et al. LAight® therapy is an effective treatment option to maintain long-term remission of Hurley I and II hidradenitis suppurativa: results from period B of RELIEVE, a multicenter randomized, controlled trial. Dermatology. 2022;238(6):1092–103.
pubmed: 35679831 doi: 10.1159/000524739
Schultheis M, Staubach P, Nikolakis G, et al. LAight® therapy significantly enhances treatment efficacy of 16 weeks of topical clindamycin solution in Hurley I and II hidradenitis suppurativa: results from Period A of RELIEVE, a multicenter randomized, controlled trial. Dermatology. 2022;238(3):476–86.
pubmed: 34535610 doi: 10.1159/000518540
Lenicura. The LAight Therapy: Lenicura; 2018. https://www.lenicura.com/ . Accessed 18 Mar 2024.
Zouboulis CC, Del Marmol V, Mrowietz U, Prens EP, Tzellos T, Jemec GB. Hidradenitis suppurativa/acne inversa: criteria for diagnosis, severity assessment, classification and disease evaluation. Dermatology. 2015;231(2):184–90.
pubmed: 26139027 doi: 10.1159/000431175
Schultheis M, Staubach-Renz P, Grabbe S, et al. Can hidradenitis suppurativa patients classify their lesions by means of a digital lesion identification scheme? J Dtsch Dermatol Ges. 2023;21(1):27–32.
pubmed: 36721938
Rosen R, Brown C, Heiman J, et al. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26(2):191–208.
pubmed: 10782451 doi: 10.1080/009262300278597
Berner M, Kriston L, Zahradnik HP, Härter M, Rohde A. Validity and reliability of the German Female Sexual Function Index (FSFI-d). Geburtshilfe Frauenheilkd. 2004;64:293–303.
doi: 10.1055/s-2004-815815
Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49(6):822–30.
pubmed: 9187685 doi: 10.1016/S0090-4295(97)00238-0
Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology. 1999;54(2):346–51.
pubmed: 10443736 doi: 10.1016/S0090-4295(99)00099-0
Berglund G, Nystedt M, Bolund C, Sjoden PO, Rutquist LE. Effect of endocrine treatment on sexuality in premenopausal breast cancer patients: a prospective randomized study. J Clin Oncol. 2001;19(11):2788–96.
pubmed: 11387349 doi: 10.1200/JCO.2001.19.11.2788
Krajewski PK, Strobel A, Schultheis M, et al. Hidradenitis suppurativa is associated with severe sexual impairment. Dermatology. 2024;240(2):205–15.
pubmed: 38190809 doi: 10.1159/000536128
Chernyshov PV, Zouboulis CC, Tomas-Aragones L, et al. Quality of life measurement in hidradenitis suppurativa: position statement of the European Academy of Dermatology and Venereology task forces on Quality of Life and Patient-Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa. J Eur Acad Dermatol Venereol. 2019;33(9):1633–43.
pubmed: 31037773 doi: 10.1111/jdv.15519
Finlay AY, Khan GK. Dermatology Life Quality Index (DLQI)–a simple practical measure for routine clinical use. Clin Exp Dermatol. 1994;19(3):210–6.
pubmed: 8033378 doi: 10.1111/j.1365-2230.1994.tb01167.x
Dimitrov D, Szepietowski JC. Instruments to assess stigmatization in dermatology. Postepy Hig Med Dosw (Online). 2017;71:901–5.
pubmed: 29151062 doi: 10.5604/01.3001.0010.5607
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.
pubmed: 6880820 doi: 10.1111/j.1600-0447.1983.tb09716.x
Rosenberg M, Schooler C, Schoenbach C. Self-esteem and adolescent problems: modeling reciprocal effects. Am Sociol Rev. 1989;54(6):1004–18.
doi: 10.2307/2095720
Krajewski PK, Matusiak Ł, von Stebut E, et al. Pain in hidradenitis suppurativa: a cross-sectional study of 1,795 patients. Acta Derm Venereol. 2021;101(1):adv00364.
pubmed: 33320274
Krajewski PK, Matusiak Ł, von Stebut E, et al. Quality-of-life impairment among patients with hidradenitis suppurativa: a cross-sectional study of 1795 patients. Life (Basel). 2021;11(1):34.
pubmed: 33429896
Rymaszewska JE, Krajewski PK, Szczęch J, Szepietowski JC. Depression and anxiety in hidradenitis suppurativa patients: a cross-sectional study among Polish patients. Postepy Dermatol Alergol. 2023;40(1):35–9.
pubmed: 36909902 doi: 10.5114/ada.2022.119080
Matusiak Ł. Profound consequences of hidradenitis suppurativa: a review. Br J Dermatol. 2020;183(6):e171–7.
pubmed: 29744872 doi: 10.1111/bjd.16603
Rymaszewska JE, Krajewski PK, Matusiak Ł, Maj J, Szepietowski JC. Satisfaction with life and coping strategies among patients with hidradenitis suppurativa: a cross-sectional study. J Clin Med. 2023;12(8):2755.
pubmed: 37109092 pmcid: 10144943 doi: 10.3390/jcm12082755
Rymaszewska JE, Karczewski M, Krajewski PK, Matusiak Ł, Maj J, Szepietowski JC. Patients’ expectations and satisfaction with the patient-doctor relationship in hidradenitis suppurativa. Healthcare (Basel). 2023;11(24):3139.
pubmed: 38132029 doi: 10.3390/healthcare11243139
Cuenca-Barrales C, Montero-Vilchez T, Krajewski PK, et al. Sexual dysfunction and quality of life in patients with hidradenitis suppurativa and their partners. Int J Environ Res Public Health. 2022;20(1):389.
pubmed: 36612709 pmcid: 9819626 doi: 10.3390/ijerph20010389
Włodarek K, Głowaczewska A, Matusiak Ł, Szepietowski JC. Psychosocial burden of hidradenitis suppurativa patients’ partners. J Eur Acad Dermatol Venereol. 2020;34(8):1822–7.
pubmed: 32003871 doi: 10.1111/jdv.16255
Cuenca-Barrales C, Montero-Vílchez T, Szepietowski JC, Matusiak L, Molina-Leyva A. Sexual impairment in patients with hidradenitis suppurativa: a systematic review. J Eur Acad Dermatol Venereol. 2021;35(2):345–52.
pubmed: 32531099 doi: 10.1111/jdv.16726
Kurek A, Peters EM, Chanwangpong A, Sabat R, Sterry W, Schneider-Burrus S. Profound disturbances of sexual health in patients with acne inversa. J Am Acad Dermatol. 2012;67(3):422–8, 8.e1.
pubmed: 22182915 doi: 10.1016/j.jaad.2011.10.024
Janse IC, Deckers IE, van der Maten AD, et al. Sexual health and quality of life are impaired in hidradenitis suppurativa: a multicentre cross-sectional study. Br J Dermatol. 2017;176(4):1042–7.
pubmed: 27534591 doi: 10.1111/bjd.14975
Alavi A, Farzanfar D, Rogalska T, Lowes MA, Chavoshi S. Quality of life and sexual health in patients with hidradenitis suppurativa. Int J Womens Dermatol. 2018;4(2):74–9.
pubmed: 30023423 pmcid: 6047191 doi: 10.1016/j.ijwd.2017.10.007
Zhu X, Wu Y, Jia J, Zhao X, Zhao X. Impact of endometriosis on female sexual function: an updated systematic review and meta-analysis. Sex Med. 2023;11(2):qfad026.
pubmed: 37256217 pmcid: 10226816 doi: 10.1093/sexmed/qfad026
Kurizky PS, Martins GA, Carneiro JN, Gomes CM, Mota L. Evaluation of the occurrence of sexual dysfunction and general quality of life in female patients with psoriasis. An Bras Dermatol. 2018;93(6):801–6.
pubmed: 30484522 pmcid: 6256218 doi: 10.1590/abd1806-4841.20183071
Ureña-Paniego C, Montero-Vílchez T, Sanabria-de-la-Torre R, Soto-Moreno A, Molina-Leyva A, Arias-Santiago S. Improvement of sexual function and sleep quality in patients with atopic dermatitis treated with dupilumab: a single-centre prospective observational study. Int J Environ Res Public Health. 2023;20(3):1918.
pubmed: 36767285 pmcid: 9914896 doi: 10.3390/ijerph20031918
Boquiren VM, Esplen MJ, Wong J, Toner B, Warner E, Malik N. Sexual functioning in breast cancer survivors experiencing body image disturbance. Psychooncology. 2016;25(1):66–76.
pubmed: 25916689 doi: 10.1002/pon.3819
Sousa Rodrigues Guedes T, Barbosa Otoni Gonçalves Guedes M, Mikael Lopes J, et al. Sexual dysfunction in women with breast cancer of Northeast Brazil: a retrospective longitudinal study. Sci Rep. 2023;13(1):20441.
pubmed: 37993511 pmcid: 10665323 doi: 10.1038/s41598-023-47684-7
Morrel B, van der Avoort IAM, Ewing-Graham PC, et al. Long-term consequences of juvenile vulvar lichen sclerosus: a cohort study of adults with a histologically confirmed diagnosis in childhood or adolescence. Acta Obstet Gynecol Scand. 2023;102(11):1469–78.
pubmed: 37632250 pmcid: 10577632 doi: 10.1111/aogs.14668
Yıldız Ş, Cengiz H, Kaya C, et al. Evaluation of genital self-image and sexual dysfunction in women with vulvar lichen planus or lichen sclerosus. J Psychosom Obstet Gynaecol. 2022;43(2):99–106.
pubmed: 33297796 doi: 10.1080/0167482X.2020.1857359
Ortmann O, Beckermann MJ, Inwald EC, Strowitzki T, Windler E, Tempfer C. Peri- and postmenopause-diagnosis and interventions interdisciplinary S3 guideline of the Association of the Scientific Medical Societies in Germany (AWMF 015/062): short version. Arch Gynecol Obstet. 2020;302(3):763–77.
pubmed: 32661753 pmcid: 7447675 doi: 10.1007/s00404-020-05682-4
Ferrini MG, Gonzalez-Cadavid NF, Rajfer J. Aging related erectile dysfunction-potential mechanism to halt or delay its onset. Transl Androl Urol. 2017;6(1):20–7.
pubmed: 28217447 pmcid: 5313305 doi: 10.21037/tau.2016.11.18
Çayan S, Kendirci M, Yaman Ö, et al. Prevalence of erectile dysfunction in men over 40 years of age in Turkey: results from the Turkish Society of Andrology Male Sexual Health Study Group. Turk J Urol. 2017;43(2):122–9.
pubmed: 28717533 pmcid: 5503428 doi: 10.5152/tud.2017.24886
Zang G, Sun X, Sun Y, et al. Chronic liver diseases and erectile dysfunction. Front Public Health. 2022;10:1092353.
pubmed: 36684968 doi: 10.3389/fpubh.2022.1092353
Costa MR, Ponciano VC, Costa TR, Gomes CP, de Oliveira EC. Stage effect of chronic kidney disease in erectile function. Int Braz J Urol. 2018;44(1):132–40.
pubmed: 29064656 pmcid: 5815543 doi: 10.1590/s1677-5538.ibju.2017.0228
Romano L, Pellegrino R, Sciorio C, et al. Erectile and sexual dysfunction in male and female patients with celiac disease: a cross-sectional observational study. Andrology. 2022;10(5):910–8.
pubmed: 35419983 pmcid: 9324123 doi: 10.1111/andr.13186
Kouidrat Y, Pizzol D, Cosco T, et al. High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies. Diabet Med. 2017;34(9):1185–92.
pubmed: 28722225 doi: 10.1111/dme.13403
Keenan HA. Do erectile dysfunction and cardiovascular disease have the same mechanism? Eur Urol. 2014;65(5):979–80.
pubmed: 24287318 doi: 10.1016/j.eururo.2013.11.013
Krajewski PK, Matusiak Ł, Szepietowski JC. Adipokines as an important link between hidradenitis suppurativa and obesity: a narrative review. Br J Dermatol. 2023;188(3):320–7.
pubmed: 36641766 doi: 10.1093/bjd/ljac107
May JL, Bobele M. Sexual dysfunction and the unemployed male professional. J Sex Marital Ther. 1988;14(4):253–62.
pubmed: 3225862 doi: 10.1080/00926238808403807

Auteurs

Piotr K Krajewski (PK)

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego 1, 50-368, Wroclaw, Poland.

Alexandra Strobel (A)

Faculty of Medicine, Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin Luther University Halle-Wittenberg, Saale, Halle, Germany.
Faculty of Medicine, Profile Centre of Health Sciences Halle, Martin Luther University Halle-Wittenberg, Saale, Halle, Germany.

Michael Schultheis (M)

Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany.

Petra Staubach (P)

Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany.

Stephan Grabbe (S)

Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany.

Katharina Hennig (K)

Department of Dermatology, University Medical Center, Johannes Gutenberg, University, Mainz, Germany.

Lukasz Matusiak (L)

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego 1, 50-368, Wroclaw, Poland.

Esther von Stebut (E)

Department of Dermatology, Faculty of Medicine, University of Cologne, Cologne, Germany.

Simone Garcovich (S)

Dermatology Outpatient Office Dr. Simone Garcovich, Rome, Italy.

Hans Bayer (H)

Dermatology Outpatient Office Hautmedizin Bad Soden, Bad Soden, Germany.

Marcus Heise (M)

Faculty of Medicine, Profile Centre of Health Sciences Halle, Martin Luther University Halle-Wittenberg, Saale, Halle, Germany.
Faculty of Medicine, Institute for Health- and Nursing Science, Martin-Luther-University Halle-Wittenberg, Saale, Halle, Germany.
Faculty of Medicine, Institute of General Practice and Family Medicine, Martin Luther University Halle-Wittenberg, Saale, Halle, Germany.

Uwe Kirschner (U)

Dermatology Outpatient Office Dr. Uwe Kirschner, Mainz, Germany.

Georgios Nikolakis (G)

Departments of Dermatology, Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg, Dessau, Germany.

Jacek C Szepietowski (JC)

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego 1, 50-368, Wroclaw, Poland. jacek.szepietowski@umw.edu.pl.
ORCID: 0000-0003-0766-6342

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