Low liver reserve is a risk factor for acute pancreatitis in patients with acute liver failure.
acute liver failure
acute pancreatitis
model for end‐stage liver disease
Journal
Hepatology research : the official journal of the Japan Society of Hepatology
ISSN: 1386-6346
Titre abrégé: Hepatol Res
Pays: Netherlands
ID NLM: 9711801
Informations de publication
Date de publication:
14 Jun 2024
14 Jun 2024
Historique:
revised:
17
05
2024
received:
22
03
2024
accepted:
25
05
2024
medline:
14
6
2024
pubmed:
14
6
2024
entrez:
14
6
2024
Statut:
aheadofprint
Résumé
Acute pancreatitis is a complication of acute liver failure (ALF). This study aimed to investigate the prevalence of and clinical features associated with acute pancreatitis in patients with ALF. We retrospectively analyzed a cohort of ALF patients without hepatic encephalopathy diagnosed during a period 2011-2018, and compared clinical features between patients with acute pancreatitis and those without. Acute pancreatitis was diagnosed according to the Acute Pancreatitis Clinical Practice Guidelines 2021. A multivariate analysis was carried out to identify factors associated with acute pancreatitis. There were 83 ALF patients without hepatic encephalopathy (34 men; 11 deaths; 6 liver transplants; median age, 63 years). Acute pancreatitis occurred in nine patients (10.8%). The median time duration from ALF to the onset of acute pancreatitis was 8 days. The survival rate was lower in patients with than those without acute pancreatitis (22% vs. 86%). The model for end-stage liver disease score (hazard ratio 1.10, 95% confidence interval 1.03-1.18) was found to be a significant factor associated with acute pancreatitis, whereas triglyceride, age, and sex were not. A high model for end-stage liver disease score may be a marker to stratify patients with ALF at a risk of acute pancreatitis.
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2024 Japan Society of Hepatology.
Références
Sugawara K, Nakayama N, Mochida S. Acute liver failure in Japan: definition, classification, and prediction of the outcome. J Gastroenterol. 2012;47(8):849–861. https://doi.org/10.1007/s00535‐012‐0624‐x
Akamatsu N, Sugawara Y, Kokudo N. Acute liver failure and liver transplantation. Intractable Rare Dis Res. 2013;2:77–87. https://doi.org/10.5582/irdr.2013.v2.3.77
O'Grady J. Timing and benefit of liver transplantation in acute liver failure. J Hepatol. 2014;60(3):663–670. https://doi.org/10.1016/j.jhep.2013.10.024
Ham JM, Fitzpatrick P. Acute pancreatitis in patients with acute hepatic failure. Am J Dig Dis. 1973;18(12):1079–1083. https://doi.org/10.1007/bf01076525
Parbhoo SP, Welch J, Sherlock S. Acute pancreatitis in patients with fulminant hepatic failure. Gut. 1973;14:428.
Kuo PC, Plotkin JS, Johnson LB. Acute pancreatitis and fulminant hepatic failure. J Am Coll Surg. 1998;187(5):522–528. https://doi.org/10.1016/s1072‐7515(98)00222‐1
Ede RJ, Moore KP, Marshall WJ, Williams R. Frequency of pancreatitis in fulminant hepatic failure using isoenzyme markers. Gut. 1988;29(6):778–781. https://doi.org/10.1136/gut.29.6.778
Cote GA, Gottstein JH, Daud A, Blei AT, Acute Liver Failure Study G. The role of etiology in the hyperamylasemia of acute liver failure. Am J Gastroenterol. 2009;104(3):592–597. https://doi.org/10.14309/00000434‐200903000‐00017
Kakisaka K, Suzuki Y, Takahashi F, Takikawa Y. Referral system has a diminished difference in the risk for hepatic encephalopathy development among each etiology in patients with acute liver injury. Hepatol Res. 2022;52(4):401–410. https://doi.org/10.1111/hepr.13744
Working Group IAPAPAAPG. IAP/APA evidence‐based guidelines for the management of acute pancreatitis. Pancreatology. 2013;13:e1–e15.
Said A, Williams J, Holden J, Remington P, Gangnon R, Musat A, et al. Model for end stage liver disease score predicts mortality across a broad spectrum of liver disease. J Hepatol. 2004;40(6):897–903. https://doi.org/10.1016/s0168‐8278(04)00064‐9
Tung YC, Hsiao FC, Lin CP, Ho CT, Hsu TJ, Chiang HY, et al. High triglyceride variability increases the risk of first attack of acute pancreatitis. Am J Gastroenterol. 2023;118(6):1080–1090. https://doi.org/10.14309/ajg.0000000000002198
de Pretis N, Amodio A, Frulloni L. Hypertriglyceridemic pancreatitis: epidemiology, pathophysiology and clinical management. United European Gastroenterol J. 2018;6(5):649–655. https://doi.org/10.1177/2050640618755002
Hadzic N, Height S, Ball S, Rela M, Heaton ND, Veys P, et al. Evolution in the management of acute liver failure‐associated aplastic anaemia in children: a single centre experience. J Hepatol. 2008;48(1):68–73. https://doi.org/10.1016/j.jhep.2007.08.017
Elvers FL, Stamouli M, Adelmeijer J, Jeyanesan D, Bernal W, Maas C, et al. In vivo generation of thrombin in patients with liver disease without apparent evidence of activation of the intrinsic or extrinsic pathway of coagulation. J Thromb Haemostasis. 2023;21(8):2078–2088. https://doi.org/10.1016/j.jtha.2023.03.017
de Oliveira LC, Rezende PB, Ferreira AL, de Freitas AA, Fleury Guedes CA, Pinheiro Costa WO. Concurrent acute hepatitis and pancreatitis associated with hepatitis B virus: case report. Pancreas. 1998;16(4):559–561. https://doi.org/10.1097/00006676‐199805000‐00019
Haffar S, Bazerbachi F, Prokop L, Watt KD, Murad MH, Chari ST. Frequency and prognosis of acute pancreatitis associated with fulminant or non‐fulminant acute hepatitis A: a systematic review. Pancreatology. 2017;17(2):166–175. https://doi.org/10.1016/j.pan.2017.02.008
Bazerbachi F, Haffar S, Garg SK, Lake JR. Extra‐hepatic manifestations associated with hepatitis E virus infection: a comprehensive review of the literature. Gastroenterol Rep (Oxf). 2016;4:1–15.
Bernal MV, Campillo Arregui A, Sostres Homedes C, Garcia Gil A, Simon Marco MA, Serrano Aullo MT. Acute necrotizing pancreatitis and severe hepatic failure: description of three cases. Transplant Proc. 2008;40(9):3117–3120. https://doi.org/10.1016/j.transproceed.2008.09.019
Geokas MC, Olsen H, Swanson V, Rinderknecht H. The association of viral hepatitis and acute pancreatitis. CA Med. 1972;117:1–7.
Sadr‐Azodi O, Mattsson F, Bexlius TS, Lindblad M, Lagergren J, Ljung R. Association of oral glucocorticoid use with an increased risk of acute pancreatitis: a population‐based nested case‐control study. JAMA Intern Med. 2013;173(6):444–449. https://doi.org/10.1001/jamainternmed.2013.2737
Prinz RA, Aranha GV. The association of primary hyperparathyroidism and pancreatitis. Am Surg. 1985;51:325–329.
Samokhvalov AV, Rehm J, Roerecke M. Alcohol consumption as a risk factor for acute and chronic pancreatitis: a systematic review and a series of meta‐analyses. EBioMedicine. 2015;2(12):1996–2002. https://doi.org/10.1016/j.ebiom.2015.11.023
Badalov N, Baradarian R, Iswara K, Li J, Steinberg W, Tenner S. Drug‐induced acute pancreatitis: an evidence‐based review. Clin Gastroenterol Hepatol. 2007;5(6):648–661. quiz 4. https://doi.org/10.1016/j.cgh.2006.11.023
Goya T, Kurokawa M, Hioki T, Aoyagi T, Takahashi M, Imoto K, et al. Elevated pancreatic enzymes associated with acute liver injury were mediated by tumor necrosis factor‐alpha signaling. Hepat Mon. 2022;22(1):e128106. https://doi.org/10.5812/hepatmon‐128106
Kakisaka K, Kataoka K, Suzuki Y, Kuroda H, Takikawa Y. Appropriate timing to start and optimal response evaluation of high‐dose corticosteroid therapy for patients with acute liver failure. J Gastroenterol. 2017;52(8):977–985. https://doi.org/10.1007/s00535‐017‐1306‐5
Kakisaka K, Suzuki Y, Abe H, Watanabe T, Yusa K, Sato H, et al. Early identification using the referral system prolonged the time to onset for hepatic encephalopathy after diagnosing severe acute liver injury. Sci Rep. 2020;10(1):17280. https://doi.org/10.1038/s41598‐020‐74466‐2
Kakisaka K, Suzuki Y, Jinnouchi Y, Kanazawa J, Sasaki T, Yonezawa T, et al. Unfavorable prognosis of patients with acute liver injury due to drug‐induced liver injury and acute exacerbation of hepatitis B virus infection. Hepatol Res. 2019;49(11):1286–1293. https://doi.org/10.1111/hepr.13397