Structural basis of the monkeypox virus mRNA cap N7 methyltransferase complex.

Methyltransferases / chemistry Monkeypox virus / genetics Viral Proteins / chemistry Crystallography, X-Ray RNA Caps / metabolism Models, Molecular Humans Protein Conformation Protein Binding RNA, Messenger / genetics
Monkeypox virus SAXS mRNA cap N7 methyltransferase protein complex structure

Journal

Emerging microbes & infections
ISSN: 2222-1751
Titre abrégé: Emerg Microbes Infect
Pays: United States
ID NLM: 101594885

Informations de publication

Date de publication:
Dec 2024
Historique:
medline: 27 6 2024
pubmed: 14 6 2024
entrez: 14 6 2024
Statut: ppublish

Résumé

The global outbreak of Mpox, caused by the monkeypox virus (MPXV), has attracted international attention and become another major infectious disease event after COVID-19. The mRNA cap N7 methyltransferase (RNMT) of MPXV methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs and plays a vital role in evading host antiviral immunity. MPXV RNMT is composed of the large subunit E1 and the small subunit E12. How E1 and E12 of MPXV assembly remains unclear. Here, we report the crystal structures of E12, the MTase domain of E1 with E12 (E1

Identifiants

DOI: 10.1080/22221751.2024.2369193 PMID: 38873898
pubmed: 38873898
doi: 10.1080/22221751.2024.2369193
doi:

Substances chimiques

Methyltransferases EC 2.1.1.-
Viral Proteins 0
RNA Caps 0
RNA, Messenger 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2369193

Auteurs

Anke Chen (A)

State Key Laboratory of Genetic Engineering, School of Life Sciences and Huashan Hospital, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, Shanghai, People's Republic of China.

Ning Fang (N)

State Key Laboratory of Genetic Engineering, School of Life Sciences and Huashan Hospital, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, Shanghai, People's Republic of China.

Zhifei Zhang (Z)

State Key Laboratory of Genetic Engineering, School of Life Sciences and Huashan Hospital, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, Shanghai, People's Republic of China.

Yiqing Wen (Y)

State Key Laboratory of Genetic Engineering, School of Life Sciences and Huashan Hospital, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, Shanghai, People's Republic of China.

Yajie Shen (Y)

State Key Laboratory of Genetic Engineering, School of Life Sciences and Huashan Hospital, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, Shanghai, People's Republic of China.

Yanjie Zhang (Y)

Clinical Cancer Institute, Center for Translational Medicine, Naval Medical University, Shanghai, People's Republic of China.

Lu Zhang (L)

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.

Guoping Zhao (G)

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, People's Republic of China.
Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, People's Republic of China.

Jin Ding (J)

Clinical Cancer Institute, Center for Translational Medicine, Naval Medical University, Shanghai, People's Republic of China.

Jixi Li (J)

State Key Laboratory of Genetic Engineering, School of Life Sciences and Huashan Hospital, Shanghai Engineering Research Center of Industrial Microorganisms, Fudan University, Shanghai, People's Republic of China.
Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Structural basis of the monkeypox virus mRNA...
questionsmedicales.fr › Virus › Virus à ADN › Poxviridae › Chordopoxvirinae › Orthopoxvirus › Virus de la variole simienne › Structural basis of the monkeypox virus mRNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Structural basis of the monkeypox virus mRNA...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structural basis of the monkeypox virus mRNA...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides guanyliques › Coiffes des ARN › Structural basis of the monkeypox virus mRNA...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural basis of the monkeypox virus mRNA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural basis of the monkeypox virus mRNA...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structural basis of the monkeypox virus mRNA...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Structural basis of the monkeypox virus mRNA...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Structural basis of the monkeypox virus mRNA...