Recent advances in hepatitis E virus research and the Japanese clinical practice guidelines for hepatitis E virus infection.
Japan Agency for Medical Research and Development
chronic infection
current and future research
guideline
hepatitis E virus
Journal
Hepatology research : the official journal of the Japan Society of Hepatology
ISSN: 1386-6346
Titre abrégé: Hepatol Res
Pays: Netherlands
ID NLM: 9711801
Informations de publication
Date de publication:
14 Jun 2024
14 Jun 2024
Historique:
revised:
22
04
2024
received:
25
03
2024
accepted:
09
05
2024
medline:
14
6
2024
pubmed:
14
6
2024
entrez:
14
6
2024
Statut:
aheadofprint
Résumé
Acute hepatitis E was considered rare until reports emerged affirming the existence of hepatitis E virus (HEV) genotypes 3 and 4 infections in Japan in the early 2000s. Extensive studies by Japanese researchers have highlighted the pivotal role of pigs and wild animals, such as wild boars and deer, as reservoirs for HEV, linking them to zoonotic infections in Japan. Currently, when hepatitis occurs subsequent to the consumption of undercooked or grilled pork, wild boar meat, or offal (including pig liver and intestines), HEV infection should be considered. Following the approval of anti-HEV immunoglobulin A antibody as a diagnostic tool for hepatitis E by Japan's Health Insurance System in 2011, the annual number of diagnosed cases of HEV infection has surged. Notably, the occurrence of post-transfusion hepatitis E promoted nationwide screening of blood products for HEV using nucleic acid amplification tests since 2020. Furthermore, chronic hepatitis E has been observed in immunosuppressed individuals. Considering the significance of hepatitis E, heightened preventive measures are essential. The Japan Agency for Medical Research and Development Hepatitis A and E viruses (HAV and HEV) Study Group, which includes special virologists and hepatologists, held a virtual meeting on February 17, 2024. Discussions encompassed pathogenesis, transmission routes, diagnosis, complications, severity factors, and ongoing and prospective vaccination or treatments for hepatitis E. Rigorous assessment of referenced studies culminated in the formulation of recommendations, which are detailed within this review. This comprehensive review presents recent advancements in HEV research and Japanese clinical practice guidelines for HEV infection.
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The Japan Agency for Medical Research and Development
ID : JP23fk0210132
Organisme : Japan Society for the Promotion of Science
ID : JP23K15055
Investigateurs
Mai Totsuka
(M)
Masayuki Honda
(M)
Shuhei Arima
(S)
Ryota Masuzaki
(R)
Naoki Matsumoto
(N)
Masahiro Ogawa
(M)
Hayato Abe
(H)
Masato Nakamura
(M)
Shuang Wu
(S)
Naoya Kato
(N)
Takeshi Yokoo
(T)
Kazunao Hayashi
(K)
Hiroteru Kamimura
(H)
Shuji Terai
(S)
Jong-Hon Kang
(JH)
Tominari Kobayashi
(T)
Norio Isoda
(N)
Shunji Watanabe
(S)
Hitoshi Mizuo
(H)
Junichi Koyama
(J)
Hitoshi Takagi
(H)
Yuichi Yamazaki
(Y)
Yukihiro Sato
(Y)
Hiroshi Okano
(H)
Tatsunori Nakano
(T)
Manri Kawakami
(M)
Akio Miyasaka
(A)
Tomohiko Koibuchi
(T)
Ryuichi Sugiyama
(R)
Mami Matsuda
(M)
Asuka Hirai-Yuki
(A)
Informations de copyright
© 2024 Japan Society of Hepatology.
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