Mental health conditions and COVID-19 vaccine outcomes: A scoping review.

Research shows that people with a history of mental health conditions were at increased risk of COVID-19 infection, hospitalisation, and mortality. However, the relationship between mental health conditions and COVID-19 vaccine outcomes such as vaccine intention, uptake and vaccine breakthrough is not yet well-understood. We conducted a systematic search on the topics of COVID-19 vaccine intentions, vaccine uptake, and vaccine breakthrough, in relation to mental health conditions (e.g., depression, schizophrenia), in four databases: PubMed, MEDLINE, SCOPUS, and PsychINFO, and the publication lists of Clinical Practice Research Datalink (CPRD), The Health Improvement Network (THIN), OpenSAFELY, and QResearch. Inclusion criteria focussed on studies reporting any of the aforementioned COVID-19 vaccine outcomes among people with mental health conditions. Of 251 publications initially identified, 32 met our inclusion criteria. Overall, the evidence is inconclusive regarding the levels of intention to accept COVID-19 vaccines among people with mental health conditions. People with mental health conditions were more likely to have lower uptake of COVID-19 vaccines, compared to people without. Common barriers to COVID-19 vaccine uptake included concerns about the safety, effectiveness, and side effects of the vaccines. Limited evidence also suggests that vaccine breakthrough may be a particular risk for those with substance use disorder. Evidence for the association between COVID-19 vaccine intentions and mental health conditions is mixed. Vaccine uptake might be lower in people with mental health conditions compared to people without, yielding interventions to encourage vaccine uptake in this population. Our understanding of COVID-19 vaccine breakthrough in this population also needs enhancing.

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Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ru Jia reports financial support was provided by NIHR Oxford Biomedical Research Centre. Ru Jia reports financial support was provided by National Institute for Health Research School for Primary Care Research. Carol Coupland reports financial support was provided by NIHR Nottingham Biomedical Research Centre. Carol Coupland reports financial support was provided by National Institute for Health Research School for Primary Care Research. Yana Vinogradova reports financial support was provided by National Institute for Health Research School for Primary Care Research. Nadeem Qureshi reports financial support was provided by National Institute for Health Research School for Primary Care Research. Kavita Vedhara reports financial support was provided by National Institute for Health Research School for Primary Care Research. Emma Turner reports financial support was provided by UK Research and Innovation. This manuscript reflects preliminary work relating to UK Longitudinal Linkage Collaboration (UK LLC) project LLC_0027 and UK LLC funding from the UKRI--funded Longitudinal Health and Wellbeing National Core Study led by University College London (Grant code MC_PC_20059). If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.