A multi-organ, feto-maternal interface organ-on-chip, models pregnancy pathology and is a useful preclinical extracellular vesicle drug trial platform.

EVs Fetal membrane Interleukin-10 Microphysiological systems Placenta preterm birth

Journal

Extracellular vesicle
ISSN: 2773-0417
Titre abrégé: Extracell Vesicle
Pays: United States
ID NLM: 9918487587406676

Informations de publication

Date de publication:
Jun 2024
Historique:
medline: 14 6 2024
pubmed: 14 6 2024
entrez: 14 6 2024
Statut: ppublish

Résumé

Pregnant women and their fetuses are often excluded from clinical trials due to missing drug-related pre-clinical trial information at the human feto-maternal interface (FMi). The two interfaces-placenta/decidua and fetal membranes/decidua are gatekeepers of drug transport; however, testing their functions is impractical during pregnancy. Limitations of current

Identifiants

DOI: 10.1016/j.vesic.2024.100035 PMID: 38872854 PMC: PMC11175617
pubmed: 38872854
doi: 10.1016/j.vesic.2024.100035
pmc: PMC11175617
pii:
doi:

Types de publication

Journal Article

Langues

eng

Déclaration de conflit d'intérêts

Statements and Declarations: The authors declare no conflicts of interest.

Auteurs

Melody Safarzadeh (M)

Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

Lauren S Richardson (LS)

Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

Ananth Kumar Kammala (AK)

Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

Angela Mosebarger (A)

Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

Mohamed Bettayeb (M)

Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

Sungjin Kim (S)

Department of Biomedical Engineering and Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA.

Po Yi Lam (PY)

Department of Biomedical Engineering and Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA.

Enkhtuya Radnaa (E)

Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

Arum Han (A)

Department of Biomedical Engineering and Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA.

Ramkumar Menon (R)

Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.

Classifications MeSH