Neurobehavioral Characterization of Perinatal Oxycodone-Exposed Offspring in Early Adolescence.
Anxiety
Anxiety-like
Inflammation
Oxycodone
Perinatal
Sex-differences
Socialization
Journal
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
ISSN: 1557-1904
Titre abrégé: J Neuroimmune Pharmacol
Pays: United States
ID NLM: 101256586
Informations de publication
Date de publication:
14 Jun 2024
14 Jun 2024
Historique:
received:
05
01
2024
accepted:
25
05
2024
medline:
14
6
2024
pubmed:
14
6
2024
entrez:
14
6
2024
Statut:
epublish
Résumé
The opioid epidemic has received considerable attention, but the impact on perinatal opioid-exposed (POE) offspring remains underexplored. This study addresses the emerging public health challenge of understanding and treating POE children. We examined two scenarios using preclinical models: offspring exposed to oxycodone (OXY) in utero (IUO) and acute postnatal OXY (PNO). We hypothesized exposure to OXY during pregnancy primes offspring for neurodevelopmental deficits and severity of deficits is dependent on timing of exposure. Notable findings include reduced head size and brain weight in offspring. Molecular analyses revealed significantly lower levels of inflammasome-specific genes in the prefrontal cortex (PFC). Gene Set Enrichment Analysis (GSEA) and Ingenuity Pathway Analysis (IPA) highlighted the enrichment of genes associated with mitochondrial and synapse dysfunction in POE offspring. Western blot analysis validated IPA predictions of mitochondrial dysfunction in PFC-derived synaptosomes. Behavioral studies identified significant social deficits in POE offspring. This study presents the first comparative analysis of acute PNO- and IUO-offspring during early adolescence finding acute PNO-offspring have considerably greater deficits. The striking difference in deficit severity in acute PNO-offspring suggests that exposure to opioids in late pregnancy pose the greatest risk for offspring well-being.
Identifiants
pubmed: 38874861
doi: 10.1007/s11481-024-10129-7
pii: 10.1007/s11481-024-10129-7
doi:
Substances chimiques
Oxycodone
CD35PMG570
Analgesics, Opioid
0
Types de publication
Journal Article
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
29Subventions
Organisme : NIDA NIH HHS
ID : DA046852-4S1
Pays : United States
Organisme : NIDA NIH HHS
ID : DA046852
Pays : United States
Organisme : NIDA NIH HHS
ID : DA046852-4S1
Pays : United States
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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