Prognostics of multiple malaria episodes and nutritional status in children aged 6 to 59 months from 2013 to 2017 in Dangassa, Koulikoro region, Mali.
Anemia
Malaria
Multiple episodes
Nutritional status
Underweight
Journal
Malaria journal
ISSN: 1475-2875
Titre abrégé: Malar J
Pays: England
ID NLM: 101139802
Informations de publication
Date de publication:
13 Jun 2024
13 Jun 2024
Historique:
received:
13
11
2023
accepted:
26
05
2024
medline:
14
6
2024
pubmed:
14
6
2024
entrez:
13
6
2024
Statut:
epublish
Résumé
In Africa, the relationship between childhood nutritional status and malaria remains complex and difficult to interpret. Understanding it is important in the improvement of malaria control strategies. This study aimed to assess the influence of nutritional status on the occurrence of multiple malaria episodes in children aged 6 to 59 months between 2013 and 2017 living in the village of Dangassa, Mali. A community-based longitudinal study was conducted using cross-sectional surveys (CSSs) at the beginning (June) and end (November) of the malaria transmission season associated with passive case detection (PCD) at the Dangassa Community Health Centre. Children with asymptomatic malaria infection during cross-sectional surveys were selected and their malaria episodes followed by PCD. Malaria indicators in person-months were estimated using an ordinal-logistic model repeated on subjects during follow-up periods. The incidence rate (IR) during the period of high transmission (June to October), for 1 episode and for 2 + episodes peaked in 2013 with 65 children (IR = 95.73 per 1000 person-months) and 24 cases (IR = 35.35 per 1000 person-months), respectively. As expected, the risk of multiple episodes occurring during the period of high transmission was 3.23 compared to the period of low transmission after adjusting for other model parameters (95% CI [2.45-4.26], p = 0.000). Children with anaemia were at high risk of having multiple episodes (OR = 1.6, 95% CI [1.12-2.30], p = 0.011). However, the risk of having 2 + episodes for anemic children was higher during the period of low transmission (RR = 1.67, 95% CI [1.15-2.42], p = 0.007) compared to the period of high transmission (RR = 1.58, 95% CI [1.09-2.29], p = 0.016). The trend indicated that anemic and underweight children were significantly associated with multiple malaria episodes during the period of low transmission (p < 0.001). Results show that multiple episodes of malaria are significantly related to the nutritional status (anaemia and underweight) of the child during the two transmission seasons and more pronounced during the dry season (period of low transmission). Further research including other malnutrition parameters will be needed to confirm these findings.
Sections du résumé
BACKGROUND
BACKGROUND
In Africa, the relationship between childhood nutritional status and malaria remains complex and difficult to interpret. Understanding it is important in the improvement of malaria control strategies. This study aimed to assess the influence of nutritional status on the occurrence of multiple malaria episodes in children aged 6 to 59 months between 2013 and 2017 living in the village of Dangassa, Mali.
METHODS
METHODS
A community-based longitudinal study was conducted using cross-sectional surveys (CSSs) at the beginning (June) and end (November) of the malaria transmission season associated with passive case detection (PCD) at the Dangassa Community Health Centre. Children with asymptomatic malaria infection during cross-sectional surveys were selected and their malaria episodes followed by PCD. Malaria indicators in person-months were estimated using an ordinal-logistic model repeated on subjects during follow-up periods.
RESULTS
RESULTS
The incidence rate (IR) during the period of high transmission (June to October), for 1 episode and for 2 + episodes peaked in 2013 with 65 children (IR = 95.73 per 1000 person-months) and 24 cases (IR = 35.35 per 1000 person-months), respectively. As expected, the risk of multiple episodes occurring during the period of high transmission was 3.23 compared to the period of low transmission after adjusting for other model parameters (95% CI [2.45-4.26], p = 0.000). Children with anaemia were at high risk of having multiple episodes (OR = 1.6, 95% CI [1.12-2.30], p = 0.011). However, the risk of having 2 + episodes for anemic children was higher during the period of low transmission (RR = 1.67, 95% CI [1.15-2.42], p = 0.007) compared to the period of high transmission (RR = 1.58, 95% CI [1.09-2.29], p = 0.016). The trend indicated that anemic and underweight children were significantly associated with multiple malaria episodes during the period of low transmission (p < 0.001).
CONCLUSION
CONCLUSIONS
Results show that multiple episodes of malaria are significantly related to the nutritional status (anaemia and underweight) of the child during the two transmission seasons and more pronounced during the dry season (period of low transmission). Further research including other malnutrition parameters will be needed to confirm these findings.
Identifiants
pubmed: 38872178
doi: 10.1186/s12936-024-04999-8
pii: 10.1186/s12936-024-04999-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
186Subventions
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : NIH HHS
ID : U19AI089696
Pays : United States
Organisme : Fogarty International Center of the National Institutes of Health
ID : D43TW008652
Organisme : Fogarty International Center of the National Institutes of Health
ID : D43TW008652
Organisme : Fogarty International Center of the National Institutes of Health
ID : D43TW008652
Organisme : Fogarty International Center of the National Institutes of Health
ID : D43TW008652
Informations de copyright
© 2024. The Author(s).
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